Comprehensive Analysis of Ozanimod-Related Adverse Events Based on the FAERS Database [0.03%]
基于FAERS数据库的ozanimod相关不良事件综合分析
Zi Ru Zhou,Qun Yan Zhou,Yue Shen et al.
Zi Ru Zhou et al.
Background: Ozanimod, a selective sphingosine-1-phosphate receptor modulator, has been approved for the treatment of moderately to severely active ulcerative colitis (UC) and relapsing forms of multiple sclerosis (MS). Ho...
Hypoxia-Induced Exosomal miR-1225-5p Accelerates Colorectal Cancer Progression by Targeting Carboxypeptidase M [0.03%]
缺氧诱导的外泌体miR-1225-5p通过靶向羧肽酶M促进结直肠癌进展
Yue Hui Guo,Qing Yun Zhu,Shi Wei Chen et al.
Yue Hui Guo et al.
Background: Colorectal cancer (CRC) remains a considerable public health burden worldwide, with hypoxia emerging as a key driver of tumor aggressiveness. Within the hypoxic tumor microenvironment (TME), exosomes function ...
Integrated Bioinformatics Analysis Identifies NCAPG2 as an Immune-Related Prognostic Biomarker in Breast Cancer [0.03%]
整合生物信息学分析鉴定出NCAPG2作为乳腺癌免疫相关预后生物标志物
Jia Li,Qian Wang,Hao Qiao
Jia Li
Background: Non-SMC condensin II complex subunit G2 (NCAPG2) is an important molecule in regulating chromosome segregation of mitosis and acts as an oncogene and biomarker in various tumors. This study aimed to explore th...
Rana Salman Anjum,Kazuaki Takabe
Rana Salman Anjum
Homologous recombination deficiency (HRD) has transformed the therapeutic landscape of breast cancer through the clinical success of poly(ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy. Central to this vulnerabilit...
Spatial Immune Remodeling Across the Gallbladder Carcinogenesis Spectrum: A Multicenter Digital Pathology Study [0.03%]
基于多中心数字化病理的大范围胆囊癌变免疫图谱研究
Tamta Kveliashvili,George Didava,George Burkadze et al.
Tamta Kveliashvili et al.
Background: Gallbladder carcinoma (GBC) is the most aggressive malignancy of the biliary tract and is commonly associated with late diagnosis and early metastatic dissemination. Although the morphological sequence of gall...
Transcription Factor MAX Regulates Liver Cancer Cell Growth, Migration, Invasion, and Epithelial-Mesenchymal Transition by Promoting SF3A3 Expression [0.03%]
转录因子MAX通过促进SF3A3表达调节肝癌细胞增殖、迁移、侵袭及上皮间质转化
Gui Zhou,Mei Yu Dai,Xiang Chen et al.
Gui Zhou et al.
Background: The regulatory relationship between transcription factor MAX and splicing factor SF3A3 in hepatocellular carcinoma (HCC) is unknown. We investigated whether MAX directly regulates SF3A3 and their functional ro...
Divergent Prognostic Impact of Histopathological Features and Combined Hematological-Biochemical Indices in Rectal Versus Colorectal Cancer: A Single-Center Study [0.03%]
基于单中心队列的直肠癌与结肠癌预后影响因素分析：内镜、病理及血清学指标的影响差异性研究
Vladica Cuk,Jovan Juloski,Marijana Gacinovic et al.
Vladica Cuk et al.
Background: Colorectal cancer is frequently analyzed as a single disease entity despite recognized biological and clinical differences between colon and rectal tumors. This study investigated whether systemic inflammatory...
Human Epidermal Growth Factor Receptor 2 Negative, Low, and Overexpression in Breast Cancer Patients: Study on Recurrence-Free and Overall Survival [0.03%]
乳腺癌患者人类表皮生长因子受体2阴性、低表达和过表达与无复发生存期和总生存期的关系：一项回顾性研究
Widyanti Soewoto,Kristanto Yuli Yarso,Ida Bagus Budhi Surya Adnyana et al.
Widyanti Soewoto et al.
Background: Human epidermal growth factor receptor 2 (HER2) expression is a key prognostic marker in breast cancer. Recently, HER2-low breast cancer has emerged as a potentially distinct subgroup; however, its prognostic ...
Neurogenic Small Molecules Reverse miR-342-3p-Mediated Tumorigenesis in Renal Cell Carcinoma [0.03%]
神经源性小分子逆转miR-342-3p介导的肾细胞癌肿瘤发生发展
Yi Zhou Ye,Zhang Ming Du,Hong Wei Chen et al.
Yi Zhou Ye et al.
Background: Cigarette smoking is a major established risk factor for clear cell renal cell carcinoma (ccRCC), yet the molecular mediators linking smoking exposure to tumor biology remain incompletely understood. Here, we ...
The Association Between Potential Nuclear Factor-Kappa B1 Gene Polymorphism rs28362491 and miR-206 Level in Patients With Acute Lymphoblastic Leukemia [0.03%]
急性淋巴细胞白血病患者潜在核因子κB1基因多态性位点rs28362491与miR-206水平的相关性研究
Isra Muradi,Jehad Alhmoud,Moath Al-Qaraleh et al.
Isra Muradi et al.
Background: microRNAs (miRNAs) and the nuclear factor-kappa B1 (NF-κB1) signaling pathway play a critical role in leukemogenesis. The miR-206 and NF-κB1-94 ATTG polymorphism (rs28362491) have a potential impact on cance...