Quercetin as a multifaceted therapeutic agent in recurrent pregnancy loss: Mechanisms and clinical perspectives [0.03%]
檞皮素在复发性妊娠丢失中的多重治疗作用：机制和临床视角
Qing Qi,Jing Zhou,Jing Wang et al.
Qing Qi et al.
In recent years, there has been an escalating incidence of recurrent pregnancy loss (RPL), imposing substantial psychosocial and economic burdens on families. Despite extensive investigations, approximately 50% of cases remain idiopathic, u...
Abortion adverse events associated with adalimumab, etanercept, ustekinumab, and dupilumab during pregnancy: A pharmacovigilance study based on FDA adverse event reporting system [0.03%]
基于美国FDA不良事件报告系统的眼科药物妊娠期流产不良事件信号检测研究
Qian Liu,Yang Wang,Panwei Hu et al.
Qian Liu et al.
Biologics are essential for managing immune-related inflammatory diseases during pregnancy to prevent disease progression and adverse pregnancy outcomes. However, data on the safety of biologics in a broader population are limited. This stu...
The pTau217/Aβ1-42 plasma ratio: The first FDA-cleared blood biomarker test for diagnosis of Alzheimer's disease [0.03%]
pTau217/Aβ1-42血浆比率：FDA批准的第一种用于诊断阿尔茨海默病的血液生物标志物检测方法
Shasha Hu,Haizhou Yu,Jianjun Gao
Shasha Hu
As the most prevalent form of dementia, Alzheimer's disease (AD) represents a major public health challenge. Early diagnosis is crucial to delaying disease progression, and yet the gold standard for detection of biomarkers - cerebral positr...
Primary cutaneous lymphoma is a microsatellite stable tumor: An analysis of microsatellite instability [0.03%]
原发性皮肤淋巴瘤是一种微卫星稳定的肿瘤：对微卫星不稳定性分析的研究
Saki Maeda-Otsuka,Myangat Tselmeg Mijiddorj,Ikko Kajihara et al.
Saki Maeda-Otsuka et al.
A deficiency in DNA mismatch repair (MMR) leads to microsatellite instability (MSI), which is associated with a favorable response to immune checkpoint inhibitors (ICIs), and the Promega MSI Analysis System is approved as a companion diagno...
Kampo medicine in the management of menopausal symptoms: A narrative review of therapeutic potential [0.03%]
汉方药在绝经症状管理中的治疗潜力：综述性研究
Yuanzheng Liu,Susumu Kobayashi,Ling Wang et al.
Yuanzheng Liu et al.
Menopausal symptoms primarily result from ovarian dysfunction and declining estrogen levels, leading to multisystem disorders. Although hormone therapy remains the most effective treatment, its long-term use is associated with significant r...
Opsin 3-mediated regulation of blue light-induced β-hexosaminidase release from mast cells [0.03%]
Opsin 3介导的蓝光诱导的大鼠肥大细胞β-岩藻糖苷酶释放的调节作用研究
Hiroyuki Yamamoto,Miki Kiryu,Yoshikazu Sawaguchi et al.
Hiroyuki Yamamoto et al.
The human body is constantly exposed to light from the environment, and intense light is a source of skin inflammation. Although cellular responses to high-energy ultraviolet light have long been reported, the photoresponsive mechanism occu...
Acoltremon: The first TRPM8 agonist approved for the treatment of dry eye disease [0.03%]
Acoltremon：首个获准治疗干眼病的TRPM8激动剂
Yang Zhou,Wenzhu Zhang,Fusheng Sun
Yang Zhou
Dry eye disease (DED) is a common ocular surface disorder that markedly affects the quality of life (QoL) of patients. Conventional treatments for DED were unable to meet current medical needs. Acoltremon, a transient receptor potential mel...
Immune modulation and improved systemic performance of phosphate-functionalized nanogels for antifungal therapy [0.03%]
用于抗真菌治疗的磷化纳米凝胶的免疫调节和改善全身性能
Theresa Vogel,Yidong Yu,Thorsten Keller et al.
Theresa Vogel et al.
Phosphate functionalization of nanogels (NGs), originally designed to enhance interactions with fungal pathogens, also significantly influences their immune interactions and systemic behaviour. In this study, we investigated how phosphate-m...
Discovery of SARS-CoV-2 papain-like protease inhibitors through machine learning and molecular simulation approaches [0.03%]
基于机器学习和分子模拟的SARS-CoV-2蛋白酶抑制剂的发现
Li Li,Jinyang Li,Quanling Zhang et al.
Li Li et al.
The papain-like protease (PLpro), a cysteine protease found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), plays a crucial role in viral replication by cleaving the viral polyproteins and interfering with the host's innate...
Trpa1 knockout favors colon tumorigenesis in dextran sulfate sodium (DSS)-induced colitis mice [0.03%]
Trpa1基因敲除使葡聚糖硫酸钠诱导的结肠炎小鼠更易患结肠肿瘤
Fangzhou Dou,Shasha Hu,Daoran Lu et al.
Fangzhou Dou et al.
Chronic inflammation in the colon has been recognized as a key pathogenic mechanism driving colorectal cancer development. TRPA1 (transient receptor potential ankyrin 1), a key member of the TRP cation channel superfamily, is closely implic...