Equivalence in the modernization of Chinese medicine: A multi-dimensional analysis of active components, processing methods, and clinical outcomes in formula granules [0.03%]
中药现代化等效性研究：从活性成分、炮制方法及临床疗效多角度探讨颗粒剂的等效性问题
Bo Xie,Xi Qu,Huijing Shi et al.
Bo Xie et al.
The feasibility of substituting traditional decoction pieces with Chinese herbal formula granules fundamentally hinges on the equivalence of their active components. Formula granules face complex compositional changes during manufacturing: ...
Three-dimensional imaging provides reliable size measurement of skin lesions associated with vascular anomalies: A comparison with two-dimensional photography [0.03%]
三维成像技术能够可靠测量血管病变相关皮肤损害的大小：与二维摄影对比研究
Kana Sakai,Kayo Kunimoto,Yuna Noda et al.
Kana Sakai et al.
Three-dimensional (3D) imaging techniques enable accurate quantitative size measurement, and have been used to evaluate treatment effects on skin lesions such as ulcers, burns, and skin laxity. This study aimed to establish and validate a 3...
Analgesic effects of Goreisan in patients with glossodynia: A preliminary exploratory study [0.03%]
葛氏愈龋方治疗舌痛症患者的止痛效果：初步探索性研究
Takao Ayuse,Shuntaro Sato,Ichiro Okayasu et al.
Takao Ayuse et al.
Glossodynia-related pain refers to persistent, chronic pain occurring on the oral mucosal surface. Various medications are prescribed depending on symptom profiles and have demonstrated therapeutic benefits; however, these agents are often ...
Potworm (Enchytraeus japonensis) as a potential platform for drug screening in regenerative medicine [0.03%]
Japanese斑腿槽蚓(Enchytraeus japonensis)作为再生医学中药物筛选的潜在平台
Toshiyuki Fujita,Shinji Yamaguchi
Toshiyuki Fujita
Regenerative medicine holds substantial promise for restoring the function of damaged or lost organs and tissues. However, the development of effective small-molecule drugs in this field has been limited, partially owing to the lack of suit...
Development of ginger extract-loaded self-nanoemulsifying drug delivery system for enhanced solubility of ginger extract [0.03%]
一种新型生姜提取物自微乳化药物传输系统（SMEDDS）的开发用于提高生姜提取物溶解度
Maung Maung Than,Chuda Chittasupho,Songwut Yotsawimonwat et al.
Maung Maung Than et al.
The well-known medicinal plant ginger (Zingiber officinale Roscoe) has numerous health benefits, but its key bioactive compound, 6-gingerol, suffers from poor water solubility and stability. This study aimed to enhance the oral delivery of ...
Xuefu Zhuyu Capsule alleviates depression in post-stroke depression model rats via modulation of the gut microbiota-gut-brain axis [0.03%]
雪上一枝蒿胶囊通过调节肠菌-肠-脑轴改善卒中后抑郁模型大鼠的抑郁样行为
Bowen Jin,Yuqian Wang,Zhaowei Zhang et al.
Bowen Jin et al.
Xuefu Zhuyu Capsule (XFZY) demonstrated potential in alleviating post-stroke depression (PSD), a condition whose underlying mechanisms may involve the gut-brain axis. This study aimed to explore the therapeutic effects of XFZY on PSD and it...
Microneedle patch-enhanced palatal anesthesia with benzocaine: Efficacy and safety in a randomized double-blind crossover trial [0.03%]
微针贴剂增效式苯佐卡因腭部麻醉法：随机双盲交叉试验评估其疗效和安全性
Kensuke Kiriishi,Terumi Ayuse,Naomi Tanoue et al.
Kensuke Kiriishi et al.
Needle-insertion pain during dental local anesthesia remains one of the strongest triggers of dental anxiety. Conventional topical anesthetics show limited penetration through the thick palatal mucosa and often provide insufficient suppress...
A blended learning program sustains pharmacists' oral health support competency for 15 months: A longitudinal study [0.03%]
一项混合学习项目在15个月内持续提高药师口腔健康支持能力：一项纵向研究
Naoko Hayashi,Tomoyuki Goto,Yasuo Shiga et al.
Naoko Hayashi et al.
The importance of oral health has gained increasing recognition in the recent years owing to its association with numerous systemic diseases such as diabetes and cardiovascular disease. Dental checkups are crucial for maintaining and promot...
Comparison of salivary Mucin 5B (MUC5B) secretion between heat-not-burn tobacco users and non-smokers [0.03%]
与非吸烟者相比加热不燃烧烟草使用者的分泌性黏蛋白5B(MUC5B)差异分析
Yukihiro Mori,Mamoru Tanaka,Hana Kozai et al.
Yukihiro Mori et al.
The use of heat-not-burn (HNB) tobacco is rapidly increasing, particularly in Japan; however, its health effects, especially on innate immunity in the oral mucosa, remain unclear. This cross-sectional study aimed to compare the secretion le...
Protein persulfidation: The missing link in Alzheimer's disease defense mechanisms [0.03%]
蛋白质聚硫化：阿尔茨海默病防御机制的缺失环节
Ya-Nan Ma,Xiaoxi Huang,Ying Xia et al.
Ya-Nan Ma et al.
Despite decades of research dominated by the amyloid-beta hypothesis, clinical treatment of Alzheimer's disease (AD) has yet to achieve a decisive breakthrough. This editorial advances an alternative pathological paradigm: the collapse of e...