Utility of p53 Immunohistochemical Staining for Risk Stratification of Mantle Cell Lymphoma [0.03%]
p53免疫组化在套细胞淋巴瘤预后分层中的价值分析
Ibrahim Elsharawi,Sorin Selegean,Michael Carter
Ibrahim Elsharawi
Background: Inactivating TP53 mutations in mantle cell lymphoma (MCL) are associated with poor prognosis. While next-generation sequencing (NGS) is the gold standard for assessing TP53, p53 immunohistochemistry (IHC) is a...
The Influence of Circulating Exosomes Derived From Younger and Older Donors on Hypoxia-Inducible Factor 1 Alpha Gene Expression and P21 Protein in Cord Blood Hematopoietic Stem Cells [0.03%]
来自年轻和年老供者的循环外泌体对脐血造血干细胞中缺氧诱导因子1α基因表达及P21蛋白的影响
Zahra Rasti,Reza Afrisham,Elahe Bahrami Vahdat et al.
Zahra Rasti et al.
Background: Exosomes are a group of extracellular vesicles that are influential in intercellular signaling and can affect aging. Hypoxia-inducible factor 1α (HIF-1α) is the principal mediator in response to hypoxia and ...
Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma of Childhood Associated With t(1;22)(p22;q11.2) Mutation [0.03%]
与t(1;22)(p22;q11.2)易位有关的儿童EB病毒阳性T细胞淋巴瘤
Lane Lerner,Sushanth Sreenivasan,Chelsea Peterson et al.
Lane Lerner et al.
Systemic Epstein-Barr virus-positive (EBV+) T-cell lymphoma (TCL) of childhood is an uncommon TCL that occurs secondary to an acute or chronic EBV infection. The disorder is characterized by the monoclonal expansion of EBV+ T cells driven b...
Case Reports
Journal of hematology. 2024 Oct;13(5):229-237. DOI:10.14740/jh1284 2024
Successful Treatment of Idiopathic Multicentric Castleman Disease With Rash as the Initial Symptom Using a Rituximab-Based Regimen [0.03%]
以皮疹为首发症状的多中心型Castleman病成功采用利妥昔单抗为基础方案治疗病例报告
Li Zhu,Yi Liu,Fang Yu et al.
Li Zhu et al.
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by enlarged lymph nodes and systemic inflammation, often involving multiple organ dysfunction. However, cutaneous involvement in iMCD is r...
Case Reports
Journal of hematology. 2024 Oct;13(5):245-249. DOI:10.14740/jh1313 2024
Freedom From Bleeds With Low-Dose Emicizumab Prophylaxis in Inhibitor-Positive Hemophilia A [0.03%]
低剂量emicizumab预防性治疗在阳性抑制物甲型血友病患者中的应用可避免出血事件
Nita Radhakrishnan,Archit Pandharipande,Savitri Singh et al.
Nita Radhakrishnan et al.
Background: The real-world data on outcome of hemophilia A patients with inhibitors (HAI) is sparse, especially from developing countries. In a setting of inequitable healthcare opportunities for hemophilia patients, espe...
Siltuximab in Idiopathic Multicentric Castleman Disease: Real-World Experience [0.03%]
伊立替康治疗多中心型卡斯特利曼病的现实世界研究经验
Ciprian Jitaru,Argyris Symeonidis,Sorina Badelita et al.
Ciprian Jitaru et al.
Background: Castleman disease (CD) is a very rare, non-malignant lymphoproliferative disorder that can be classified as unicentric or multicentric (MCD). MCD is associated with systemic symptoms, including organ dysfuncti...
Breast Cancer With Release of Tumor Cells in Peripheral Blood Mimicking Acute Myeloid Leukemia [0.03%]
乳腺癌伴肿瘤细胞外周血溢出类似急性髓系白血病
Arianna Gatti,Bruno Brando,Irene Cuppari et al.
Arianna Gatti et al.
A 75-year-old woman with a history of lobular breast adenocarcinoma treated with mastectomy and radiotherapy in 2021 and on maintenance hormone therapy, presented with asthenia and tremors. Laboratory tests showed leucocytosis, anemia and l...
Case Reports
Journal of hematology. 2024 Aug;13(4):168-173. DOI:10.14740/jh1259 2024
Zoe McKinnell,Daniel Tuerff,Mustafa Hammudi et al.
Zoe McKinnell et al.
Background: Age is a strong prognostic factor in acute lymphocytic leukemia (ALL), with children doing better than adults with the same disease. One hypothesis for this age-based disparity is differences in treatment regi...
David Green
David Green
Deficiencies of factor VIII (FVIII)/von Willebrand factor (VWF) or factor IX (FIX) are underappreciated as potential reasons for heavy menstrual bleeding, recurrent nosebleeds, and easy bruising in girls and women. Bleeding is usually not a...
Is There a Correlation Between Immune Thrombocytopenia and Immunoglobulin G4-Related Disease? [0.03%]
免疫性血小板减少症与IgG4相关疾病的相关性研究
Dorela Lame,Michelangelo Pianelli,Erika Morsia et al.
Dorela Lame et al.
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition causing organ swelling and fibrosis. Rarely, it coexists with primary immune thrombocytopenia (ITP), characterized by low platelet count (< 100 × 106/L) without an...
Case Reports
Journal of hematology. 2024 Aug;13(4):174-177. DOI:10.14740/jh1260 2024