Paltusotine: The first selective nonpeptide agonist of somatostatin receptor 2 (SSTR2) for the treatment of acromegaly [0.03%]
帕鲁妥丁：首个特异性的非肽类生长抑素受体亚型2(SSTR2)激动剂用于治疗肢端肥大症
Yueyi Sun,Daoran Lu,Jianjun Gao
Yueyi Sun
Acromegaly is an endocrine disorder characterized by abnormal enlargement of the extremities and internal organs resulting from excessive secretion of growth hormone (GH) by the pituitary gland, which in turn leads to elevated levels of ins...
Food, medicine, and cosmetic homology: A comprehensive review of bioactive components, functions, and applications of Torreya grandis [0.03%]
TORREYAgrandis食品、医药及化妆品同源性：活性成分、功能和应用的全面综述
Xiaoyan Cui,Chuanyin Shi,Yan Sun
Xiaoyan Cui
Torreya grandis (T. grandis) is one of the evergreen tree species in China. The kernels of T. grandis have been used as traditional medicine and food for thousands of years in China. In recent years, it has also been developed as raw materi...
Development and reliability assessment of a liquid-phase measurement for skin taurine using skin blotting [0.03%]
基于皮肤蘸取技术的皮肤 tau 氨酸液相检测方法建立及其可靠性评估
Katsunori Kato,Kazuhiro Ogai,Yoko Hasegawa et al.
Katsunori Kato et al.
Skin taurine is an indicator of dehydration and can be noninvasively collected through skin blotting. However, conventional taurine measurement using ninhydrin raises safety and specificity concerns, limiting its application in point-of-car...
Purification and characterization of a novel antioxidant protein from Arca subcrenata Lischke [0.03%]
来源于ArksubcrenataLischke的抗氧化蛋白质的分离纯化及性质鉴定
Qing Yan,Hui Shi,Yue Gao et al.
Qing Yan et al.
A novel protein, G1H2GC2, was isolated from Arca subcrenata Lischke using homogenization and ammonium sulfate precipitation, and further purified by several column chromatography techniques including diethyl-aminoethanol (DEAE) Sepharose Fa...
Changing epidemiology of respiratory pathogens since 2020: Shenzhen case study and global perspectives [0.03%]
2020年以来呼吸系统病原体的流行病学变化——深圳案例研究与全球视角
Chun Chen,Houming Liu,Jiaye Liu et al.
Chun Chen et al.
The coronavirus disease 2019 (COVID-19) pandemic fundamentally disrupted global respiratory virus epidemiology through widespread non-pharmaceutical interventions. Analysis of a tertiary hospital in Shenzhen (2021-2024) reveals profound alt...
Comparing gene-targeting efficiency of Agrobacterium tumefaciens-mediated transformation and electroporation in the pathogenic fungus Trichosporon asahii JCM2466 [0.03%]
植物病原真菌Trichosporon asahii JCM2466中农杆菌介导转化和电击转化效率的比较
Yasuhiko Matsumoto,Mei Nakayama,Yuta Shimizu et al.
Yasuhiko Matsumoto et al.
Trichosporon asahii is a pathogenic fungus that causes severe deep-seated fungal infections in neutropenic patients. Ku70, a key component of the non-homologous end-joining (NHEJ) pathway involved in the repair of DNA double-strand breaks, ...
Solid phase extraction and high-performance liquid chromatographic determination of lazertinib in human plasma [0.03%]
人血浆中Lazertinib的固相萃取及高效液相色谱测定法研究
Yoshito Gando,Takeo Yasu
Yoshito Gando
Lazertinib is a novel third-generation tyrosine kinase inhibitor (TKI) developed for the treatment of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). Reports on previous EGFR-TKIs have detailed significant...
Indicators of a moist wound environment and care to maintain a moist environment for early healing: A scoping review [0.03%]
湿润伤口环境的指标及维持早期愈合所需湿性环境的护理：一项综述研究
Mao Kunimitsu,Karin Izumi,Yume Kawamizu et al.
Mao Kunimitsu et al.
Although maintaining a moist environment is important for wound healing, excess moisture can delay wound healing. Furthermore, recommended assessment methods for moist environments in the latest consensus guidelines are subjective. This sco...
TRPC6 expression is negatively correlated with breast cancer progression [0.03%]
TRPC6表达与乳腺癌进展呈负相关关系
Yifei Ma,Guoning Li,Haoyang Yu et al.
Yifei Ma et al.
The transient receptor potential channel 6 (TRPC6), a Ca2+-permeable, non-selective cation channel, is a potential drug target widely expressed in most human tissues. However, the role of TRPC6 in breast cancer remains largely unknown. We c...
Tapeworm infection incidence in rural Japan points to a common environmental source of infection [0.03%]
日本农村带绦虫感染率表明存在共同的环境感染源
Dhammika Leshan Wannigama,Mohan Amarasiri,Phatthranit Phattharapornjaroen et al.
Dhammika Leshan Wannigama et al.
Dibothriocephalus nihonkaiensis is a zoonotic tapeworm transmitted to humans through consumption of raw or undercooked fish or wild meat. Between 2022 and 2023, Yamagata Prefecture reported an increase in cases compared with 2017-2021, when...