Ya-Nan Ma,Kenji Karako,Peipei Song et al.
Ya-Nan Ma et al.
Herpes Zoster (HZ), caused by the reactivation of the varicella-zoster virus (VZV), is a common infectious disease. Recent studies suggest a potential association between HZ and the development of dementia, particularly Alzheimer's disease ...
Clinical benefits of rapid initiation of antiretroviral therapy within 14 days for newly diagnosed late-presentation people living with human immunodeficiency virus (PLWH) [0.03%]
快速启动抗逆转录病毒治疗对新诊断的晚期HIV感染患者临床收益：一项多中心队列研究
Xiang Zhang,Hongjing Guan,Xiaoyun Di et al.
Xiang Zhang et al.
This study evaluated the impact of initiating antiretroviral therapy (ART) within 14 days compared to starting after 14 days in newly diagnosed, late-presenting people living with human immunodeficiency virus (PLWH). A total of 1,538 PLWH w...
Generation and characterization of a humanized GJB2 p.V37I knock-in mouse model for studying age-related hearing loss [0.03%]
人源化GJB2 p.V37I基因敲入小鼠模型的建立及对年龄相关性听力损失的研究
Yiding Yu,Yue Li,Jingyun Li et al.
Yiding Yu et al.
Age-related hearing loss (ARHL) has been closely linked to genetic factors, with studies identifying the p.V37I mutation in the GJB2 gene as a potential contributor to ARHL. To investigate this, we generated a humanized p.V37I mutant mouse ...
Silkworm (Bombyx mori) as a novel infection model for fish-derived Aeromonas hydrophila [0.03%]
鱼源型气单胞菌新型感染模型——家蚕模型研究
Atsushi Miyashita,Kazuhiro Mikami,Hiroto Nakajima et al.
Atsushi Miyashita et al.
Aeromonas hydrophila is a significant pathogenic bacterium in aquaculture and the ornamental fish industry, causing lethal infections in fish and contributing to rising drug resistance. This leads to substantial economic losses and undersco...
Practical training reduces aspiration-linked gaps in pressure ulcer education for pharmacy students [0.03%]
实践培训可减少药学专业学生压疮教育中的抱负联系差距
Shingo Kondo,Ririka Mima,Rira Okui et al.
Shingo Kondo et al.
Expectations for pharmacists' contribution and involvement in pressure ulcer pharmacotherapy are growing. This study aimed to not only clarify the effects of incorporating practical training on the use of topical medications into clinical p...
Dietary supplementation with Nopalea cochenillifera enhances fecal mucin production and modulates serum immunoglobulin levels in a dose- and time-dependent manner in BALB/c mice [0.03%]
仙人掌科乔巴里属植物的膳食补充可剂量和时间依赖性地促进BALB/C小鼠粪便黏蛋白产生并调节血清免疫球蛋白水平
Sayaka Yokoyama,Hana Kozai,Amane Kikuchi et al.
Sayaka Yokoyama et al.
The aim of this study was to determine the time-dependent effects of the prickly pear (Nopalea cochenillifera) on the intestinal environment and immune function in BALB/c mice, which exhibit a predominant T helper 2 immune response. Five-we...
Effects of patient age on the therapeutic effects of GIP/GLP-1 receptor agonists (tirzepatide) [0.03%]
患者年龄对GIP / GLP-1受体激动剂( tirzepatide )疗效的影响
Atsushi Ishimura,Yutaka Shimizu,Naohiro Yabuki
Atsushi Ishimura
Glucagon-like peptide-1 receptor agonist (GLP-1RA) has attracted attention owing to its hypoglycemic and weight-loss effects, and various dosage forms are available in the market. Recently, glucose-dependent insulin secretion-stimulating po...
Gepotidacin: The first-in-class triazaacenaphthylene antibiotic approved for the treatment of uncomplicated urinary tract infections [0.03%]
特序雅定：一类三氮杂苊啶类抗生素，用于治疗无并发症的泌尿道感染
Shasha Hu,Haizhou Yu,Jianjun Gao
Shasha Hu
Uncomplicated urinary tract infection (uUTI) is a common bacterial infection in women. While the condition typically has a favorable prognosis, the widespread use of antibiotics has led to increasingly bacterial resistance, reducing the eff...
Fitusiran: The first approved siRNA therapy for hemophilia via reducing plasma antithrombin levels [0.03%]
Fitusiran：首个通过降低血浆抗凝血酶水平来治疗甲型血友病的siRNA疗法
Daoran Lu,Fangzhou Dou,Jianjun Gao
Daoran Lu
Hemophilia is a coagulation disorder caused by deficiencies in clotting factors and is primarily classified into hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficiency). Current treatment relies predominantly on replac...
Efficacy of etanercept biosimilar switching from etanercept reference product, using ultrasound and clinical data in outcomes of real world therapy (ESCORT-NGSK Study) [0.03%]
从使用超声和临床数据的现实世界疗法结果看依那西普生物类似药与原研药互换的有效性（ESCORT-NGSK研究）
Remi Sumiyoshi,Shin-Ya Kawashiri,Toshimasa Shimizu et al.
Remi Sumiyoshi et al.
This study aimed to investigate in detail the efficacy of switching from etanercept reference product (RP) to etanercept biosimilar in patients with rheumatoid arthritis (RA) under real-world clinical conditions using clinical indices and m...