Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells [0.03%]
全反式维甲酸在急性髓系白血病细胞中作用机制的研究进展
Hadeel Al Sadoun,Fatimah Alamoudi,Noha Alamoudi et al.
Hadeel Al Sadoun et al.
Background: All-trans retinoic acid (ATRA) has revolutionized the management of acute promyelocytic leukemia (APL) and has generated interest in differentiation therapy as means to reduce reliance on conventional chemothe...
MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment [0.03%]
MiR-301a-3p通过抑制肿瘤细胞和微环境中PTEN的表达促进三阴性乳腺癌的发展进展
Hai Yun Lin,Guang Yan Li,Wen Long Liang et al.
Hai Yun Lin et al.
Background: Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, poses a severe threat to women's health. Adipose-derived stem cells (ADSCs) and microRNAs (miRNAs) critically influence tumor pr...
Tomoyoshi Aoyagi,Gaku Ohira,Koichi Hayano et al.
Tomoyoshi Aoyagi et al.
High-fructose corn syrup (HFCS), a widely used sweetener in processed foods and beverages since the 1970s, has garnered significant attention for its potential role in promoting metabolic disorders and cancer. Unlike glucose, fructose is pr...
A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma [0.03%]
与三级淋巴器官相关的基因标志物可预测肝细胞癌的预后和治疗反应
Xiang Yin Kong,Xiao Hao Li,Xing Long Qiu et al.
Xiang Yin Kong et al.
Background: Hepatocellular carcinoma (HCC) carries a poor prognosis with limited treatment options. Tertiary lymphoid structures (TLS) impact tumor immunity, but their role in HCC requires clarification. This study aimed ...
Reduced Peripheral Blood Natural Killer Cell Proportion Predicts Poor Overall Survival in Advanced Gastric Cancer Patients Treated With Apatinib [0.03%]
外周血天然杀伤细胞比例降低可预测阿帕替尼治疗晚期胃癌患者预后不良
Niu Zhang,Si Yu Hu,Yu Ting Wang et al.
Niu Zhang et al.
Background: Angiogenesis inhibition represents a key therapeutic strategy in oncology, with apatinib showing significant efficacy for advanced gastric cancer (AGC) therapy. Currently, no biomarkers can reliably predict wh...
Successful Immunotherapy Rechallenge Without Recurrence of Hemophagocytic Lymphohistiocytosis in a Patient With Metastatic Endometrial Cancer Previously Treated With Dostarlimab [0.03%]
既往接受过Dostarlimab治疗的转移性子宫内膜癌患者再次进行免疫治疗且未出现噬血细胞性淋巴组织细胞增多症复发的成功案例
Emilie Rollet,Sebastien Puigrenier,Abeer Najem et al.
Emilie Rollet et al.
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal immune hyperactivation syndrome that can be induced by immune checkpoint inhibitors (ICIs). We report a case of a 72-year-old woman with metastatic endometrial carcino...
Efficacy of Tegafur-Uracil Maintenance Therapy in Non-Metastatic Head and Neck Squamous Cell Carcinoma: A Meta-Analysis With Trial Sequential Analysis [0.03%]
替加氟尿嘧啶维持治疗非转移性头颈部鳞状细胞癌有效性的meta分析及序贯试验分析
Hsu-Lin Lee,Cho-Hao Lee,Ming-Shen Dai et al.
Hsu-Lin Lee et al.
Background: Patients with non-metastatic head and neck squamous cell carcinoma (HNSCC) face high risks of recurrence after curative-intent treatment. Maintenance therapy aims to prolong disease control during this vulnera...
Analysis of the SH3-Domain Kinase Binding Protein 1 Predictive Model for Pancreatic Ductal Adenocarcinoma and CCCTC-Binding Factor Transcriptional Regulatory Study [0.03%]
SH3域激酶结合蛋白1的胰腺导管腺癌预测模型分析及CCCTC结合因子转录调控研究
Rui Zhuang Sun,Kun Peng Qiao,Xiao Lian Xu et al.
Rui Zhuang Sun et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies with extremely poor prognosis. This study systematically evaluates the expression patterns, biological functions, and regulator...
Utility of Alpha-Fetoprotein and Protein Induced by Vitamin K Absence or Antagonist-II Kinetics in Predicting Radiologic Response and Survival in Unresectable Hepatocellular Carcinoma Undergoing Immunotherapy [0.03%]
甲胎蛋白和维生素K缺乏或拮抗剂-II诱导的蛋白质在不可切除肝细胞癌免疫治疗中预测影像学反应和生存率的效用
Shou-Wu Lee,Hsin-Ju Tsai,Chia-Chang Chen et al.
Shou-Wu Lee et al.
Background: Alpha-fetoprotein (AFP) is currently the most commonly used biomarker for hepatocellular carcinoma (HCC) surveillance. However, protein induced by vitamin K absence or antagonist-II (PIVKA-II) may have a bette...
Problems in Cancer Genome Medicine: Base Mutations Cause Intron Start Signals, Resulting in Unexpected Splicing [0.03%]
癌症基因组医学问题：碱基突变导致外显子起始信号，引发意外剪接事件
Takuma Hayashi,Ikuo Konishi
Takuma Hayashi
Background: The genetic characteristics of surgically removed cancerous tissues are examined using cancer gene panel testing in cancer genome medicine to detect the pathogenic variants involved in the proliferation and pr...