The Role and Mechanism of G Protein Subunit Alpha-15 in Colorectal Cancer: An Analysis of Two Hundred Eight Patient Samples and Public Datasets [0.03%]
G蛋白亚基α-15在结直肠癌中的作用和机制：208例患者标本及公共数据集的分析研究
Da Tong Zeng,Zu Yuan Chen,Zuo Yan Ming Li et al.
Da Tong Zeng et al.
Background: Colorectal cancer (CRC) is a tumor with a relatively high incidence rate. The expression of G protein subunit α-15 (GNA15) in CRC and its specific role remain unclear. ...
Maher A Sughayer,Bayan Maraqa,Batool Qura&#x;an et al.
Maher A Sughayer et al.
Background: The 21-gene recurrence score (Oncotype DX) guides adjuvant chemotherapy decisions in early-stage estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative breast cancer. However...
Measuring the Unseen Burden: Immunotherapy and Targeted Therapy Reduce Treatment-Related Time Toxicity in Incurable Malignancies [0.03%]
量化无形的负担：免疫治疗和靶向治疗可减少晚期癌症患者的治疗相关时间毒性
Yuhang Zhou,Madeline Fitzpatrick,Sujata Ojha et al.
Yuhang Zhou et al.
Background: Treatment-related time toxicity (TrTT) poses a cumulative burden on quality of life. We aimed to analyze and quantify the impact of the TrTT on patients with incurable malignancies in our ambulatory oncology c...
Immediate Breast Reconstruction Using an Expanded Latissimus Dorsal Musculocutaneous Flap Without Body Position Change [0.03%]
不改变体位的扩张背阔肌皮瓣即刻乳房再造术
Miwako Miyasaka,Megumi Kiyoi,Aya Shima et al.
Miwako Miyasaka et al.
Background: Breast reconstruction using expanded latissimus dorsal musculocutaneous flap (eLDMC flap) is known for excellent outcome; however, intraoperative change in body position to assess cosmesis prolongs operative t...
Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells [0.03%]
全反式维甲酸在急性髓系白血病细胞中作用机制的研究进展
Hadeel Al Sadoun,Fatimah Alamoudi,Noha Alamoudi et al.
Hadeel Al Sadoun et al.
Background: All-trans retinoic acid (ATRA) has revolutionized the management of acute promyelocytic leukemia (APL) and has generated interest in differentiation therapy as means to reduce reliance on conventional chemothe...
MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment [0.03%]
MiR-301a-3p通过抑制肿瘤细胞和微环境中PTEN的表达促进三阴性乳腺癌的发展进展
Hai Yun Lin,Guang Yan Li,Wen Long Liang et al.
Hai Yun Lin et al.
Background: Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, poses a severe threat to women's health. Adipose-derived stem cells (ADSCs) and microRNAs (miRNAs) critically influence tumor pr...
Tomoyoshi Aoyagi,Gaku Ohira,Koichi Hayano et al.
Tomoyoshi Aoyagi et al.
High-fructose corn syrup (HFCS), a widely used sweetener in processed foods and beverages since the 1970s, has garnered significant attention for its potential role in promoting metabolic disorders and cancer. Unlike glucose, fructose is pr...
A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma [0.03%]
与三级淋巴器官相关的基因标志物可预测肝细胞癌的预后和治疗反应
Xiang Yin Kong,Xiao Hao Li,Xing Long Qiu et al.
Xiang Yin Kong et al.
Background: Hepatocellular carcinoma (HCC) carries a poor prognosis with limited treatment options. Tertiary lymphoid structures (TLS) impact tumor immunity, but their role in HCC requires clarification. This study aimed ...
Reduced Peripheral Blood Natural Killer Cell Proportion Predicts Poor Overall Survival in Advanced Gastric Cancer Patients Treated With Apatinib [0.03%]
外周血天然杀伤细胞比例降低可预测阿帕替尼治疗晚期胃癌患者预后不良
Niu Zhang,Si Yu Hu,Yu Ting Wang et al.
Niu Zhang et al.
Background: Angiogenesis inhibition represents a key therapeutic strategy in oncology, with apatinib showing significant efficacy for advanced gastric cancer (AGC) therapy. Currently, no biomarkers can reliably predict wh...
Successful Immunotherapy Rechallenge Without Recurrence of Hemophagocytic Lymphohistiocytosis in a Patient With Metastatic Endometrial Cancer Previously Treated With Dostarlimab [0.03%]
既往接受过Dostarlimab治疗的转移性子宫内膜癌患者再次进行免疫治疗且未出现噬血细胞性淋巴组织细胞增多症复发的成功案例
Emilie Rollet,Sebastien Puigrenier,Abeer Najem et al.
Emilie Rollet et al.
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal immune hyperactivation syndrome that can be induced by immune checkpoint inhibitors (ICIs). We report a case of a 72-year-old woman with metastatic endometrial carcino...