Anti-Programmed Cell Death-1 Versus Anti-Programmed Death-Ligand 1 (PD-L1) in PD-L1-Negative Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis [0.03%]
程序性死亡受体1抑制剂与程序性死亡配体1抑制剂治疗程序性死亡配体1阴性晚期非小细胞肺癌的系统评价和 meta 分析
Laith Al-Showbaki,Malak Al-Kasasbeh,Karem Jbarah et al.
Laith Al-Showbaki et al.
Background: Immune checkpoint inhibitors (ICIs) which target programmed cell death-1 (PD-1) receptor or its ligand (PD-L1) are used extensively in non-small cell lung cancer (NSCLC). In this article, we compared the relat...
Adjuvant Therapy Benefits for Patients With Human Epidermal Growth Factor Receptor 2-Positive T1aN0M0 Breast Cancer: A Systematic Review and Meta-Analysis [0.03%]
人表皮生长因子受体2阳性T1aN0M0期乳腺癌患者的辅助治疗收益：系统评价和meta分析
Ezzeldin M Ibrahim,Ahmed A Refae,Ali M Bayer et al.
Ezzeldin M Ibrahim et al.
Background: While the prognosis for patients with human epidermal growth factor receptor 2 (HER2)-positive pT1a-bN0M0 breast cancer is generally favorable, the optimal approach to personalize adjuvant treatment for T1a tu...
Prognostic Significance of Post-Neoadjuvant Chemotherapy Carbohydrate Antigen 19-9 Levels in Patients With Resectable Pancreatic Cancer Treated With S-1 and Gemcitabine: A Retrospective Cohort Study [0.03%]
卡培他滨和吉西他滨新辅助化疗后可切除胰腺癌患者 carbohydrate antigen 19-9 的预后价值：一项回顾性队列研究
Yuki Homma,Kentaro Miyake,Yutaro Kikuchi et al.
Yuki Homma et al.
Background: Carbohydrate antigen 19-9 (CA19-9) is widely used to assess treatment response and monitor recurrence alongside imaging. However, the criteria for determining resectability after completion of neoadjuvant ther...
Co-expression of HER2/EGFRvIII/CD44 and Claudin 18.2/CD109 as Novel Prognostic Indicators in Stomach Adenocarcinoma [0.03%]
HER2/EGFRvIII/CD44与Claudin 18.2/CD109共表达作为胃腺癌新型预后标志物的研究
Tina Al Janaby,Said Khelwatty,Izhar Bagwan et al.
Tina Al Janaby et al.
Background: The heterogenous expression of human epidermal growth factor receptor (HER) family members may contribute to poor response to current therapies with HER inhibitors in cancer. This study aimed to explore the co...
Time-to-Treatment Initiation and Its Effect on All-Cause Mortality: Insights From the Surveillance, Epidemiology, and End Results Database [0.03%]
治疗启动时间及其对全因死亡率的影响：来自监测、流行病学和最终结果数据库的见解
Song Peng Ang,Eunseuk Lee,Jia Ee Chia et al.
Song Peng Ang et al.
Background: Delays in cancer treatment initiation can significantly impact survival outcomes, but the magnitude of this effect varies by cancer type, stage, and patient demographics. This study examined the association be...
Assessing the Impact of VEGF -2578C>A (rs699947) and -7C>T (rs2010963) Polymorphisms on Bladder Cancer Susceptibility: A Pilot Study [0.03%]
评估VEGF-2578C>A（rs699947）和-7C>T（rs2010963）多态性对膀胱癌易感性影响的试点研究
Ginanda Putra Siregar,Ida Parwati,Ferry Safriadi et al.
Ginanda Putra Siregar et al.
Background: One of the most common cancers is bladder cancer, characterized by a high mortality rate and a high incidence of recurrence. An identified susceptibility factor for bladder cancer is the presence of single nuc...
Immune Checkpoint Inhibition for Hepatocellular Carcinoma, Cholangiocarcinoma, and Combined Hepatocellular-Cholangiocarcinoma [0.03%]
肝细胞癌、胆管癌和混合型双源癌的免疫检查点抑制疗法
Keiko Shichiri,Kaity H Tung,Kazuaki Takabe et al.
Keiko Shichiri et al.
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma that is composed of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Given its low incidence, there is no standardized treatment protocol or...
Nomograms for Predicting Overall Survival and Cancer-Specific Survival of Small Cell Carcinoma of Ovary Patients: A Retrospective Cohort Study [0.03%]
小细胞卵巢癌患者预后预测图表的建立及验证：回顾性队列研究
Chun Mei Yan,Ya Rong Chen,Hong Fang Li et al.
Chun Mei Yan et al.
Background: This study aimed to develop functional nomograms to predict overall survival (OS) and cancer-specific survival (CSS) of small cell carcinoma of ovary (SCCO). ...
Angiogenesis Is Associated With Aggressive Biology That Counterbalances With Tumor Immunogenicity in Hepatocellular Carcinoma [0.03%]
血管生成与具有侵略性的能够抵消肝细胞癌的肿瘤免疫原性的生物学特征有关
Raj Vaghjiani,Rongrong Wu,Kaity H Tung et al.
Raj Vaghjiani et al.
Background: Hepatocellular carcinoma (HCC) is an arterialized tumor; thus, anti-angiogenesis targeted therapy is in clinical practice. Herein, we hypothesized that HCC with high angiogenesis is biologically aggressive wit...
Increased Sirtuin 6 Activity in Tumor Cells Can Prompt CD4-Positive T-Cell Differentiation Into Regulatory T Cells and Impede Immune Surveillance in the Microenvironment [0.03%]
肿瘤细胞中Sirtuin 6活性的提高可以使CD4阳性T细胞分化为调节性T细胞并妨碍微环境中的免疫监视
Nan Yang Zhang,Wen Yuan Liu,Ke Hua Fang et al.
Nan Yang Zhang et al.
Background: Sirtuin 6 (Sirt6) is expressed at increased levels in many tumors and may be involved in immunoregulation. The present study investigated how Sirt6 in tumor cells affects immune surveillance. ...