Proliferation Inhibited by Genipin in Human Leukemia K562 Cells: Involvement of Uncoupling Protein 2 in Mitochondrial Damage [0.03%]
细胞增殖抑制：苦柯茋通过线粒体通道蛋白2损伤线粒体抑制人K562细胞的增殖作用
Ying Zhou,Rui Sun,Zi Wen Zhang et al.
Ying Zhou et al.
Background: Uncoupling protein 2 (UCP2) is essential for maintaining redox homeostasis and regulating energy metabolism. Abnormal expression of UCP2 has been associated with various tumors, including leukemia. Genipin (GE...
Correlation Between PIK3R1 Expression and Cell Growth in Human Breast Cancer Cell Line BT-474 and Clinical Outcomes [0.03%]
PIK3R1表达与人乳腺癌细胞系BT-474细胞增殖的相关性及其临床意义
Yi-Fang Tsai,Jiun-I Lai,Chun-Yu Liu et al.
Yi-Fang Tsai et al.
Background: While mutations in the PIK3CA gene play important roles in human breast carcinogenesis, PIK3R1 gene alterations are recognized as actionable mutations for clinical cancer treatment. We aimed to elucidate the r...
Expression Profile of Thymidine Kinase Genes in Cervical Squamous Cell Carcinoma Confirmed by Various Detection Methods [0.03%]
多种检测方法确认宫颈鳞癌中胸苷激酶基因表达谱
Cai Xia Liang,Ya Jun Pang,Man Yu Chen et al.
Cai Xia Liang et al.
Background: Thymidine kinases (TKs) are key enzymes involved in DNA synthesis and repair, with alterations in their expression associated with various cancers. Thymidine kinase 1 (TK1) and TK2 are cytosolic enzyme protein...
Activity-Regulated Cytoskeleton-Associated Protein Gene Expression Is Associated With High Infiltration of Stromal Cells and Immune Cells, but With Less Cancer Cell Proliferation and Better Overall Survival in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers [0.03%]
活动调节的细胞骨架相关蛋白基因表达与乳腺癌基质和免疫细胞高浸润、但癌症细胞增殖少以及预后更好相关：绝经后雌激素受体阳性/HER2阴性患者的优势更明显
Gabrielle Yee,Rongrong Wu,Masanori Oshi et al.
Gabrielle Yee et al.
Background: Peritumoral lidocaine infiltration prior to excision is associated with better survival in breast cancer (BC), which led us to hypothesize that innervation to the tumor affects its biology and patient survival...
VEGFA Gene Expression in Breast Cancer Is Associated With Worse Prognosis, but Better Response to Chemotherapy and Immunotherapy [0.03%]
乳腺癌中VEGFA基因表达与预后不良相关，但对化疗和免疫治疗的反应更好
Pia Sharma,Kohei Chida,Rongrong Wu et al.
Pia Sharma et al.
Background: Vascular endothelial growth factor-A (VEGFA) is a key inducer of angiogenesis, responsible for generating new blood vessels in the tumor microenvironment (TME) and facilitating metastasis. Notably, Avastin, wh...
Effect of Whey Protein Supplementation on Postoperative Outcomes After Gynecological Cancer Surgery: A Randomized Controlled Trial [0.03%]
一项随机对照试验评估术前补充乳清蛋白对妇科癌症患者手术结局影响的效果
Wiranchana Chitti,Putsarat Insin,Nisa Prueksaritanond
Wiranchana Chitti
Background: Whey protein's biochemical properties make it an ideal nutritional supplement for patients with cancer, especially in perioperative care. Thus, the present study aims to assess the efficacy of whey protein sup...
Discordant Responses Between Imaging Examination and Surgical Pathology of Head and Heck Squamous Cell Carcinoma After Neoadjuvant Immunotherapy Combined With Chemotherapy [0.03%]
新辅助免疫联合化疗后头颈部鳞癌影像学与术病理反应不一致分析
Yu Dong Ning,Yi Xuan Song,Yu Qin He et al.
Yu Dong Ning et al.
Background: We here investigated the value of imaging examination in evaluating tumor remission-based surgery in patients with head and neck squamous cell carcinoma (HNSCC), who had undergone neoadjuvant immunotherapy com...
The Prevalence of 5-Fluorouracil and Capecitabine Cardiotoxicity: A Systematic Review and Meta-Analysis [0.03%]
氟尿嘧啶和卡培他滨心血管毒性的流行率：系统回顾和荟萃分析
Bannawich Sapapsap,Poomipat Thongnoi,Anchana Pongpun et al.
Bannawich Sapapsap et al.
Background: The incidence of cardiotoxicity events in patients who use 5-fluorouracil (5-FU) and capecitabine monotherapy remains unclear since previous studies reported the prevalence in patients who used combination reg...
Causal Relationships Between Gut Microbiota, Immune Cell and Pancreatic Cancer: A Two-Step, Two-Sample Mendelian Randomization Study [0.03%]
基于孟德尔随机化研究的胰腺癌与肠道菌群、免疫细胞因果关系研究
Si Ming Wang,Ming Feng Zhang,Qian Hui Pan et al.
Si Ming Wang et al.
Background: Gut microbiota (GM) is associated with both the occurrence and development of pancreatic cancer (PC), and immune cells potentially play a role in this process. This study sought to evaluate the causative effec...
The Association of Preoperative Prognostic Nutritional Index With Survival Outcome in Ovarian Clear Cell Cancer [0.03%]
术前营养评价指数与卵巢透明细胞癌患者生存结局的关系分析
Nisa Prueksaritanond,Kittisak Petchsila,Putsarat Insin
Nisa Prueksaritanond
Background: The preoperative prognostic nutritional index (PPNI) has been investigated as a prognostic indicator in various cancers including epithelial ovarian cancer (EOC). However, its prognostic relevance in epithelia...