Zbigniew Kmieć
Zbigniew Kmieć
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis [0.03%]
黄芪甲苷IV介导的内皮祖细胞外泌体通过miR-21/PTEN轴促进自噬并抑制高血糖损伤的内皮细胞凋亡
Wu Xiong,Xin-Ling Huang,Cheng-Yu Li et al.
Wu Xiong et al.
Introduction: As one of the basic components of Astragalus, Astragaloside IV (AS-IV) has a protective effect on endothelial injury caused by diabetes. AS-IV stimulated endothelial progenitor cells (EPCs) to secrete exosom...
Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis [0.03%]
右美托咪定通过抑制TLR4/MyD88/NF-κB信号缓解溃疡性结肠炎小鼠模型的肠道屏障功能障碍和炎症反应
Xiaojin Ye,Huailiang Xu,Yuan Xu
Xiaojin Ye
Introduction: Ulcerative colitis (UC) is a nonspecific intestinal inflammatory disease. Dexmedetomidine (DEX) is a selective alpha 2-adrenergic receptor agonist commonly used for analgesia and sedation in intensive care u...
Wedelolactone ameliorates synovial inflammation and cardiac complications in a murine model of collagen-induced arthritis by inhibiting NF-κB/NLRP3 inflammasome activation [0.03%]
wedelolactone通过抑制NF-κB/NLRP3炎性小体活化改善胶原诱导的关节炎小鼠模型的滑膜炎症和心脏并发症
Jingjing Cao,Yanhui Ni,Xiaoran Ning et al.
Jingjing Cao et al.
Introduction: Rheumatoid arthritis (RA) is an autoimmune disorder associated with joint damage and attendant cardiovascular complications. Wedelolactone (Wed), derived from Eclipta alba, possesses anti-inflammatory activi...
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase [0.03%]
miR-328-5p通过靶向脂肪酸合酶抑制人骨髓间充质干细胞的成脂分化
Xingnuan Li,Shan He,Ping Wu et al.
Xingnuan Li et al.
Introduction: Adipogenesis, a highly coordinated process regulated by numerous effectors, is largely responsible for the quantity and size of adipocytes. Attenuation of adipocyte differentiation has been proposed as a via...
Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome axis orchestrates optimal trafficking of hematopoietic stem progenitors cells [0.03%]
新型证据表明P2X1嘌呤能受体-NLRP3炎性小体轴调控造血干细胞谱系定向的最优机制
Kamila Bujko,Mateusz Adamiak,Ahmed Abdelbaset-Ismail et al.
Kamila Bujko et al.
Introduction: Our previous research demonstrated P2X purinergic receptors as important extracellular adenosine triphosphate (eATP) sensing receptors promoting the trafficking of hematopoietic stem progenitor cells (HSPCs)...
Wnt5a/Ror2 promotes vascular smooth muscle cells proliferation via activating PKC [0.03%]
Wnt5a/Ror2通过激活PKC促进血管平滑肌细胞增殖
Yaning Shi,Hongfang Li,Jia Gu et al.
Yaning Shi et al.
Introduction: Abnormal proliferation of vascular smooth muscle cells (VSMCs) can cause various vascular diseases, such as atherosclerosis, restenosis, and pulmonary hypertension. However, the effect and underlying mechani...
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome [0.03%]
DHEA诱导的多囊卵巢综合征小鼠模型中HDAC5通过抑制卵巢血管生成发挥治疗作用
Ying Wang,Yu Wang,Yao Chen et al.
Ying Wang et al.
Introduction: Abnormal ovarian angiogenesis is a common feature of polycystic ovary syndrome (PCOS), a typical endocrine disorder affecting women of reproductive age. Histone deacetylase 5 (HDAC5) has been documented as a...
Predictive role of NKCD56bright cells in monitoring the progression of chronic lymphocytic leukemia during treatment [0.03%]
NK细胞亚群在慢性淋巴细胞白血病监测中的预测作用
Katarzyna Blachnio,Beata Grygalewicz,Renata Woroniecka et al.
Katarzyna Blachnio et al.
Introduction: Standard treatment for chronic lymphocytic leukemia (CLL) has experienced a dramatic change over the last few years. Until recently, CLL was treated using chemoimmunotherapy (CIT) with anti-CD20 monoclonal a...
HIPK2 attenuates bleomycin-induced pulmonary fibrosis by suppressing the Wnt/β-catenin signaling pathway [0.03%]
HIPK2通过抑制Wnt/β-连环蛋白信号通路缓解博来霉素诱导的肺纤维化
Fangfang Wang,Yanan Zhang,Jing Ren et al.
Fangfang Wang et al.
Introduction: The present study aimed to investigate the effect of homeodomain interacting protein kinase 2 (HIPK2) on pulmonary fibrosis and the probable mechanisms. ...