Evaluating Hemoglobin Thresholds for Blood Transfusions in Oncology Patients Admitted to the Intensive Care Unit [0.03%]
评估血液肿瘤患者入重症监护病房的输血阈值
Barath Prashanth Sivasubramanian,Abijha Boban,Andrew Strike et al.
Barath Prashanth Sivasubramanian et al.
Background: In the intensive care unit (ICU), up to 90% of patients develop anemia during their stay. However, evidence regarding transfusion practices in oncology patients requiring ICU-level care is limited. This study ...
Abnormal Eosinophils With Large, Distinctly Basophilic Granules (Harlequin Cells) on Peripheral Blood Smear: A Clue for Diagnosing Chronic Myeloid Leukemia [0.03%]
外周血涂片中带有大型深嗜碱性颗粒的异常嗜酸性粒细胞（马戏团细胞）：慢性髓系白血病诊断线索
Jennifer Cai,Changjun Yue,Sarah Tomassetti
Jennifer Cai
Background: Chronic myeloid leukemia (CML) often presents with hematologic findings that overlap with reactive leukocytosis and other myeloproliferative neoplasms (MPNs), creating diagnostic uncertainty that may delay tar...
Engraftment Outcome of CRISPR/Cas9-Edited Hematopoietic Stem Cells for Genetic Diseases: A Systematic Review and Meta-Analysis of Preclinical Evidence [0.03%]
基于CRISPR/Cas9编辑的造血干细胞植入效果的系统评价和荟萃分析：遗传病的临床前证据
Sudhanshu Yadav,Bandana Chakravarti,Baby Anjum et al.
Sudhanshu Yadav et al.
Background: CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9)-based gene editing represents a promising frontier for treating monogenic hematologic disorders. Several ...
Luspatercept: From Bench to Bedside and Beyond in the Management of Ineffective Erythropoiesis [0.03%]
Luspatercept：从实验室到临床，在无效红细胞生成管理中的应用及前景展望
Dhara Popat,Rajan Desai,Sheikh Abdullah et al.
Dhara Popat et al.
Luspatercept is a novel erythroid maturation agent that has emerged as a significant advancement in the management of ineffective erythropoiesis. By targeting the transforming growth factor-β superfamily signaling pathway, Luspatercept enh...
Post-Transplant Cyclophosphamide Allows Allogeneic Hematopoietic Stem-Cell Transplantation Across Donor Types for Nonmalignant Hematologic Diseases [0.03%]
移植后环磷酰胺允许非恶性血液系统疾病的各种供者类型异基因造血干细胞移植
Baldeep Wirk,Xiaoyan Deng
Baldeep Wirk
Background: The aim of the study was to compare post-transplant cyclophosphamide (PTCY)-based regimens with historical regimens using calcineurin inhibitor and methotrexate (CNI-MTX) for allogeneic hematopoietic stem-cell...
Identification and Pathogenicity Analysis of a Novel Fibrinogen Bβ Chain p.Gly293Val Variant Causing Hypofibrinogenemia [0.03%]
一种新型纤溶蛋白Bβ链p.Gly293Val变异导致低纤溶蛋白血症的鉴定及致病性分析
Xiao Li Cheng,Lin Zhu,Yi Juan Xin et al.
Xiao Li Cheng et al.
Background: Hypofibrinogenemia is a rare bleeding disorder characterized by excessive bleeding, impaired wound healing, and elevated perioperative risk. It most commonly results from pathogenic variants in the FGB gene. T...
Adriamycin, Vinblastine and Dacarbazine With Immunotherapy Achieves Complete Metabolic Response in a Patient With Classical Hodgkin Lymphoma and Dyskeratosis Congenita [0.03%]
达卡巴嗪联合免疫治疗在经典型霍奇金淋巴瘤和获得性 dickermann 综合征患者中取得完全代谢消失
Calum Slapnicar,Prateek Lala,Stephanie Lee et al.
Calum Slapnicar et al.
Dyskeratosis congenita (DC) is a rare inherited telomeropathy characterized by defective telomere maintenance and an elevated risk of hematologic malignancies. Classical Hodgkin lymphoma (cHL) is a rare malignancy described in patients with...
Case Reports
Journal of hematology. 2026 Mar 10;15(2):129-134. DOI:10.14740/jh2160 2026
Mean Corpuscular Volume in HFE p.C282Y/p.H63D Compound Heterozygotes With High Iron Phenotypes: Clinical and Laboratory Associations [0.03%]
HFE基因C282Y/H63D复合杂合子高铁表型的平均红细胞体积及其临床和实验室相关因素分析
James C Barton,J Clayborn Barton,Ronald T Acton
James C Barton
Background: The aim of this study was to define the relationships between mean corpuscular volume (MCV) and 12 clinical and laboratory variables in HFE p.C282Y (rs1800562)/p.H63D (rs1799945) compound heterozygotes. ...
A Rare Presentation of T-cell Prolymphocytic Leukemia With Abnormal Uterine Bleeding [0.03%]
以异常子宫出血为表现的T细胞-prolymphocytic白血病一例
Zeinab Nasser,Sarine Tahmazian,Moneb Bughrara et al.
Zeinab Nasser et al.
T-cell prolymphocytic leukemia (T-PLL) is a rare and clinically aggressive T-cell neoplasm, which is composed of lymphoid cells that are of post-thymic T-cell origin. This is a case of a 57-year-old female with no significant medical histor...
Case Reports
Journal of hematology. 2026 Jan 4;15(1):45-49. DOI:10.14740/jh2152 2026
Immune Response Associated Hepatotoxicity in Hemophilia Gene Therapy: Mechanisms, Management, and Challenges [0.03%]
血友病基因治疗相关的免疫反应性肝毒性：机制、管理和挑战
Chang Cheng Zheng
Chang Cheng Zheng
Adeno-associated virus (AAV)-based gene therapy offers the potential for long-term functional cure in patients with hemophilia A and B. However, immune responses triggered by the vector capsid or transgene product, leading to hepatotoxicity...