Enhanced migration and adhesion protein expression by polyethylene glycol 4-modified SVVYGLR peptide in an in vitro human gingival fibroblast wound healing model [0.03%]
聚乙二醇4修饰的SVVYGLR肽在体外人龈纤维母细胞伤口愈合模型中的迁移及黏附相关蛋白表达增强作用
Peiying Xiong,Chengcheng Yu,Zhihui Chen et al.
Peiying Xiong et al.
Introduction: This study was aimed at exploring the effect of four units of polyethylene glycol (PEG4)-modified Ser-Val-Val-Tyr-Gly-Leu-Arg (SVVYGLR) peptide (SV peptide) on the proliferative potential and migrative capab...
MiR-494-3p knockdown promotes osteogenic differentiation of bone marrow mesenchymal stem cells in ovariectomised rats by targeting Sirt1/TLR4/NF-κB pathway [0.03%]
miR-494-3p敲低通过靶向Sirt1/TLR4/NF-κB通路促进卵巢切除大鼠骨髓间充质干细胞成骨分化
Jianping Lei,Song Guo,Jiabing Kuang et al.
Jianping Lei et al.
Introduction: Osteoporosis is a bone disease characterised by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture. MicroRNAs have been found to play an important role in osteoporosis. Mic...
Mechanisms of alleviating sepsis-induced rat lung and kidney damage by inhibiting expression of miRNA-939 [0.03%]
抑制miRNA-939表达减轻脓毒症诱导的大鼠肺肾损伤的机制研究
Anwaier Apizi,Jian Li,Yan Li et al.
Anwaier Apizi et al.
Introduction: Sepsis, a life-threatening condition caused by a host response that goes out of control, leads to severe organ dysfunction. MicroRNA 939 (miRNA-939) plays a pivotal role in this process by post-transcription...
Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway [0.03%]
SIRT1上调通过FoxO1/β-catenin信号途径改善氧化应激下椎间盘髓核细胞凋亡的作用研究
Hongtao Hu,Sheng Wang,Haijun Teng et al.
Hongtao Hu et al.
Introduction: Age-related degenerative changes in intervertebral discs (IVDs) can lead to lower back pain, and even paralysis. This topic is therefore garnering growing attention in an increasingly ageing society. The oxi...
Nintedanib alleviates hyperoxia-induced lung injury via targeting NF-κB signalling pathway in rat model of bronchopulmonary dysplasia [0.03%]
尼替尼布通过靶向NF-κB信号途径缓解支气管肺发育不良大鼠模型中的高氧诱导的肺损伤
Rui Hao,Yuping Li,Junhui Li et al.
Rui Hao et al.
Introduction: Bronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in premature infants. Hyperoxia is the main pathogenic factor of BPD. Nintedanib is a small-molecule tyrosine kinase inhibitor that ha...
Expression of O-GlcNAcylation in pulp tissue and DPSCs of healthy dental organs [0.03%]
健康牙器官的牙髓组织和DPSC中的O-甘露糖基化表达分析
María Cristina Franco-Arellanes,Perla Xóchitl Toledo-Valdes,Cynthia Díaz-Hernández et al.
María Cristina Franco-Arellanes et al.
Introduction: O-GlcNAcylation is a post-translational modification in which a single N-Acetyl-D-Glucosamine (GlcNAc) molecule is added to Ser or Thr residues of proteins. The O-N-acetylglucosaminyl transferase (OGT) enzym...
Inhibition of STAT1 alleviates oxidative damage in retinal pigment epithelial cells and exhibits neuroprotective effects in autoimmune optic neuritis by upregulating IFI30 lysosomal thiol reductase [0.03%]
STAT1的抑制通过上调IFI30溶酶体硫醇还原酶减轻视网膜色素上皮细胞的氧化损伤并在自身免疫性 optic neuritis 中表现出神经保护作用
Siqi Ma,Jiajia Yuan
Siqi Ma
Introduction: . Oxidative damage-induced retinal pigment epithelial (RPE) cell apoptosis and optic nerve inflammation and demyelination are closely related to the pathogenesis of optic neuritis (ON). STAT1 has been found ...
CCL19 promotes TNF-alpha/IFN-gamma-induced production of cytokines by targeting CCR7/NF-κB signalling in HaCaT cells [0.03%]
CCL19通过靶向CCR7/NF-κB信号通路促进TNF-α/IFN-γ诱导的HaCaT细胞中细胞因子产生
Ying Zeng,Xiaoqi Nie,Yunhua Deng
Ying Zeng
Introduction: Atopic dermatitis (AD) is the most common allergic skin disease. The dysfunction of keratinocytes is closely associated with AD progression. Nevertheless, the specific functions of CC chemokine ligand 19 (CC...
OGFr overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells [0.03%]
过表达OGFr通过活化P16和P21抑制HepG2细胞增殖及迁移的抗肝癌作用
Zhezhu Jin,Yongjun Jin
Zhezhu Jin
Introduction: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, ...
Anti-atherosclerotic effects of LncRNA NEXN-AS1 by regulation of the canonical inflammasome pathway of pyroptosis via NEXN [0.03%]
长链非编码RNA NEXN-AS1通过调节NEXN介导的经典的炎性小体途径抑制动脉粥样硬化形成的作用及机制研究
Fei Chen,Yun-Yong Lin,Rui Chen et al.
Fei Chen et al.
Introduction: . Pyroptosis is closely related to many chronic diseases including atherosclerosis, but the potential pathomechanisms are still unclear. This research aimed to explore how lncRNAs may contribute to pyroptosi...