Re-tasking the use of pre-existing medications and potential therapeutic options for coronavirus disease (COVID-19): systematic review of clinical studies [0.03%]
新冠肺炎(COVID-19)药物再利用和潜在治疗选择的系统评价：临床试验部分
Bushra Hassan Marouf,Kawa Dizaye
Bushra Hassan Marouf
With the emergence of coronavirus disease 2019 (COVID-19) in late December 2019, many clinical studies on a group of the pre-existing medications have been conducted to treat this disease. The purpose of this review was to compile the clini...
Increase of lymphocytes and eosinophils, and decrease of neutrophils at an early stage of anti-PD-1 antibody treatment is a favorable sign for advanced malignant melanoma [0.03%]
抗PD-1抗体治疗黑色素瘤早期淋病细胞和嗜酸性粒细胞增加及中性粒细胞减少提示预后较好
Hiroyuki Ohashi,Sora Takeuchi,Tomomitsu Miyagaki et al.
Hiroyuki Ohashi et al.
The advent of immune checkpoint inhibitors such as anti-PD-1 antibodies had a striking impact on the treatment for advanced malignant melanoma. However, less than half of the patients benefited from those antibodies, and biomarkers that cou...
Targeting lymphocyte Kv1.3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy? [0.03%]
针对淋巴细胞Kv1.3通道抑制严重COVID-19患者细胞因子风暴的潜在治疗策略：它可以成为一种新疗法吗？
Itsuro Kazama
Itsuro Kazama
In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K+-channels (Kv1.3) in leukocytes is responsib...
Can mesenchymal stem cell therapy be the interim management of COVID-19? [0.03%]
间充质干细胞治疗可否用于新冠肺炎的过渡期治疗？
Chitra Bamba,Surinder P Singh,Sangeeta Choudhury
Chitra Bamba
COVID-19 pandemic has accounted for ~ 4.3 million confirmed cases and ~ 292,000 deaths (till 12th May, 2020) across the globe since its outbreak. Several anti-viral drugs such as RNA dependent RNA polymerase inhibitors (remdesivir, favipira...
Prospects for development of group purchasing organizations (GPOs) in China within the context of national centralized drug procurement [0.03%]
国家集中带量采购背景下中国集团采购组织(GPO)的发展前景分析研究
Minxing Chen,Lixuan Cong,Jiangjiang He et al.
Minxing Chen et al.
Healthcare group purchasing organizations (GPOs) are considered to play an integral role in the healthcare supply chain by keeping prices low and helping all members of the healthcare system achieve their objectives. China has been explorin...
Visual improvement in a patient with paracentral acute middle maculopathy treated with prostaglandin E1 [0.03%]
治疗前列腺素E1后中心旁急性中部视网膜病变患者视力改善一例报告
Robert Davis Jr Steigerwalt,Marcella Nebbioso
Robert Davis Jr Steigerwalt
The authors present the use of prostaglandin E1 (PGE1) for the treatment of an acute paracentral acute middle maculopathy (PAMM). A 78-year-old white female was seen with a sudden loss of vision in her left eye (OS) to 20/200 noted upon awa...
Change of serum cytokine profiles by propranolol treatment in patients with infantile hemangioma [0.03%]
普奈洛尔治疗婴儿血管瘤患者血清细胞因子谱变化研究
Sayaka Tani,Kayo Kunimoto,Yutaka Inaba et al.
Sayaka Tani et al.
Infantile hemangioma is a benign cutaneous tumor, which sometimes rapidly enlarges, causes cosmetic problem, destroys normal tissue, and possibly threatens life. Dye lasers, steroid administration, and watchful waiting had been the treatmen...
Clinical Trial
Drug discoveries & therapeutics. 2020;14(2):89-92. DOI:10.5582/ddt.2020.03014 2020
Therapeutic effect of Chinese prescription Kangen-karyu in patients with diabetic nephropathy [0.03%]
糖尿病肾病患者接受康纳肾略方治疗的临床疗效分析
Chan Hum Park,Kazuyuki Hiratani,Toshiki Natazuka et al.
Chan Hum Park et al.
Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. A number of new therapies have been developed based on the pathogenic factors of diabetic nephropathy such as intensive glycemic control, precise hypertension c...
Clinical Trial
Drug discoveries & therapeutics. 2020;14(2):84-88. DOI:10.5582/ddt.2020.01013 2020
Effects of the combined administration of risedronate and menatetrenone on bone loss induced by tacrolimus in rats [0.03%]
雷奈酸锶与维生素K2合用对他克莫司致大鼠骨丢失的影响
Junkichi Kanda,Megumi Furukawa,Nobuo Izumo et al.
Junkichi Kanda et al.
Tacrolimus, a calcineurin inhibitor, affects bone metabolism and increases the risk of fracture due to marked bone loss. Bisphosphonates increase the bone mineral density (BMD) in osteoporosis patients. Menatetrenone has less positive effec...
Ziyi Li,Xiaojie Wang,Donglin Cao et al.
Ziyi Li et al.
The outbreak of SARS-CoV-2 rapidly spread across China and worldwide. Remdesivir had been proposed as a promising option for treating coronavirus disease 2019 (COVID-19). We provided a rapid review to critically assess the potential anti-co...