Acquired Aplastic Anemia Therapies: Immunosuppressive Therapy Versus Alternative Donor Hematopoietic Cell Transplantation [0.03%]
获得性再生障碍性贫血的治疗：免疫抑制疗法与替代供者造血细胞移植的区别
Baldeep Wirk
Baldeep Wirk
Immunosuppressive therapy for acquired severe aplastic anemia improves pancytopenia but has a significant risk of relapse (40%) and clonal evolution to myeloid neoplasms (15%), especially in patients older than 40. Yet, current guidelines f...
Sickle Cell Screening in Adults: A Current Review of Point-of-Care Testing [0.03%]
成人镰状细胞筛查：即时检验的最新综述
Sebastian R Mendez-Marti,Chad Zik,Sheinei Alan et al.
Sebastian R Mendez-Marti et al.
In adults, the sickle cell solubility test (SCST) is the most common screening test to determine the presence of hemoglobin S (HbS) within a blood sample. The assay is inexpensive, rapid, highly sensitive and specific. However, the SCST can...
Frameshift Mutations in Leukemia-Associated Genes Correlate With Superior Outcomes in Patients Undergoing Allogeneic Stem Cell Transplant for De Novo Acute Myeloid Leukemia [0.03%]
急性髓系白血病患者进行同种异体干细胞移植后，与较佳预后相关的 leukemia-associated 基因移位突变研究
Emma Cammann,Sindha Madhav,Lloyd Hutchinson et al.
Emma Cammann et al.
Background: Allogeneic stem cell transplant (allo-SCT) is a mainstay of treatment for acute myeloid leukemia (AML). Its success depends largely on response of donor T lymphocytes against leukemia cells, known as graft-vs-...
Venous Thromboembolism Following COVID-19 Vaccination in Patients With Hereditary Protein S Deficiency [0.03%]
遗传性蛋白S缺乏患者接种新冠疫苗后发生静脉血栓栓塞事件
Molly Rayner,Kelsey Brose
Molly Rayner
Hereditary protein S (PS) deficiency is a rare condition associated with increased risk of venous thromboembolism (VTE). In 2020, the coronavirus disease 2019 (COVID-19) pandemic prompted development of vaccinations to protect against the v...
Case Reports
Journal of hematology. 2024 Jun;13(3):125-127. DOI:10.14740/jh1278 2024
A Hemoglobinopathy That Produces an Array of Different Hemoglobin A1c Values [0.03%]
一种可产生多种不同糖化血红蛋白A1c值的异常血红蛋白病
Maximo J Marin,Bremansu Osa-Andrews,Patrick A Maher et al.
Maximo J Marin et al.
Hemoglobin A1c (HbA1c) refers to non-enzymatically glycated hemoglobin and reflects the patient's glycemic status over approximately 3 months. An elevated HbA1c over 6.5% National Glycohemoglobin Standardization Program (NGSP) (48 mmol/mol ...
Case Reports
Journal of hematology. 2024 Jun;13(3):99-103. DOI:10.14740/jh1268 2024
Non-Secretory Multiple Myeloma Associated With High-Risk Phenotype and Complex Cytogenetics Including t(8;22) [0.03%]
伴有高危表型和包括t(8;22)的复杂细胞遗传学的无分泌多发性骨髓瘤
Rahim A Jiwani,Joseph R Liput,Attah Abraham et al.
Rahim A Jiwani et al.
Multiple myeloma (MM) is a plasma cell dyscrasia which is typically characterized by identifiable paraprotein in the blood or urine. However, the minority of patients in whom paraprotein cannot be identified are designated non-secretory MM ...
Case Reports
Journal of hematology. 2024 Jun;13(3):94-98. DOI:10.14740/jh1248 2024
Recurrent Infection in a Young Female Patient Recently Diagnosed With Primary Evans Syndrome Without Neutropenia [0.03%]
一名近期确诊为原发Evans综合征(无中性粒细胞减少)的年轻女性患者反复感染
Jennie An,Preye Amaruntowa,Waleed Ahmed et al.
Jennie An et al.
Evans syndrome (ES) is a rare autoimmune condition of unknown etiology that occurs in a small subset of patients diagnosed, either sequentially or concomitantly, with immune thrombocytopenia (ITP) or warm autoimmune hemolytic anemia (AIHA)....
Case Reports
Journal of hematology. 2024 Jun;13(3):121-124. DOI:10.14740/jh1265 2024
Steady-State Versus Chemotherapy-Based Stem Cell Mobilization in Multiple Myeloma: A Single-Center Study to Analyze Efficacy and Safety [0.03%]
稳定状态与化疗基于的干细胞动员在多发性骨髓瘤中的疗效和安全性的单一中心研究
Nora Obajed Al-Ali,Laszlo Imre Pinczes,Katalin Farkas et al.
Nora Obajed Al-Ali et al.
Background: High-dose chemotherapy followed by autologous hematopoietic stem cell support is recommended in the treatment of eligible multiple myeloma (MM) patients. The aim of this study was to compare the efficacy and s...
Unraveling the Rare Entity of KIT D816V-Negative Systemic Mastocytosis [0.03%]
揭秘KIT D816V阴性全身性mastocytosis罕见病例
Ruah Alyamany,Chams Alkhalaf Albachir,Sarah Alsaleh et al.
Ruah Alyamany et al.
Systemic mastocytosis (SM) is a rare type of myeloproliferative neoplasm characterized by abnormal proliferation and infiltration of different tissue by clonal mast cells. The uncontrolled proliferation and activation of mast cells trigger ...
Case Reports
Journal of hematology. 2024 Jun;13(3):128-136. DOI:10.14740/jh1279 2024
A Unique Case of a Compound Heterozygosity of Hemoglobin Korle-Bu and Sickle Cell Trait in a Military Trainee [0.03%]
一名军事训练员同时患有科勒-布型血红蛋白和镰状细胞特质的罕见病例报告
Gartrell C Bowling,Niels A Ryden,Allen R Holmes et al.
Gartrell C Bowling et al.
Hemoglobin Korle-Bu (Hb KB) is a rare and likely under-reported hemoglobin (Hb) variant resulting from an unusual point mutation on the beta-globin chain. Hb KB is typically clinically silent, and there are limited reports of Hb KB heterozy...
Case Reports
Journal of hematology. 2024 Jun;13(3):116-120. DOI:10.14740/jh1257 2024