Flopropione, a cysteine-conjugate-β-lyase 1 inhibitor, for prevention of cisplatin-induced nephrotoxicity: protocol for a randomized, open-label, proof-of-concept phase I/IIa trial
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Background: Cisplatin-induced nephrotoxicity (CIN) is a major dose-limiting adverse event that can lead to both acute and chronic kidney injury. The formation of thiol-cisplatin conjugates within renal tubular cells has been impl... ...
