Diosmetin ameliorates osteoarthritic inflammation in vivo and ECM macromolecules degradation in interleukin-1β-stimulated murine chondrocytes through the Nrf2/NF-κB pathway [0.03%]
染料木素通过Nrf2/NF-κB途径改善体内骨关节炎性状及细胞外基质大分子物质的降解
Liang Qian,Chuang Li,Hong Liu et al.
Liang Qian et al.
Introduction: Osteoarthritis (OA) is a prevailing degenerative disease in elderly population and can lead to severe joint dysfunction. Studies have revealed various pharmacological activities of diosmetin, including the a...
Makgotso Nchodu,Robin du Preez,Alice Efuntayo et al.
Makgotso Nchodu et al.
Introduction: Adolescents tend to experiment with ethanol which often results in heavy episodic drinking patterns leading to serious health concerns later in life. Chronic ethanol use damages renal tissue, promotes collag...
Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy [0.03%]
mitofusin 2通过调节线粒体功能和自噬抑制高糖诱导的人晶状上皮细胞凋亡
Yuan-Yi Guo,Jiang-Yue Zhao,Han-Rong Li et al.
Yuan-Yi Guo et al.
Introduction: Diabetic cataract (DC) is a common ocular complication of diabetes. Mitofusin 2 (MFN2), a mitochondrial fusion protein, is involved in the pathogenesis of cataract and diabetic complications. However, its ro...
Effects of bone marrow mesenchymal stem cell-conditioned medium on the proliferation and migration of liposarcoma cells [0.03%]
骨髓间充质干细胞诱导培养液对脂肪肉瘤细胞增殖和迁移能力的影响
Hua Chen,Na Sha,Ning Liu et al.
Hua Chen et al.
Introduction: Liposarcoma constitutes a prevalent subtype of soft tissue sarcoma, represents approximately 20% of all sarcomas. However, conventional chemotherapeutic agents have shown restricted effectiveness in treating...
Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1 [0.03%]
IGF2BP1抑制通过PTBP1减轻子宫内膜异位症的发展
Yanlin Su,Wencai Tian,Li Cheng et al.
Yanlin Su et al.
Introduction: Endometriosis (EMs), manifested by pain and infertility, is a chronic inflammatory disease. The precise pathophysiology of this disease remains uncertain. Insulin-like growth factor-2 mRNA-binding protein 1 ...
Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling [0.03%]
人参皂苷Rg1通过SIRT1/NF-κB信号传导在脂多糖诱导的小鼠内毒素血症中发挥肾保护作用
Yadan Hu,Chao Xiang,Dong Zhang et al.
Yadan Hu et al.
Introduction: During sepsis, the kidney is one of the most vulnerable organs. Sepsis-associated acute kidney injury (S-AKI) is hallmarked by renal inflammation, apoptosis, and oxidative injury. Ginsenoside Rg1 (Rg1) is a ...
Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil [0.03%]
蒙古仓鼠视觉皮层中一氧化氮合酶神经元的免疫细胞化学定位研究
Xin-Yu Kuai,Gwang-Jin Jeong,Chang-Jin Jeon
Xin-Yu Kuai
Introduction: Nitric oxide (NO) is present in various cell types in the central nervous system and plays a crucial role in the control of various cellular functions. The diurnal Mongolian gerbil is a member of the rodent ...
Diagnostic utility of immunocytochemistry by using liquid-based cytology (LBC) slides [0.03%]
液基细胞学(LBC)涂片免疫细胞化学的诊断作用
Ozben Yalcin,Senay Erdogan-Durmus,Enver Yarikkaya
Ozben Yalcin
Introduction: Cytological specimens, such as fine needle aspirations (FNAs) and exfoliative cytology samples, are minimally invasive options for diagnostic purposes. Liquid-based cytology (LBC), originally designed for ce...
miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation [0.03%]
miRNA-192-5p通过抑制神经元凋亡和神经炎症以靶向Dyrk1a来减轻MCAO小鼠的脑损伤
Wei He,De-Long Meng,Dan Yang et al.
Wei He et al.
Introduction: Ischemic stroke (IS) is a leading cause of disability and mortality worldwide. Several studies have demonstrated the involvement of microRNAs (miRNAs) in brain diseases. miRNA-192-5p is a regulatory molecule...
Correlation between stromal Th and Tc lymphocytes and PD-L1 expression in early breast cancer tumors [0.03%]
早期乳腺癌肿瘤中瘤周Th和Tc淋巴细胞与PD-L1表达的相关性研究
Jelena Vučinić,Ljiljana Vučković,Janja Raonić
Jelena Vučinić
Introduction: Prognostic and predictive value of PD-L1 as a biomarker in breast cancer remains controversial. While some studies suggest its association with negative prognostic parameters, others reported a highly signif...