Clinical Significance and Potential Molecular Mechanisms of Angiotensin-Converting Enzyme 2 in Colorectal Cancer [0.03%]
血管紧张素转换酶2在结直肠癌的临床意义及潜在分子机制
Da Tong Zeng,Li Yang,Jia Ying Wen et al.
Da Tong Zeng et al.
Background: Angiotensin-converting enzyme 2 (ACE2) exhibits tumor-suppressive potential in cancers, but its role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate ACE2 expression, clinical sig...
A Comparison of Five-Year Survival Rates Between Thermal Ablation and Hepatic Resection for Colorectal Cancer Metastasis to the Liver: A Systematic Review and Meta-Analysis [0.03%]
热消融与肝切除治疗结直肠癌肝转移5年生存率的系统评价和meta分析
Abdulrahman Alotaibi,Ghala Alshamrani,Hosam Alzobaidi et al.
Abdulrahman Alotaibi et al.
Background: A significant proportion of colorectal liver metastases (CRLMs) are unresectable. This study compares liver resection with thermal ablation. M...
Neurotoxicity of Immunotherapy: Immune Checkpoint Inhibitor-Related Encephalitis vs. Immune Effector Cell-Associated Neurotoxicity Syndrome [0.03%]
免疫治疗的神经毒性：免疫检查点抑制剂相关脑炎与效应细胞相关性神经系统毒性的区别
Takumi Sato,Kohei Chida,Shipra Gandhi et al.
Takumi Sato et al.
Immune checkpoint inhibitors and engineered T-cell therapies such as chimeric antigen receptor T-cell (CAR-T) cells and bispecific T-cell engagers (BiTEs) have revolutionized oncology care, and with them came two neurologic syndromes that l...
E2F5 Overexpression in Laryngeal Squamous Cell Carcinoma: Associations With Neutrophil Extracellular Traps in the Tumor Microenvironment [0.03%]
人喉鳞癌中E2F5过表达与肿瘤微环境中中性粒细胞胞外诱捕网的关系研究
Ke Jun Wu,Feng Zhao,Yu Feng Li et al.
Ke Jun Wu et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck, associated with smoking and excessive alcohol consumption. The objective was to investigate the expression pattern of ...
High CDCP1 Expression Reflects Immune and Stromal Remodeling and Oncogenic Signaling in Pancreatic Ductal Adenocarcinoma [0.03%]
高CDCP1表达反映了胰腺导管腺癌中的免疫和基质重塑及致癌信号转导
Kentaro Miyake,Masanori Oshi,Akira Takenouchi et al.
Kentaro Miyake et al.
Background: CUB domain-containing protein 1 (CDCP1) is implicated in pancreatic ductal adenocarcinoma (PDAC) prognosis, but its relationship to the tumor microenvironment (TME) and oncogenic signaling remains incompletely...
Screening, Risk Reduction Strategies, and Clinical Management of Unaffected Carriers of BRCA1 or BRCA2 Pathogenic Variants [0.03%]
BRCA1/BRCA2基因致病性变异无症状携带者的筛查、风险降低策略和临床管理
Hikmat Abdel-Razeq,Razan Mansour
Hikmat Abdel-Razeq
Breast cancer remains the most common cancer globally, with approximately 5-15% of cases linked to pathogenic variants primarily in BRCA1 or BRCA2. These mutations greatly increase cancer risks, highlighting the critical need for more effec...
The Role and Mechanism of G Protein Subunit Alpha-15 in Colorectal Cancer: An Analysis of Two Hundred Eight Patient Samples and Public Datasets [0.03%]
G蛋白亚基α-15在结直肠癌中的作用和机制：208例患者标本及公共数据集的分析研究
Da Tong Zeng,Zu Yuan Chen,Zuo Yan Ming Li et al.
Da Tong Zeng et al.
Background: Colorectal cancer (CRC) is a tumor with a relatively high incidence rate. The expression of G protein subunit α-15 (GNA15) in CRC and its specific role remain unclear. ...
Maher A Sughayer,Bayan Maraqa,Batool Qura&#x;an et al.
Maher A Sughayer et al.
Background: The 21-gene recurrence score (Oncotype DX) guides adjuvant chemotherapy decisions in early-stage estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative breast cancer. However...
Measuring the Unseen Burden: Immunotherapy and Targeted Therapy Reduce Treatment-Related Time Toxicity in Incurable Malignancies [0.03%]
量化无形的负担：免疫治疗和靶向治疗可减少晚期癌症患者的治疗相关时间毒性
Yuhang Zhou,Madeline Fitzpatrick,Sujata Ojha et al.
Yuhang Zhou et al.
Background: Treatment-related time toxicity (TrTT) poses a cumulative burden on quality of life. We aimed to analyze and quantify the impact of the TrTT on patients with incurable malignancies in our ambulatory oncology c...
Immediate Breast Reconstruction Using an Expanded Latissimus Dorsal Musculocutaneous Flap Without Body Position Change [0.03%]
不改变体位的扩张背阔肌皮瓣即刻乳房再造术
Miwako Miyasaka,Megumi Kiyoi,Aya Shima et al.
Miwako Miyasaka et al.
Background: Breast reconstruction using expanded latissimus dorsal musculocutaneous flap (eLDMC flap) is known for excellent outcome; however, intraoperative change in body position to assess cosmesis prolongs operative t...