Chemotherapy combined targeted therapy has a potential benefit on the survival of advanced intrahepatic cholangiocarcinoma [0.03%]
化疗联合靶向治疗可能改善晚期肝内胆管癌患者的生存率
Jian Yang,Tengqian Tang,Rui Liao et al.
Jian Yang et al.
The treatment strategies and outcomes for advanced intrahepatic cholangiocarcinoma (ICC) are restricted. The treatment modalities and effectiveness of local interventional chemotherapy and systemic chemotherapy remain indeterminate. The obj...
Efficacy and safety of filgotinib versus tocilizumab in active rheumatoid arthritis: A randomized, open-label, multicenter study with clinical and musculoskeletal ultrasound evaluation (TRANSFORM study) [0.03%]
.filgotinib与托珠单抗治疗活动性类风湿关节炎疗效和安全性的随机、开放标签、多中心研究（包括临床及肌肉骨骼超声评估）（TRANSFORM研究）
Toshimasa Shimizu,Shin-Ya Kawashiri,Tomohiro Koga et al.
Toshimasa Shimizu et al.
Janus kinase (JAK) and interleukin-6 (IL-6) inhibitors are therapeutic options for patients with rheumatoid arthritis (RA) with inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs); however, no rand...
Modern research on formulated granules of traditional Chinese medicines and Japanese Kampo medicines: A narrative review [0.03%]
传统中药和日本汉方制剂颗粒的研究进展：叙述性回顾
Wenyuan Li
Wenyuan Li
The modernization of traditional medicine follows diverse pathways. This paper aims to provide a narrative review of the manufacturing processes, research on active ingredients, and models for the clinical use of formulated granules of trad...
Classical traditional Chinese medicine formulas for inflammatory bowel disease: therapeutic evidence and mechanistic insights [0.03%]
经典中医方药治疗炎症性肠病的证据和机制研究进展
Lichao Yang,Zhixian Jiang,Qi Sun et al.
Lichao Yang et al.
Inflammatory bowel disease (IBD) is a digestive system disorder characterized by chronic recurrent inflammation, primarily including ulcerative colitis (UC) and Crohn's disease (CD). Although modern precision medicine therapies, represented...
Artificial intelligence (AI)-assisted ultrasound in clinical trials: Endpoint automation, decentralized monitoring, and regulatory readiness [0.03%]
临床试验中辅助超声的人工智能（AI）：终点自动化、分散式监测和监管准备状态
Kenji Karako,Jianjun Gao
Kenji Karako
Ultrasound is among the most widely used imaging modalities in clinical trials, and yet its dependence on operator skill and equipment settings has historically limited the reproducibility of ultrasound-based endpoints in multi-center studi...
Amelioration of gastrointestinal motility and gut dysbiosis by acupoint application of Tongfu Powder to loperamide-induced constipation in mice [0.03%]
通腹散穴位敷贴改善洛哌丁胺致小鼠便秘的胃肠运动及肠道菌群失调作用研究
Ke Wang,Pingping Cai,Lin Zhao et al.
Ke Wang et al.
Chronic constipation is one of the most common gastrointestinal disorders worldwide. It has an impact on daily life and poses a considerable economic burden. Tongfu Powder originated from the Xiaochengqi Decoction with the intent of promoti...
Trends in the prescription of constipation medications in Japan (fiscal years 2019-2023): A nationwide baseline study prior to the 2023 clinical guidelines [0.03%]
日本2019至2023财年便秘药物处方趋势（2023年临床指南前的全国基线研究）
Hiroyuki Tanaka,Toshihiro Ishii
Hiroyuki Tanaka
Constipation is a common gastrointestinal disorder that markedly affects health and quality of life. In Japan, magnesium-based and contact laxatives have long been widely prescribed. Since the launch of lubiprostone in November 2012, severa...
Cytoderm metabolic-labeling SCMLP-TB for pulmonary tuberculosis diagnosis: a preliminary diagnostic accuracy study [0.03%]
细胞皮肤代谢标记SCMLP-TB用于肺结核诊断的准确性研究：一项初步研究
Guangyan Liang,Guiqin Dai,Xiaorong Hu et al.
Guangyan Liang et al.
Tuberculosis (TB) remains a significant global health issue. Early diagnosis is crucial, yet current diagnostic technologies are limited by suboptimal sensitivity. Thus, we developed a novel tuberculosis metabolic labeling probe (single cel...
Hypoalbuminemia and reduced sputum microbiome diversity associated with antibiotic treatment failure in nursing and healthcare-associated pneumonia [0.03%]
与护理和保健相关性肺炎抗生素治疗失败相关的低白蛋白血症和痰液微生物组多样性降低
Naoki Hosogaya,Shoichi Fukui,Takahiro Takazono et al.
Naoki Hosogaya et al.
Nursing and healthcare-associated pneumonia (NHCAP) pose significant challenges in older populations, yet factors predicting antibiotic treatment failure remain elusive. This exploratory secondary analysis of a multicenter phase IV trial ai...
Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease [0.03%]
Janus激酶抑制剂和白细胞介素-6抑制剂对病因性多中心Castleman病患者血清细胞因子/趋化因子的影响
Shoichi Fukui,Remi Sumiyoshi,Tomohiro Koga et al.
Shoichi Fukui et al.
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disease characterized by systemic inflammation. Although IL-6 receptor blockade with tocilizumab is an established treatment, Janus kinase (JAK) inhibition may o...