Iron-Induced Hypophosphatemia: A Review of Pathophysiology, Drug Safety, and Pharmacogenomic Perspectives [0.03%]
铁诱导的低磷血症：病理生理、药物安全和药理基因组学视角综述
Simone Pozzessere
Simone Pozzessere
Intravenous (IV) iron therapy is a cornerstone in the management of iron deficiency anemia, yet its administration is associated with significant side effects, most notably hypophosphatemia. This adverse event is not a class effect but is d...
Fever: Harmless Heat or a Deadly Inferno? Unmasking Hemophagocytic Lymphohistiocytosis and Beyond: A Rare Case of Mast Cell Sarcoma and Overview of HLH [0.03%]
发热：无害的热度还是致命的烈焰？——以一例巨噬细胞活化综合征伴嗜酸性肉芽肿和不明系统性肿瘤为视角揭露噬血细胞综合征及其他
Karan J Yagnik,Adelaine Espiritu,Malay Rathod et al.
Karan J Yagnik et al.
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal hyperinflammatory syndrome characterized by uncontrolled activation of the immune system, often secondary to infections, autoimmune diseases, or malignancies. While ma...
Case Reports
Journal of hematology. 2025 Oct 10;14(5):273-280. DOI:10.14740/jh2087 2025
Novel Agents and Immunotherapies for Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System: Innovating for Impact in a Disease With Unmet Needs [0.03%]
中枢神经系统原发性弥漫大B细胞淋巴瘤的新型药物和免疫疗法：创新改善一种未被满足需求疾病的结局
Tatyana Gavrilova
Tatyana Gavrilova
Primary diffuse large B-cell lymphoma of the central nervous system (CNS-DLBCL), the most prevalent subtype of primary CNS lymphoma (PCNSL), is a highly aggressive extranodal non-Hodgkin lymphoma (NHL) that arises in the brain, spinal cord,...
Osama Batayneh,Deevyashali Parekh,Margarita Vazquez Almonte et al.
Osama Batayneh et al.
Background: While molecular and cytogenetic testing may change prognosis and guide treatment intensity for patients with acute myeloid leukemia (AML), timing from diagnosis to treatment (TDT) on the other hand may impact ...
Fixed-Dose Four-Factor Prothrombin Complex Concentrate for Reversal of Anticoagulation: Evaluation of Efficacy, Safety, and Cost Savings [0.03%]
Amer Al Homssi,Ryan Lokkesmoe,Ryan Powers et al.
Amer Al Homssi et al.
Background: Four-factor prothrombin complex concentrate (4F-PCC) is used for warfarin reversal and off-label management of bleeding in patients taking direct oral anticoagulants (DOACs). Dosing strategies that optimize he...
Rowena Lee Ying Kwan,Ryan Mao Heng Lim,Jason Yongsheng Chan
Rowena Lee Ying Kwan
Background: Ocular adnexal marginal zone lymphoma (OAMZL) is the most common subtype of primary ocular lymphoma and has been rising in incidence in Asian populations. ...
Mast Cell Leukemia: Comprehensive Review of Literature With Current Insights and Updates on Management [0.03%]
Muralidhar Idamakanti,Ala Ebaid,Rani Indrani Bijjam et al.
Muralidhar Idamakanti et al.
Mast cell leukemia (MCL) is an exceedingly rare and aggressive variant of systemic mastocytosis (SM). MCL is classified as primary, occurring de novo without prior mast cell (MC) disorders or secondary, from a pre-existing SM, and acute agg...
B-Cell Lymphoma 2 Inhibition in Acute Lymphoblastic Leukemia: Mechanisms, Resistance, and Emerging Combinations With Venetoclax [0.03%]
急性淋巴细胞白血病中B细胞淋巴瘤2抑制：机制、耐药性及与维奈克拉联合用药的新进展
Amr Hanbali,Ahmed Kotb,Mostafa Saleh
Amr Hanbali
Recent studies show that the B-cell lymphoma 2 (BCL-2) inhibitor venetoclax is a promising therapeutic drug for acute lymphoblastic leukemia (ALL), especially in high-risk subtypes including early T-cell precursor (ETP)-ALL, Philadelphia ch...
Beyond the Blood Cell: The Emerging Role of Cell-Free DNA in Transfusion Medicine [0.03%]
超越血细胞：游离DNA在输血医学中作用初探
Jackson M Wahman,Rhoda X Hijazi,Elizabeth Duncan et al.
Jackson M Wahman et al.
Cell-free DNA (cfDNA) consists of fragmented nuclear and mitochondrial DNA circulating in the bloodstream, primarily originating from hematopoietic cells. While cfDNA analysis has transformed diagnostic medicine, its presence in transfused ...
Efficacy and Safety of Momelotinib in Myelofibrosis: A Systematic Review and Meta-Analysis With a Focus on Anemia Outcomes [0.03%]
妈妈洛替尼治疗骨髓纤维化疗效和安全性的系统评价和荟萃分析：聚焦贫血相关结局
Jowan Al-Nusair,Mo&#x;men Aldalal&#x;ah,Mohammad Alqudah et al.
Jowan Al-Nusair et al.
Background: Myelofibrosis (MF) can be primary (PMF) or secondary (SMF), with PMF driven by Janus kinases-signal transducer and activator of transcription proteins (JAK-STAT) pathway activation due to Janus kinase 2 (JAK2)...