Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer [0.03%]
具有定向附着于Caco-2单层性能的Janus微球的制备及其用于增强肠药物递送性能的研究
Akihiro Matsumoto,Chie Watanabe,Masahiro Murakami
Akihiro Matsumoto
Conventional oral preparations generally release incorporated drugs omnidirectionally, including into the lumen, leading to a low bioavailability of drugs that are unstable in the gastrointestinal tract. Here, we designed Janus microspheres...
Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has anti-motility and anti-biofilm activity against enteropathogenic Escherichia coli [0.03%]
悬钩子忍冬亚种果实提取物对致病性大肠杆菌具有抗运动和抗生物被膜作用
Masaaki Minami,Hiroshi Takase,Mineo Nakamura et al.
Masaaki Minami et al.
Foodborne diseases have become a worldwide problem that threatens public health and welfare. Enteropathogenic Escherichia coli (EPEC) is one of major pathogens of moderate to severe diarrhea. The increased prevalence of EPEC strains that pr...
Safflower seed extract synergizes the therapeutic effect of cisplatin and reduces cisplatin-induced nephrotoxicity in human colorectal carcinoma RKO cells and RKO-transplanted mice [0.03%]
丹参素增敏顺铂并减少顺铂肾毒性的体内及体外研究
Chan Hum Park,Min Jo Kim,Chang Yeol Yang et al.
Chan Hum Park et al.
Safflower seed is effective against oxidative stress, mediating the activation of the apoptotic signaling pathway in the renal tissues of cisplatin-treated mice. The anticancer activity of safflower in various cancer cell lines has also bee...
Investigation of efficacy and safety of low-dose sodium glucose transporter 2 inhibitors and differences between two agents, canagliflozin and ipragliflozin, in patients with type 2 diabetes mellitus [0.03%]
低剂量钠-葡萄糖协同转运蛋白2抑制剂的疗效和安全性研究及其两种药物坎格列净与伊格列净之间的差异性研究(2型糖尿病患者)
Kaoru Sugimoto,Ichiro Abe,Midori Minezaki et al.
Kaoru Sugimoto et al.
Sodium glucose transporter 2 inhibitors (SGLT2is), new antidiabetic agents, were reported to improve not only glycemic parameters but also metabolic and circulatory parameters. Whereas, several adverse events caused by SGLT2is were also rep...
Comparative Study
Drug discoveries & therapeutics. 2019;13(6):322-327. DOI:10.5582/ddt.2019.01085 2019
Inhibitions of human parainfluenza virus type 2 replication by ribavirin and mycophenolate mofetil are restored by guanosine and S-(4-nitrobenzyl)-6-thioinosine [0.03%]
利巴韦林和霉酚酸莫特抑制人副流感病毒第二型复制的作用被鸟苷和S-（4-硝基苯甲基）-6硫鸟嘌呤核苷所恢复
Jun Uematsu,Kae Sakai-Sugino,Sahoko Kihira-Nakanishi et al.
Jun Uematsu et al.
The antiviral activities of a nucleoside analog antiviral drug (ribavirin) and a non-nucleoside drug (mycophenolate mofetil) against human parainfluenza virus type 2 (hPIV-2) were investigated, and the restoration of the inhibition by guano...
Gene disruption of ribosomal protein L5 (RPL5) decreased the sensitivity of CHO-K1 cells to uncoupler carbonylcyanide-3-chlorophenylhydrazone [0.03%]
核糖体蛋白L5(RPL5)基因失活降低CHO-K1细胞对解偶联剂氯化苯腙(CCP)的敏感性
Makoto Araki,Takuya Ishibashi,Masahiro Munesue et al.
Makoto Araki et al.
Protonophoric uncoupler carbonylcyanide-3-chlorophenylhydrazone (CCCP) decreases the proton motive force (ΔP) of the mitochondrial inner membrane and results in inhibition of oxidative phosphorylation. In this study, a CCCP-resistant clone...
Different activities of antitumor immunomodulators to induce neutrophil adherence response [0.03%]
抗肿瘤免疫调节剂诱导中性粒细胞黏附反应的多样性研究
Motoharu Tanaka,Shigeru Abe
Motoharu Tanaka
Functions of neutrophils, major participant in host defense mechanisms, are known to be regulated by various types of immunomodulators. Capacity of immunomodulators which are reported to show antitumor effect in vivo to induce neutorophil a...
A case of overlap syndrome (scleroderma and polymyositis) associated with the development of sudden chest pain due to myocardial damage [0.03%]
以突发性胸痛、心肌损伤起病的重叠综合征(系统性硬化症和多发性肌炎)1例
Akira Kaneko,Ikko Kajihara,Azusa Miyashita et al.
Akira Kaneko et al.
Myocardial injury with systemic sclerosis (SSc) causes pericarditis and arrhythmia, and polymyositis-induced muscle inflammation causes myocarditis. We report a rare case of overlap syndrome (SSc and polymyositis) who presented with sudden ...
Characteristics of subcutaneous tissues at the site of insertion of peripheral infusion in patients undergoing paclitaxel and carboplatin chemotherapy [0.03%]
接受帕利昔尤单抗和卡铂化疗患者的外周输液插入部位皮下组织特征
Ryoko Murayama,Maiko Oya,Mari Abe-Doi et al.
Ryoko Murayama et al.
Paclitaxel, a taxane, is frequently administered intravenously as an anticancer agent. When a peripheral intravenous catheter is used for paclitaxel infusion, clinical nurses often observe signs such as slight swelling at the catheter place...
Observational Study
Drug discoveries & therapeutics. 2019;13(5):288-293. DOI:10.5582/ddt.2019.01064
Catheter tips are a possible resource for biological study on catheter failure [0.03%]
导管尖端可能是一种研究导管故障的生物资源
Toshiaki Takahashi,Takeo Minematsu,Ryoko Murayama et al.
Toshiaki Takahashi et al.
Few studies have investigated the molecular mechanisms of catheter failure (CF). Herein, we performed histological and molecular biological analyses of the catheter tip to demonstrate its potential as a resource for biological investigation...
Observational Study
Drug discoveries & therapeutics. 2019;13(5):280-287. DOI:10.5582/ddt.2019.01073