Rethinking the use of direct oral anticoagulants for secondary thromboprophylaxis in patients with thrombotic antiphospholipid syndrome [0.03%]
抗磷脂综合征患者二级血栓预防中直接口服抗凝剂的使用反思
Anabel Franco-Moreno,Aida Izquierdo-Martínez,Cristina Ancos-Aracil
Anabel Franco-Moreno
Patients with thrombotic antiphospholipid syndrome (APS) are at high risk for recurrent thrombosis, and indefinite anticoagulation is recommended. Patients with APS merit indefinite anticoagulation, and vitamin K antagonists (VKAs) have his...
Prevalence of pregnancy- and lactation-associated osteoporosis in the postpartum period: A systematic review and meta-analysis [0.03%]
产后妊娠和哺乳期骨质疏松症的患病率：系统回顾和荟萃分析
Maiko Fukushima,Maiko Kawajiri,Mikako Yoshida et al.
Maiko Fukushima et al.
This systematic review and meta-analysis aimed to estimate the prevalence of pregnancy- and lactation-associated osteoporosis in postpartum women within 1 year of delivery. We searched MEDLINE via PubMed and Igaku Chuo Zasshi for articles p...
Development of a silkworm infection model for evaluating the virulence of Mycobacterium intracellulare subspecies estimated using phylogenetic tree analysis based on core gene data [0.03%]
基于核心基因数据的系统发育树分析估算的鸟分支胞内分枝杆菌亚种丝瓜感染模型的建立及毒力评价
Yasuhiko Matsumoto,Hanako Fukano,Takeshi Komine et al.
Yasuhiko Matsumoto et al.
Non-tuberculous mycobacteria (NTM) cause skin infections, respiratory diseases, and disseminated infections. Mycobacterium avium and Mycobacterium intracellulare, which are slow grown Mycobacterium, are main agents of those NTM diseases. A ...
The BDNF-ERK/MAPK axis reduces phosphatase and actin regulator1, 2 and 3 (PHACTR1, 2 and 3) mRNA expressions in cortical neurons [0.03%]
BDNF-ERK/MAPK轴降低皮质神经元中磷酸酶和肌动蛋白调节因子1、2和3(PHACTR1、2和3)mRNA的表达
Daisuke Ihara,Ryotaro Oishi,Shiho Kasahara et al.
Daisuke Ihara et al.
Actin rearrangement and phosphorylation-dephosphorylation in the nervous system contribute to plastic alteration of neuronal structure and function. Phosphatase and actin regulator (PHACTR) family members are actin- and protein phosphatase ...
Determination of anamorelin concentration in human plasma using a simple high-performance liquid chromatography-ultraviolet detection method [0.03%]
一种简单的人血浆中阿那莫林浓度测定的高效液相色谱-紫外检测方法
Takeo Yasu,Nanami Iwatuki,Yoshito Gando et al.
Takeo Yasu et al.
Anamorelin, a non-peptide ghrelin analog and growth hormone secretagogue, is a novel oral drug used to treat cancer cachexia. Patients with cancer cachexia frequently use several drugs and anamorelin is a substrate of cytochrome P450 (CYP) ...
Evaluation of in vivo pharmacokinetic study of the anti-cancer drug imatinib using silkworms as an animal model [0.03%]
利用蚕作为动物模型评估抗肿瘤药物甲磺酸伊马替尼的体内药代动力学性质
Takeo Yasu,Yasuhiko Matsumoto,Takashi Sugita
Takeo Yasu
Imatinib is an oral molecular targeted therapy that acts as a tyrosine kinase inhibitor. Silkworms present a promising experimental model for elucidating the pharmacokinetic and toxicity profiles of various compounds. This study aimed to es...
Patient awareness and practices regarding antimicrobial use and drug resistance [0.03%]
患者关于抗菌药物使用和耐药问题的意识及行为
Atsushi Ishimura,Mayumi Tomizaki,Yoshitsune Yamato
Atsushi Ishimura
Drug-resistant bacterial infections have become a substantial problem in various communities. Appropriate antimicrobial use is required because reducing antimicrobial use could reduce the number of resistant bacteria. The inappropriate use ...
Tailored to fit: China optimizes policies and regulations regarding drug registration and review to promote innovation in traditional Chinese medicine [0.03%]
量身定制：中国优化中药注册管理政策及法规以促进创新中医药发展
Daoran Lu,Fangzhou Dou,Fanghua Qi et al.
Daoran Lu et al.
The classification system for drug registration and the review and approval process influence the innovation and development of pharmaceuticals. China's previous classification standards for registration of traditional Chinese medicines (TC...
Duzhong Fang ameliorates cognitive impairment of Parkinsonian mice by suppressing neuronal apoptotic pathway [0.03%]
杜仲防通过抑制神经元凋亡通路改善帕金森模型小鼠认知障碍作用研究
Qian Shen,Ruiting Liu,Yu Wang et al.
Qian Shen et al.
Parkinson's disease (PD) is a complex multisystem neurodegenerative disease, and cognitive impairment is a common symptom in the trajectory of PD. Duzhong Fang (DZF) consists of Eucommia ulmoides, Dendrobium, Rehmanniae Radix, and Dried Gin...
The S-Nitrosylation of Septin2 (SNO-Septin2) axis: A novel potential therapeutic target for treating aneurysms and dissection [0.03%]
Septin2(SNO-Septin2)轴：治疗动脉瘤和血管夹层的潜在新靶点
Ying Zhang,Hongtao Qu,Chuanhua Li et al.
Ying Zhang et al.
Aortic aneurysm and aortic dissection (AAD) are severe life-threatening cardiovascular disorders for which no approved pharmaceutical therapies are currently available. Protein S-nitrosylation (SNO) is a typical redox-dependent posttranslat...