Epitranscriptomic regulation in the progression of cancer and platinum resistance [0.03%]
表观转录组学修饰在肿瘤发生发展及铂类耐药中的作用机制研究
Pavol Harvanik,Terézia Hudáková,Martina Šemeláková et al.
Pavol Harvanik et al.
Epitranscriptomic regulation has emerged as a critical mechanism in cancer biology, particularly in the development of chemoresistance. RNA modifications including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), ...
Prediction of heart arrhythmia onset in patients with ICD using machine learning algorithms [0.03%]
基于机器学习算法的心室颤动病人的心律失常发病预测
Agnieszka Kitlas Golińska,Krzysztof Mnich,Andrzej Przybylski et al.
Agnieszka Kitlas Golińska et al.
Purpose: The current study uses machine learning algorithms to predict the onset of cardiac arrhythmia in patients with implantable cardioverter-defibrillators (ICD). We aimed to check how far in advance the onset of arrh...
Liver-related autoantibodies in Wilson disease: increased prevalence and unclear clinical significance [0.03%]
威尔森病中的肝相关自身抗体：较高的检出率及其临床意义尚不清楚
Magdalena Antczak-Kowalska,Anna Członkowska,Agnieszka Cudna et al.
Magdalena Antczak-Kowalska et al.
Purpose: Wilson disease (WD) is a rare disorder of copper metabolism, primarily affecting the liver and brain. While the toxic effects of copper are well established, the role of autoantibodies in the disease's pathophysi...
Co-occurrence and multi-system clustering of respiratory and allergic symptoms in Polish school-aged children: a Global Asthma Network Cross-sectional Study [0.03%]
波兰学龄儿童呼吸系统和过敏症状的共现及多系统聚类：一项全球哮喘网络横断面研究
Charles Prendergast,Agnieszka Jarosińska,Agnieszka Kalita et al.
Charles Prendergast et al.
Purpose: Allergic and asthma-related respiratory symptoms frequently co-occur in childhood and may reflect shared inflammatory mechanisms. However, population-based data on their overlap in Central and Eastern Europe rema...
The glutathione transferase omega 1-1 GSTO1*A140D polymorphism is associated with unfavourable prognosis in patients with thymoma and myasthenia gravis [0.03%]
谷胱甘肽转移酶ω基因多态性与胸腺瘤合并重症肌无力患者预后的关系研究
Simona Piaggi,Vittoria Carnicelli,Eleonora Pardini et al.
Simona Piaggi et al.
Purpose: Thymomas are rare organotypic tumors frequently associated with immune-related paraneoplastic syndromes. The genetic alterations of thymomas are largely unknown and rely on general transcription factor I (GTF2I) ...
Crosstalk between thyroid dysfunction and kidney dysfunction in intensive care unit patients [0.03%]
ICU患者甲状腺功能不全与肾功能不全的相互作用关系
Alicja Filipczyk,Karol P Steckiewicz,Seweryn Niewiadomski et al.
Alicja Filipczyk et al.
This scientific review explores the intricate bidirectional relationship (crosstalk) between thyroid dysfunction and kidney dysfunction within the context of the intensive care unit (ICU). We discuss how critical illness and acute kidney in...
Etiology of heart failure across the ejection fraction spectrum and association with mortality - insight from the HEart failuRe ObsErvational Study (HEROES) [0.03%]
射血分数不同水平的心衰病因与预后的关系——来自心力衰竭观察研究（HEROES）的见解
Michał Tarnowski,Karolina Molenda,Robert Morawiec et al.
Michał Tarnowski et al.
Purpose: The associations between heart failure (HF) etiology in patients with HF with preserved ejection fraction (HFpEF), HF with mildly reduced ejection fraction (HFmrEF), HF with reduced ejection fraction (HFrEF) and ...
Evaluation of antitumor potential of novel semicarbazide-based derivatives: cytotoxicity, angiogenesis modulation, and cell cycle effects in in vitro and in vivo models [0.03%]
新型半卡巴腙衍生物抗肿瘤潜力的评估：体内外模型中的细胞毒性、血管生成调节和细胞周期效应
Łucja Justyna Walczak,Monika Gawrońska-Grzywacz,Marta Arczewska et al.
Łucja Justyna Walczak et al.
Purpose: Previous studies demonstrated that semicarbazide derivatives 1-(2-chlorophenylcarbonyl)-4-(2,4-dichlorophenyl)semicarbazide (AW8) and 1-(2-chlorophenylcarbonyl)-4-(3,4-dichlorophenyl)semicarbazide (AW12) possess ...
AMPK signaling in cancer: dual roles, molecular mechanisms, and therapeutic potential [0.03%]
AMPK信号通路在癌症中的双重作用、分子机制及治疗潜力
Miribane Dërmaku-Sopjani,Rifat Morina,Faton Sermaxhaj et al.
Miribane Dërmaku-Sopjani et al.
Purpose: Adenosine monophosphate-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis that integrates metabolic stress signals arising from nutrient deprivation and other adverse condition...
Minimally invasive percutaneous procedure for the treatment of a contained cervical disc herniation - a preliminary prospective study [0.03%]
颈椎包容性椎间盘突出症的微创治疗的一项前瞻性初步研究
Magdalena Rybaczek,Barbara Polityńska-Lewko,Zenon Mariak et al.
Magdalena Rybaczek et al.
Purpose: This study evaluated the efficacy of a minimally invasive cervical procedure that combines percutaneous nucleoplasty, annuloplasty, and manual nucleotomy in patients with internal annular rupture or contained dis...