Serum lipid levels serve as predictors for osteoporosis or osteopenia in postmenopausal women: A meta-analysis of observational studies [0.03%]
血清脂质水平可作为绝经后妇女骨质疏松症或低骨量的预测因素：观察性研究的系统评价和 Meta 分析
Feijun Ye,Yanlin Zhang,Ziqin Chen et al.
Feijun Ye et al.
This meta-analysis summarizes the differences in serum lipid levels among postmenopausal women with osteopenia, osteoporosis, and normal bone mass, aiming to establish reliable lipid markers for predicting bone loss in postmenopausal women....
Piezo1 mediates calcium ion influx, glucose transporter 4 translocation, and glucose uptake in adipocytes under low-frequency vibration [0.03%]
Piezo1介导的钙离子流入、葡萄糖转运蛋白4易位及脂肪细胞在低频振动下的葡萄糖摄取
Dazhuang Huang,Daijiro Haba,Sanai Tomida et al.
Dazhuang Huang et al.
Diabetic foot ulcers (DFUs) are associated with a high risk of amputation and mortality, necessitating effective wound-healing interventions. Low-frequency vibration (LFV) therapy promotes wound healing by increasing glucose metabolism; how...
Bovine lactoferrin intake prevents hepatic injury in a mouse model of non-alcoholic steatohepatitis induced by choline and methionine deficiency [0.03%]
反式乳铁蛋白通过调控肠道屏障功能和内毒素血症预防胆碱、甲硫氨酸缺乏小鼠非酒精性脂肪肝病发病机制的研究
Ryoken Aoki,Kentaro Ishido,Megumi Furukawa et al.
Ryoken Aoki et al.
Lactoferrin, a multifunctional protein found in breast milk, is important for the regulation of immune function. Non-alcoholic steatohepatitis (NASH), which is characterized by hepatitis and fibrosis, has no established drug treatment. In t...
A pilot study investigating the efficiency of an Internet of things (IOT)-aided warehouse management system in the management of consumables for the operating room in a Chinese setting [0.03%]
一项关于物联网(IoT)辅助型仓库管理系统在中国手术室耗材管理中应用效率的试点研究
Guimei Zhang,Qi Wang,Li Zhao et al.
Guimei Zhang et al.
The aim of this study was to investigate the value of an Internet of things (IOT)-aided warehouse management system (IAWMS) to improve the efficiency of consumables management for the operating room (OR). Indices in three domains (error ale...
Evaluation of electrospun composite biomaterial and porcine small intestine submucosa patch in open inguinal herniorrhaphy: A prospective, randomized, single-blind, controlled, multicenter, 72-month clinical study [0.03%]
可电纺复合生物材料与猪小肠黏膜下组织补片用于开放式腹股沟疝修补的前瞻性、随机、单盲、对照、多中心临床研究（72个月）
Zhiying Qiu,Liang Fang,Shaojie Li et al.
Zhiying Qiu et al.
The aim of this study was to compare postoperative complications and long-term clinical efficacy of electrospun composite biomaterial and porcine small intestine submucosa (SIS) patch in open inguinal herniorrhaphy. A prospective, randomize...
Implementation and evaluation of a structured lecture-based training program for early-career pharmacists [0.03%]
实习药师结构化讲授式培训项目的设计与评估
Yuma Nonomiya,Masashi Nakamura,Tomonori Nakamura et al.
Yuma Nonomiya et al.
Since 2022, the Cancer Institute Hospital of the Japanese Foundation for Cancer Research (JFCR) has participated in a postgraduate clinical training program organized by the Japanese Society of Hospital Pharmacists. Subsequently, the traini...
Anti-Mycobacterium avium complex activities of streptcytosine analogs from a marine actinomycete as nucleoside antibiotics [0.03%]
来源于海洋放线菌的链丝黴菌素碱基类似物抗麻风分枝杆菌活性研究
Natsuki Oshima,Akiho Yagi,Hiroyuki Yamazaki et al.
Natsuki Oshima et al.
To examine the potential of nucleoside antibiotics as therapeutic agents against Mycobacterium avium complex (MAC), the in vitro and in vivo anti-MAC activities of streptcytosine A (1), plicacetin (2), and bamicetin (3) derived from a marin...
Revitalizing Japan's biomedical ecosystem: Policy initiatives, challenges, and future directions [0.03%]
重振日本的生物医学生态系统：政策举措、挑战及未来方向
Ryo Okuyama
Ryo Okuyama
Japan's international competitiveness in biomedical innovation is declining, as evidenced by its expanding trade deficit in pharmaceuticals. One reason for this is that the ecosystem connecting academic research outcomes to startups and new...
Switching from originator infliximab to biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving clinical remission (the IFX-SIRIUS study I): An interventional, multicenter, open-label, single-arm clinical trial with clinical, ultrasound and biomarker assessments [0.03%]
日本类风湿关节炎患者从原研英夫利西单抗换用生物类似药英夫利西单抗的真实世界研究（IFX-SIRIUS研究Ⅰ）：一项干预性、多中心、开放标签、单组临床试验及超声和生物标志物评估
Toshimasa Shimizu,Shin-Ya Kawashiri,Tomohiro Koga et al.
Toshimasa Shimizu et al.
Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the presence of autoantibodies, with infliximab (IFX), the first biological disease-modifying anti-rheumatic drug (DMARD) targeting tumor necrosis factor α, sign...
Telisotuzumab vedotin: The first-in-class c-Met-targeted antibody-drug conjugate granted FDA accelerated approval for treatment of non-squamous non-small cell lung cancer (NSCLC) [0.03%]
特拉situmab vedotin：美国FDA加速批准的首个针对c-Met的抗体药物偶联物，用于非鳞状非小细胞肺癌(NSCLC)治疗
Chenru Zhao,Daoran Lu,Jianjun Gao
Chenru Zhao
Telisotuzumab vedotin represents a clinically important antibody-drug conjugate (ADC) that received accelerated approval from the US Food and Drug Administration in May 2025, establishing it as the first-in-class targeted therapy for adult ...