Anti-virulence activities of biflavonoids from Mesua ferrea L. flower [0.03%]
托里番石榴花中二氢黄酮类化合物的抗毒力作用研究
Xiaochun Zhang,Rongrong Gao,Yan Liu et al.
Xiaochun Zhang et al.
Based on the anti-virulence activity on Salmonella, the ethyl acetate extract (EAE) of Mesua ferrea flower was investigated for its chemical constituents. Ten purified compounds were identified and assayed for their inhibitory activity agai...
Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model [0.03%]
柚皮素对果糖-链脲佐菌素糖尿病大鼠长期高血糖引起的血管变化的影响
Nurul Hannim Zaidun,Zar Chi Thent Sahema,Abdul Aziz Mardiana et al.
Nurul Hannim Zaidun et al.
Chronic uncontrolled hyperglycaemia leads to increased oxidative stress and lipid peroxidation resulting in vascular complications and accelerates the progression of diabetic atherosclerosis. Though varieties of modern drugs used in the tre...
Sanae A Ishijima,Masataro Hiruma,Kazuhisa Sekimizu et al.
Sanae A Ishijima et al.
The prevalence of tinea pedis (also known as athlete's foot) in Japanese workers as well as contamination of their footwear by pathogenic filamentous fungi were investigated. Health checks by a dermatologist at a factory located in the Kant...
Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans [0.03%]
合成姜黄素衍生物Cur2004-8延长寿命并调节秀丽隐杆线虫的年龄相关生理变化
Bo-Kyoung Kim,Sung-A Kim,Sun-Mi Baek et al.
Bo-Kyoung Kim et al.
Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis...
Comparative Study
Drug discoveries & therapeutics. 2019;13(4):198-206. DOI:10.5582/ddt.2019.01057 2019
Repositioning of an anti-depressant drug, agomelatine as therapy for brain injury induced by craniotomy [0.03%]
脑外科开颅手术引起的脑损伤的治疗中抗抑郁药物阿戈美拉汀的重新定位研究
Krishna A Lad,Anurag Maheshwari,Bhagawati Saxena
Krishna A Lad
Traumatic brain injury (TBI) leads to the disruption of blood-brain barrier integrity and therefore results in increased brain water content (brain edema). Brain edema is a significant factor for increased intracranial pressure (ICP), which...
Utility of an adverse drug event database based on the narrative accounts of patients with breast cancer [0.03%]
基于乳腺癌患者叙述的不良事件数据库的价值
Kei Kikuchi,Akiko Miki,Hiroki Satoh et al.
Kei Kikuchi et al.
Patient narratives of adverse drug events (ADEs) often differ from the symptoms listed on the package inserts of pharmaceutical products using common ADE terminology and could be a source of great comfort to patients with the same disease. ...
Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment [0.03%]
新型隐球菌在宿主环境中致病信号转导途径的诱导
Yasuhiko Matsumoto,Saki Azami,Haruka Shiga et al.
Yasuhiko Matsumoto et al.
Cryptococcus neoformans, a human pathogenic fungus, infects immunocompromised humans and causes serious diseases such as cerebral meningitis. C. neoformans controls the expression of virulence factors in response to the host environment via...
Haruka Kuriyama,Ikko Kajihara,Hisashi Kanemaru et al.
Haruka Kuriyama et al.
This is the first case of an angiosarcoma patient with brain abscess, and it might be responsible for skin defect and cranial bone necrosis by surgical excision and radiation. Our patient was treated with 10 courses of triweekly paclitaxel ...
Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after thalamic hemorrhage: A case report [0.03%]
曲唑酮治疗丘脑出血后阵发性交感神经兴奋状态的疗效：1例报告
Yusuke Morinaga,Kouhei Nii,Kimiya Sakamoto et al.
Yusuke Morinaga et al.
Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH t...
A novel highly concentrated enteral nutrition formula, EN-P05, shows nutritional effectiveness comparable to the approved OSN-001 in gastrostomized rats [0.03%]
一种新型高浓态肠内营养配方EN-P05在胃造口大鼠中的营养效果与获批的OSN-001类似
Eiji Kasumi,Yoshie Kuzumaki,Megumi Sadakata et al.
Eiji Kasumi et al.
Enteral nutrition is beneficial support administered as oral supplements or via tube feeding for patients with long-term inability to meet nutritional requirements orally. However, because of the high volumes administered, vomiting and gast...
Comparative Study
Drug discoveries & therapeutics. 2019;13(3):157-163. DOI:10.5582/ddt.2019.01041 2019