A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma [0.03%]
与三级淋巴器官相关的基因标志物可预测肝细胞癌的预后和治疗反应
Xiang Yin Kong,Xiao Hao Li,Xing Long Qiu et al.
Xiang Yin Kong et al.
Background: Hepatocellular carcinoma (HCC) carries a poor prognosis with limited treatment options. Tertiary lymphoid structures (TLS) impact tumor immunity, but their role in HCC requires clarification. This study aimed ...
Reduced Peripheral Blood Natural Killer Cell Proportion Predicts Poor Overall Survival in Advanced Gastric Cancer Patients Treated With Apatinib [0.03%]
外周血天然杀伤细胞比例降低可预测阿帕替尼治疗晚期胃癌患者预后不良
Niu Zhang,Si Yu Hu,Yu Ting Wang et al.
Niu Zhang et al.
Background: Angiogenesis inhibition represents a key therapeutic strategy in oncology, with apatinib showing significant efficacy for advanced gastric cancer (AGC) therapy. Currently, no biomarkers can reliably predict wh...
Successful Immunotherapy Rechallenge Without Recurrence of Hemophagocytic Lymphohistiocytosis in a Patient With Metastatic Endometrial Cancer Previously Treated With Dostarlimab [0.03%]
既往接受过Dostarlimab治疗的转移性子宫内膜癌患者再次进行免疫治疗且未出现噬血细胞性淋巴组织细胞增多症复发的成功案例
Emilie Rollet,Sebastien Puigrenier,Abeer Najem et al.
Emilie Rollet et al.
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal immune hyperactivation syndrome that can be induced by immune checkpoint inhibitors (ICIs). We report a case of a 72-year-old woman with metastatic endometrial carcino...
Efficacy of Tegafur-Uracil Maintenance Therapy in Non-Metastatic Head and Neck Squamous Cell Carcinoma: A Meta-Analysis With Trial Sequential Analysis [0.03%]
替加氟尿嘧啶维持治疗非转移性头颈部鳞状细胞癌有效性的meta分析及序贯试验分析
Hsu-Lin Lee,Cho-Hao Lee,Ming-Shen Dai et al.
Hsu-Lin Lee et al.
Background: Patients with non-metastatic head and neck squamous cell carcinoma (HNSCC) face high risks of recurrence after curative-intent treatment. Maintenance therapy aims to prolong disease control during this vulnera...
Analysis of the SH3-Domain Kinase Binding Protein 1 Predictive Model for Pancreatic Ductal Adenocarcinoma and CCCTC-Binding Factor Transcriptional Regulatory Study [0.03%]
SH3域激酶结合蛋白1的胰腺导管腺癌预测模型分析及CCCTC结合因子转录调控研究
Rui Zhuang Sun,Kun Peng Qiao,Xiao Lian Xu et al.
Rui Zhuang Sun et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies with extremely poor prognosis. This study systematically evaluates the expression patterns, biological functions, and regulator...
Utility of Alpha-Fetoprotein and Protein Induced by Vitamin K Absence or Antagonist-II Kinetics in Predicting Radiologic Response and Survival in Unresectable Hepatocellular Carcinoma Undergoing Immunotherapy [0.03%]
甲胎蛋白和维生素K缺乏或拮抗剂-II诱导的蛋白质在不可切除肝细胞癌免疫治疗中预测影像学反应和生存率的效用
Shou-Wu Lee,Hsin-Ju Tsai,Chia-Chang Chen et al.
Shou-Wu Lee et al.
Background: Alpha-fetoprotein (AFP) is currently the most commonly used biomarker for hepatocellular carcinoma (HCC) surveillance. However, protein induced by vitamin K absence or antagonist-II (PIVKA-II) may have a bette...
Problems in Cancer Genome Medicine: Base Mutations Cause Intron Start Signals, Resulting in Unexpected Splicing [0.03%]
癌症基因组医学问题：碱基突变导致外显子起始信号，引发意外剪接事件
Takuma Hayashi,Ikuo Konishi
Takuma Hayashi
Background: The genetic characteristics of surgically removed cancerous tissues are examined using cancer gene panel testing in cancer genome medicine to detect the pathogenic variants involved in the proliferation and pr...
Neoadjuvant Chemotherapy Plus Denosumab Compared to Chemotherapy Alone in Hormonal Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Premenopausal Breast Cancer Patients [0.03%]
HR阳性、HER2阴性绝经前乳腺癌患者新辅助化疗联合地诺单抗治疗与单纯化疗治疗的比较研究
Shereef Ahmed Elsamany,Omima Elemam,Faiza Hassanin et al.
Shereef Ahmed Elsamany et al.
Background: High mRNA expression levels of receptor activator of nuclear factor-kB (RANK) were linked with several adverse prognostic factors in breast cancer. The present study aims to assess the activity of neoadjuvant ...
Invasive Lobular Carcinoma Has Higher Immune Response Than Invasive Ductal Carcinoma in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers [0.03%]
在雌激素受体阳性/人表皮生长因子受体2阴性的乳腺癌中，侵袭性小叶癌的免疫反应高于导管癌
Gabrielle Yee,Rongrong Wu,Takashi Ishikawa et al.
Gabrielle Yee et al.
Background: Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) are two major pathological diagnoses of breast cancer, but few studies have described their differences within luminal (estrogen receptor (E...
Predictors of All-Cause In-Hospital Mortality in Patients With Malignant Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors [0.03%]
恶性胃肠道和胰腺神经内分泌肿瘤患者院内死亡率的预测因素分析
Elvis Obomanu,Tarfa Verinumbe,Tinsae Anebo et al.
Elvis Obomanu et al.
Background: Factors influencing in-hospital mortality in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) remain understudied, highlighting gaps in optimizing acute clinical outcom...