Clinical Utility of Targeted Next-Generation Sequencing for Determining Human Epidermal Growth Factor Receptor 2 Status and Optimizing Targeted Therapy in Breast Cancer [0.03%]
乳腺癌患者HER2状态检测及靶向治疗的临床应用价值——下一代测序技术的评估研究
Yoshimi Hara,Kazuki Moro,Hiroshi Ichikawa et al.
Yoshimi Hara et al.
Background: The development of targeted next-generation sequencing (NGS) technologies has contributed to precision medicine, as evidenced by the growing interest in evaluating human epidermal growth factor receptor 2 (HER...
Evaluating Asparaginase Toxicity in Hispanic Patients With Acute Lymphoblastic Leukemia in a Large Safety-Net Hospital [0.03%]
评估大型安全网医院中西班牙裔急性淋巴细胞白血病患者中阿斯帕根酶毒性的安全性
Dominick Zheng,Marcin Dragan,Jeffrey Jang et al.
Dominick Zheng et al.
Background: Acute lymphoblastic leukemia (ALL) is relatively rare in adults with poor rates of long-term remission. Chemotherapy protocols for adults have been adapted from pediatric protocols, including asparaginase. Whi...
Upregulated E26 Transformation-Specific Variant Transcription Factor 7 in Oral Squamous Cell Carcinoma: Clinicopathological Correlations and Immune Regulatory Mechanisms [0.03%]
上调的E26转化特定变异转录因子7在口腔鳞状细胞癌中的临床病理相关性和免疫调节机制
Xiang Zhi Yong,Jian Di Li,Yu Xing Tang et al.
Xiang Zhi Yong et al.
Background: E26 transformation-specific variant transcription factor 7 (ETV7) is implicated in various cancers, but its role in oral squamous cell carcinoma (OSCC) remains undefined. This study explores the clinicopatholo...
Differentiating Malignant and Healthy Areas in Isolated Kidney Samples Through Infrared Visualization Techniques [0.03%]
红外可视化技术在孤立肾活检标本恶性病变鉴别中的应用研究
Besarion Partsvania,Tamaz Sulaberidze,Alexandre Khuskivadze et al.
Besarion Partsvania et al.
Background: Because partial nephrectomy (PN) may remove malignant tissue while maintaining kidney function, it is currently the gold standard for nephrectomy. However, the blood arteries that supply the kidney are clamped...
Anti-Programmed Cell Death-1 Versus Anti-Programmed Death-Ligand 1 (PD-L1) in PD-L1-Negative Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis [0.03%]
程序性死亡受体1抑制剂与程序性死亡配体1抑制剂治疗程序性死亡配体1阴性晚期非小细胞肺癌的系统评价和 meta 分析
Laith Al-Showbaki,Malak Al-Kasasbeh,Karem Jbarah et al.
Laith Al-Showbaki et al.
Background: Immune checkpoint inhibitors (ICIs) which target programmed cell death-1 (PD-1) receptor or its ligand (PD-L1) are used extensively in non-small cell lung cancer (NSCLC). In this article, we compared the relat...
Adjuvant Therapy Benefits for Patients With Human Epidermal Growth Factor Receptor 2-Positive T1aN0M0 Breast Cancer: A Systematic Review and Meta-Analysis [0.03%]
人表皮生长因子受体2阳性T1aN0M0期乳腺癌患者的辅助治疗收益：系统评价和meta分析
Ezzeldin M Ibrahim,Ahmed A Refae,Ali M Bayer et al.
Ezzeldin M Ibrahim et al.
Background: While the prognosis for patients with human epidermal growth factor receptor 2 (HER2)-positive pT1a-bN0M0 breast cancer is generally favorable, the optimal approach to personalize adjuvant treatment for T1a tu...
Prognostic Significance of Post-Neoadjuvant Chemotherapy Carbohydrate Antigen 19-9 Levels in Patients With Resectable Pancreatic Cancer Treated With S-1 and Gemcitabine: A Retrospective Cohort Study [0.03%]
卡培他滨和吉西他滨新辅助化疗后可切除胰腺癌患者 carbohydrate antigen 19-9 的预后价值：一项回顾性队列研究
Yuki Homma,Kentaro Miyake,Yutaro Kikuchi et al.
Yuki Homma et al.
Background: Carbohydrate antigen 19-9 (CA19-9) is widely used to assess treatment response and monitor recurrence alongside imaging. However, the criteria for determining resectability after completion of neoadjuvant ther...
Co-expression of HER2/EGFRvIII/CD44 and Claudin 18.2/CD109 as Novel Prognostic Indicators in Stomach Adenocarcinoma [0.03%]
HER2/EGFRvIII/CD44与Claudin 18.2/CD109共表达作为胃腺癌新型预后标志物的研究
Tina Al Janaby,Said Khelwatty,Izhar Bagwan et al.
Tina Al Janaby et al.
Background: The heterogenous expression of human epidermal growth factor receptor (HER) family members may contribute to poor response to current therapies with HER inhibitors in cancer. This study aimed to explore the co...
Time-to-Treatment Initiation and Its Effect on All-Cause Mortality: Insights From the Surveillance, Epidemiology, and End Results Database [0.03%]
治疗启动时间及其对全因死亡率的影响：来自监测、流行病学和最终结果数据库的见解
Song Peng Ang,Eunseuk Lee,Jia Ee Chia et al.
Song Peng Ang et al.
Background: Delays in cancer treatment initiation can significantly impact survival outcomes, but the magnitude of this effect varies by cancer type, stage, and patient demographics. This study examined the association be...
Assessing the Impact of VEGF -2578C>A (rs699947) and -7C>T (rs2010963) Polymorphisms on Bladder Cancer Susceptibility: A Pilot Study [0.03%]
评估VEGF-2578C>A（rs699947）和-7C>T（rs2010963）多态性对膀胱癌易感性影响的试点研究
Ginanda Putra Siregar,Ida Parwati,Ferry Safriadi et al.
Ginanda Putra Siregar et al.
Background: One of the most common cancers is bladder cancer, characterized by a high mortality rate and a high incidence of recurrence. An identified susceptibility factor for bladder cancer is the presence of single nuc...