Flopropione, a cysteine-conjugate-β-lyase 1 inhibitor, for prevention of cisplatin-induced nephrotoxicity: protocol for a randomized, open-label, proof-of-concept phase I/IIa trial [0.03%]
用于预防顺铂引起的肾毒性的Flopropione（半胱氨酸缀合-β-裂解酶1抑制剂）：I/IIa期概念验证型随机开放标记试验的方案
Takenao Koseki,Masashi Kondo,Hidetsugu Fujigaki et al.
Takenao Koseki et al.
Background: Cisplatin-induced nephrotoxicity (CIN) is a major dose-limiting adverse event that can lead to both acute and chronic kidney injury. The formation of thiol-cisplatin conjugates within renal tubular cells has b...
Process Evaluation of a Structured Method for Systematic and Integrated Occupational Safety and Health and Patient Safety Management Systems (SIOHPS): Protocol for a Convergent Parallel Mixed Methods Study [0.03%]
结构化方法的过程评价促进系统性和综合性的职业健康与安全和患者安全管理系统（SIOHPS）：收敛并行混合研究法的方案
Camilla Göras,Ann-Sofie Ersson,Therese Hellman et al.
Camilla Göras et al.
Background: Health care systems are increasingly challenged by demographic shifts, rising chronic illnesses, human resource constraints, and growing efficiency demands. Improving both occupational safety and health (OSH) ...
Effect of Helpers Stay Quit Online Training on Preventing Smoking Relapse and Personal Networks: Protocol for a Pragmatic Randomized Controlled Trial and Embedded Mixed Methods Personal Network Study [0.03%]
戒烟者防复吸和社交圈研究：实用随机对照试验及嵌入式混合方法个人社交圈研究方案
Myra Muramoto,Allison Hopkins,Christopher McCarty et al.
Myra Muramoto et al.
Background: Despite major gains in smoking cessation treatment, over half of those who recently quit will relapse within one year. Two systematic reviews of relapse prevention studies reached differing conclusions on the ...
Effectiveness and Safety of Kangjia Decoction Granules for the Treatment of Hashimoto Thyroiditis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial [0.03%]
甲状腺激素汤颗粒治疗桥本病有效性和安全性的临床试验方案：随机、双盲、安慰剂对照、多中心临床试验
Duanchun Zhang,Dan Zhang,Xiaoxiao Qu et al.
Duanchun Zhang et al.
Background: Hashimoto thyroiditis (HT) is a chronic inflammation of the thyroid gland mediated by autoimmune disorders, often leading to hypothyroidism and a significant reduction in a patient's quality of life. At the ti...
Acceptance and Commitment to Empowerment Intervention to Reduce HIV Stigma and Promote Community Resilience: Protocol for an Implementation Study [0.03%]
增强能力干预措施的接受和承诺以减少艾滋病污名并促进社区韧性：实施研究方案
Josephine Pui-Hing Wong,Alan Tai-Wai Li,Carla T Hilario et al.
Josephine Pui-Hing Wong et al.
Background: Racialized immigrants are disproportionately impacted by HIV in Canada. In 2022, 69.5% of first-time HIV cases, where race and/or ethnicity was reported, were among racialized individuals: Indigenous (22.6%), ...
Effectiveness of an Educational and Counseling Program (the Green Mother Project Phase 2) to Enhance Breastfeeding and Improve Mothers' Diets From an Environmental Perspective: Protocol for a Cluster Randomized Controlled Trial [0.03%]
一项促进母乳喂养和从环境角度改善母亲饮食的教育咨询项目（绿地妈妈项目第二阶段）有效性的集群随机对照试验方案
Rosa Maria Cabedo-Ferreiro,Liudmila Liutsko,Judit Cos-Busquets et al.
Rosa Maria Cabedo-Ferreiro et al.
Background: Exclusive breastfeeding is recommended as healthier and more sustainable than formula feeding. It produces less waste, requires fewer resources, and has a smaller environmental impact. Breastfeeding has some e...
Comparative Evaluation of Push-Out Bond Strength of Glass Fiber Posts and Carbon Fiber Posts in Root Canals Treated With Calcium Hydroxide-Based, Resin-Based, and Bioceramic-Based Root Canal Sealers: Protocol for an In Vitro Study [0.03%]
玻璃纤维桩和碳纤维桩在氢氧化钙基、树脂基和生物陶瓷基根管密封剂中经治疗的根管中的推入结合强度的比较评估：一项体外研究方案
Vinus Shivlani,Manoj Chandak,Sanika Damle
Vinus Shivlani
Background: For root canal procedures to be successful, adequate bond strength between endodontic sealer and post material is necessary. For postendodontic restorations, glass fiber posts and carbon fiber posts are freque...
Comparative Study
JMIR research protocols. 2026 Jan 26:15:e76621. DOI:10.2196/76621 2026
Combining Noninvasive Brain Stimulation and Physiotherapy to Improve the Management of Chronic Low Back Pain in Veterans: Protocol for a Multi-Arm Randomized Controlled Trial [0.03%]
结合非侵入性脑刺激和物理治疗改善退伍军人慢性下背痛管理的方案：多臂随机对照试验方案
Frederique Dupuis,Yannick Tousignant-Laflamme,Pascale Marier Deschênes et al.
Frederique Dupuis et al.
Background: Low back pain (LBP) is the most common chronic pain condition in veterans, but the effectiveness of standard management approaches is modest. Addressing the psychological risk factors of chronic pain that are ...
Determinants Associated With Pesticide Exposure in Patients With Head and Neck Cancer: Protocol for a Systematic Review [0.03%]
头颈癌患者农药暴露的相关因素：系统回顾方案
Gustavo Adolfo Sánchez-Ramírez,Manuel López Cabanillas Lomelí,Blanca Edelia González-Martínez et al.
Gustavo Adolfo Sánchez-Ramírez et al.
Background: Currently, head and neck cancer (HNC) associated with pesticide exposure represents a global public health concern. However, there is no consensus regarding the specific determinants involved in this associati...
Developing the Link-me+EMPHN Mental Health Model of Care to Improve General Practitioner Capacity for Mental Health Care in Australian Primary Care: Protocol for a Mixed Methods Formative Study [0.03%]
建立Link-me + EMPHN心理健康护理模式以提高澳大利亚全科医生的心理健康照护能力：混合方法形成性研究方案
Amy Coe,Jane London,Anne-Marie Martin et al.
Amy Coe et al.
Background: The rising prevalence of mental health conditions continues to place significant pressure on general practitioners (GPs) and general practice. Despite their critical role in managing mental health conditions, ...