E2F5 Overexpression in Laryngeal Squamous Cell Carcinoma: Associations With Neutrophil Extracellular Traps in the Tumor Microenvironment [0.03%]
人喉鳞癌中E2F5过表达与肿瘤微环境中中性粒细胞胞外诱捕网的关系研究
Ke Jun Wu,Feng Zhao,Yu Feng Li et al.
Ke Jun Wu et al.
Background: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck, associated with smoking and excessive alcohol consumption. The objective was to investigate the expression pattern of ...
High CDCP1 Expression Reflects Immune and Stromal Remodeling and Oncogenic Signaling in Pancreatic Ductal Adenocarcinoma [0.03%]
高CDCP1表达反映了胰腺导管腺癌中的免疫和基质重塑及致癌信号转导
Kentaro Miyake,Masanori Oshi,Akira Takenouchi et al.
Kentaro Miyake et al.
Background: CUB domain-containing protein 1 (CDCP1) is implicated in pancreatic ductal adenocarcinoma (PDAC) prognosis, but its relationship to the tumor microenvironment (TME) and oncogenic signaling remains incompletely...
Screening, Risk Reduction Strategies, and Clinical Management of Unaffected Carriers of BRCA1 or BRCA2 Pathogenic Variants [0.03%]
BRCA1/BRCA2基因致病性变异无症状携带者的筛查、风险降低策略和临床管理
Hikmat Abdel-Razeq,Razan Mansour
Hikmat Abdel-Razeq
Breast cancer remains the most common cancer globally, with approximately 5-15% of cases linked to pathogenic variants primarily in BRCA1 or BRCA2. These mutations greatly increase cancer risks, highlighting the critical need for more effec...
The Role and Mechanism of G Protein Subunit Alpha-15 in Colorectal Cancer: An Analysis of Two Hundred Eight Patient Samples and Public Datasets [0.03%]
G蛋白亚基α-15在结直肠癌中的作用和机制：208例患者标本及公共数据集的分析研究
Da Tong Zeng,Zu Yuan Chen,Zuo Yan Ming Li et al.
Da Tong Zeng et al.
Background: Colorectal cancer (CRC) is a tumor with a relatively high incidence rate. The expression of G protein subunit α-15 (GNA15) in CRC and its specific role remain unclear. ...
Maher A Sughayer,Bayan Maraqa,Batool Qura&#x;an et al.
Maher A Sughayer et al.
Background: The 21-gene recurrence score (Oncotype DX) guides adjuvant chemotherapy decisions in early-stage estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative breast cancer. However...
Measuring the Unseen Burden: Immunotherapy and Targeted Therapy Reduce Treatment-Related Time Toxicity in Incurable Malignancies [0.03%]
量化无形的负担：免疫治疗和靶向治疗可减少晚期癌症患者的治疗相关时间毒性
Yuhang Zhou,Madeline Fitzpatrick,Sujata Ojha et al.
Yuhang Zhou et al.
Background: Treatment-related time toxicity (TrTT) poses a cumulative burden on quality of life. We aimed to analyze and quantify the impact of the TrTT on patients with incurable malignancies in our ambulatory oncology c...
Immediate Breast Reconstruction Using an Expanded Latissimus Dorsal Musculocutaneous Flap Without Body Position Change [0.03%]
不改变体位的扩张背阔肌皮瓣即刻乳房再造术
Miwako Miyasaka,Megumi Kiyoi,Aya Shima et al.
Miwako Miyasaka et al.
Background: Breast reconstruction using expanded latissimus dorsal musculocutaneous flap (eLDMC flap) is known for excellent outcome; however, intraoperative change in body position to assess cosmesis prolongs operative t...
Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells [0.03%]
全反式维甲酸在急性髓系白血病细胞中作用机制的研究进展
Hadeel Al Sadoun,Fatimah Alamoudi,Noha Alamoudi et al.
Hadeel Al Sadoun et al.
Background: All-trans retinoic acid (ATRA) has revolutionized the management of acute promyelocytic leukemia (APL) and has generated interest in differentiation therapy as means to reduce reliance on conventional chemothe...
MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment [0.03%]
MiR-301a-3p通过抑制肿瘤细胞和微环境中PTEN的表达促进三阴性乳腺癌的发展进展
Hai Yun Lin,Guang Yan Li,Wen Long Liang et al.
Hai Yun Lin et al.
Background: Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, poses a severe threat to women's health. Adipose-derived stem cells (ADSCs) and microRNAs (miRNAs) critically influence tumor pr...
Tomoyoshi Aoyagi,Gaku Ohira,Koichi Hayano et al.
Tomoyoshi Aoyagi et al.
High-fructose corn syrup (HFCS), a widely used sweetener in processed foods and beverages since the 1970s, has garnered significant attention for its potential role in promoting metabolic disorders and cancer. Unlike glucose, fructose is pr...