Wedelolactone ameliorates synovial inflammation and cardiac complications in a murine model of collagen-induced arthritis by inhibiting NF-κB/NLRP3 inflammasome activation [0.03%]
wedelolactone通过抑制NF-κB/NLRP3炎性小体活化改善胶原诱导的关节炎小鼠模型的滑膜炎症和心脏并发症
Jingjing Cao,Yanhui Ni,Xiaoran Ning et al.
Jingjing Cao et al.
Introduction: Rheumatoid arthritis (RA) is an autoimmune disorder associated with joint damage and attendant cardiovascular complications. Wedelolactone (Wed), derived from Eclipta alba, possesses anti-inflammatory activi...
MiR-328-5p inhibits the adipogenic differentiation of hMSCs by targeting fatty acid synthase [0.03%]
miR-328-5p通过靶向脂肪酸合酶抑制人骨髓间充质干细胞的成脂分化
Xingnuan Li,Shan He,Ping Wu et al.
Xingnuan Li et al.
Introduction: Adipogenesis, a highly coordinated process regulated by numerous effectors, is largely responsible for the quantity and size of adipocytes. Attenuation of adipocyte differentiation has been proposed as a via...
Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome axis orchestrates optimal trafficking of hematopoietic stem progenitors cells [0.03%]
新型证据表明P2X1嘌呤能受体-NLRP3炎性小体轴调控造血干细胞谱系定向的最优机制
Kamila Bujko,Mateusz Adamiak,Ahmed Abdelbaset-Ismail et al.
Kamila Bujko et al.
Introduction: Our previous research demonstrated P2X purinergic receptors as important extracellular adenosine triphosphate (eATP) sensing receptors promoting the trafficking of hematopoietic stem progenitor cells (HSPCs)...
Wnt5a/Ror2 promotes vascular smooth muscle cells proliferation via activating PKC [0.03%]
Wnt5a/Ror2通过激活PKC促进血管平滑肌细胞增殖
Yaning Shi,Hongfang Li,Jia Gu et al.
Yaning Shi et al.
Introduction: Abnormal proliferation of vascular smooth muscle cells (VSMCs) can cause various vascular diseases, such as atherosclerosis, restenosis, and pulmonary hypertension. However, the effect and underlying mechani...
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome [0.03%]
DHEA诱导的多囊卵巢综合征小鼠模型中HDAC5通过抑制卵巢血管生成发挥治疗作用
Ying Wang,Yu Wang,Yao Chen et al.
Ying Wang et al.
Introduction: Abnormal ovarian angiogenesis is a common feature of polycystic ovary syndrome (PCOS), a typical endocrine disorder affecting women of reproductive age. Histone deacetylase 5 (HDAC5) has been documented as a...
Predictive role of NKCD56bright cells in monitoring the progression of chronic lymphocytic leukemia during treatment [0.03%]
NK细胞亚群在慢性淋巴细胞白血病监测中的预测作用
Katarzyna Blachnio,Beata Grygalewicz,Renata Woroniecka et al.
Katarzyna Blachnio et al.
Introduction: Standard treatment for chronic lymphocytic leukemia (CLL) has experienced a dramatic change over the last few years. Until recently, CLL was treated using chemoimmunotherapy (CIT) with anti-CD20 monoclonal a...
HIPK2 attenuates bleomycin-induced pulmonary fibrosis by suppressing the Wnt/β-catenin signaling pathway [0.03%]
HIPK2通过抑制Wnt/β-连环蛋白信号通路缓解博来霉素诱导的肺纤维化
Fangfang Wang,Yanan Zhang,Jing Ren et al.
Fangfang Wang et al.
Introduction: The present study aimed to investigate the effect of homeodomain interacting protein kinase 2 (HIPK2) on pulmonary fibrosis and the probable mechanisms. ...
Activation of the JAK1/STAT1 signaling pathway is associated with peroxiredoxin 6 expression levels in human epididymis epithelial cells [0.03%]
激活的JAK1/STAT1信号通路与人附睾上皮细胞中过氧化氢酶6表达水平相关
Hui Shi,Xiaoyu Liu,Yanwei Wang et al.
Hui Shi et al.
Introduction: Peroxiredoxin 6 (Prdx6) is widely expressed in mammalian tissues. Our previous study demonstrated that Prdx6 was expressed in human epididymis, present in human seminal fluid, and in spermatozoa. The protect...
Celastrol alleviates murine lupus nephritis via inducting CD4+Foxp3+ regulatory T cells [0.03%]
雷公藤红素通过诱导CD4+Foxp3+调节性T细胞达到治疗小鼠狼疮性肾炎的效果
Guangbo Xiang,Kai Shi,Jinjun Wang
Guangbo Xiang
Introduction: Lupus nephritis (LN) is an autoimmune glomerulonephritis secondary to systemic lupus erythematosus. Commonly, immunosuppressive agents are required for treating LN. However, frequent use of conventional immu...
Serum exosomal microRNA-370-3p and microRNA-196a-5p are potential biomarkers for the diagnosis and prognosis of hepatocellular carcinoma [0.03%]
血清外泌体微RNA-370-3p和微RNA-196a-5p是肝细胞癌诊断和预后潜在生物标志物
Yaning Wei,Qian Zhang,Lin An et al.
Yaning Wei et al.
Introduction: Evidence has shown that some microRNAs (miRNAs) play a role in tumorigenesis of hepatocellular carcinoma (HCC). Herein, we aimed to evaluate the diagnostic and prognostic values of serum exosomal miR-370-3p ...