TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer [0.03%]
TP53丢失通过激活mTORC1和抑制自噬驱动免疫原性冷的结直肠癌发生发展
Eunseuk Lee,Dana Al-Assi,Randy Rivera-Rueda et al.
Eunseuk Lee et al.
Background: Microsatellite-stable colorectal cancer (MSS CRC) is typically resistant to immune checkpoint blockade and remains an "immune-cold" disease. Wild-type p53 is known to restrain mTOR signaling and support autoph...
Identification of Genes and Construction of Prognostic Model of Lung Adenocarcinoma Based on Propionate Metabolism-Related Genes [0.03%]
基于丙酸代谢相关基因的肺癌腺癌预后模型的构建及关键基因鉴定
Min Min Li,Wei Jia Fu,Ying Zhou et al.
Min Min Li et al.
Background: Dysregulation of propionate metabolism can enhance the invasive properties of lung adenocarcinoma (LUAD) cells and increase their metastatic potential. Therefore, we constructed a predictive model based on pro...
Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells [0.03%]
多组学和单细胞孟德尔随机化揭示VNN2在静息自然杀伤细胞中肺腺癌中的潜在作用
Zhi Chun Xue,Jing Lin,Jian Hui Wu et al.
Zhi Chun Xue et al.
Background: We aimed to evaluate the potential association between genetically predicted vanin-2 (VNN2) expression and lung adenocarcinoma (LUAD) risk, and to explore the immune cell subtype that may underlie this relatio...
Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer [0.03%]
双向孟德尔随机化分析揭示自身免疫疾病与结直肠癌间的因果关系
Shuang Liu,Kun Chen,Yue Qi Wang et al.
Shuang Liu et al.
Background: Observational studies have reported associations between autoimmune diseases (AIDs) and colorectal cancer (CRC), but whether these relationships are causal remains unclear. ...
Strong Signals of Adverse Events in Tyrosine Kinase Inhibitor Therapy for Liver Cancer Treatment [0.03%]
肝癌酪氨酸激酶抑制剂治疗的不良事件强信号分析研究
Wen Xuan Zhou,Jun Hao Fan,Qian Wen Ni et al.
Wen Xuan Zhou et al.
Background: This study was to identify strong adverse event (AE) signals associated with four tyrosine kinase inhibitors (TKIs) (sorafenib, regorafenib, lenvatinib, and cabozantinib), and compare these signals with regula...
Clinical Outcomes and Prognostic Factors in Metastatic Triple-Negative Breast Cancer: A Real-World Data Analysis [0.03%]
转移性三阴性乳腺癌的临床结局和预后因素：真实世界数据分析
Moe Itakura,Yoshiya Horimoto,Yumiko Ushiyama et al.
Moe Itakura et al.
Background: Metastatic triple-negative breast cancer (mTNBC) is associated with poor outcomes, and therapeutic strategies remain challenging. This study analyzed real-world data to clarify clinical characteristics, treatm...
Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer [0.03%]
B细胞激酶Btk表达反映乳腺癌中免疫细胞浸润和细胞增殖
Tamrah AlRammah,Rongrong Wu,Kohei Chida et al.
Tamrah AlRammah et al.
Background: Bruton's tyrosine kinase (BTK) is a downstream mediator in B-cell receptor (BCR) signaling and is essential for B-cell differentiation and proliferation. BTK inhibitors are approved and in clinical use for hem...
Analysis of Prognosis and Immune Microenvironment of Protein Kinase C Substrate 80K-H in Diabetic Lung Cancer Patients [0.03%]
蛋白激酶C底物80K-H在糖尿病肺癌患者中的预后及免疫微环境分析
Xiang Ying Li,Yue Feng,Cun Feng Li et al.
Xiang Ying Li et al.
Background: A substantial association has been established between diabetes and an elevated risk of lung cancer. This study aimed to elucidate the prognosis and characterize alterations in the immune microenvironment link...
Functional and Survival Outcomes of Partial Versus Radical Nephrectomy in Renal Cell Carcinoma Patients With Pre-Existing Chronic Kidney Disease: A Real-World Study [0.03%]
慢性肾脏病患者部分肾切除术与根治性肾切除术的功能和生存结局：一项基于真实世界的研究
Luan Kinh Thai,Viet Quang Luu,Sam Minh Thai
Luan Kinh Thai
Background: Managing renal cell carcinoma (RCC) in patients with pre-existing chronic kidney disease (CKD) or a solitary kidney requires balancing oncologic control with maximal renal functional preservation. This study a...
Characterization of Acute Myeloid Leukemia With t(16;21) Translocation: Cytogenetic, Molecular, and Immunophenotypic Findings [0.03%]
急性髓系白血病伴16号和21号染色体易位的特征：细胞遗传学、分子及免疫表型发现
Milder Bravo-Davila,Dayana Espinoza-Rodrigez,Javier Orejon-Huarancca et al.
Milder Bravo-Davila et al.
Background: Acute myeloid leukemia (AML) with t(16;21) translocation is an infrequent hematological neoplasia. This study aimed to describe the cytogenetic, molecular and immunophenotypic profiles of this disease. ...