Notch signaling pathway plays a critical role in chemotherapeutic drug-induced vestibular injury [0.03%]
诺托信号途径在化疗药物所致前庭损害中起关键作用
Wen Jiang,Jie Yu,Maorong Cao et al.
Wen Jiang et al.
The vestibule of the inner ear is susceptible to certain chemotherapeutic agents in clinical practice. Therefore, it is of great significance to discover molecular pathways and targets that can protect the vestibule from chemotherapeutic dr...
A well-matched marriage of immunotherapy and radiofrequency ablation to reduce the relapse and progression of hepatocellular carcinoma [0.03%]
免疫疗法与射频消融联合用于降低肝细胞癌复发和进展的风险
Rui Liao,Peipei Song,Yuxin Duan et al.
Rui Liao et al.
Hepatocellular carcinoma (HCC) remains a health challenge with increasing incidence worldwide. Radiofrequency ablation (RFA) is a potentially curative option for patients with early-stage HCC. However, the high rate of tumor recurrence limi...
An average of nearly 200,000 new infections per day over a six-week period: What is the impact of such a severe COVID-19 pandemic on the healthcare system in Japan? [0.03%]
每日平均新增近20万例，历时六周：新冠肺炎疫情严重程度对日本医疗体系的影响几何？
Kenji Karako,Peipei Song,Yu Chen et al.
Kenji Karako et al.
During a six-week period from July 20 to August 31, 2022, Japan experienced its highest level of COVID-19 infection ever, with an average of nearly 200,000 new infections per day nationwide. Cases requiring inpatient care peaked at 1,993,06...
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information [0.03%]
酮酸途径能成为帕金森病的下一代治疗靶点吗？最新研究信息更新
Wei Qin,Yirong Shi,Weimei Chen et al.
Wei Qin et al.
By far, no revolutionary breakthrough in the treatment of Parkinson's disease (PD) was found. It is indeed a knotty problem to select a satisfactory strategy for treating some patients with advanced stage PD. Development of novel therapeuti...
Development of an in vitro insulin resistance dissociated model of hepatic steatosis by co-culture system [0.03%]
一种体外胰岛素抵抗分离的肝脂肪变性模型的开发：共培养系统
Jiangwei Xiao,Xiang Li,Zongbao Zhou et al.
Jiangwei Xiao et al.
The evidence shows that there is an associated relationship between hepatosteatosis and insulin resistance. While some existing genetic induction animal and patient models challenge this relationship, indicating that hepatosteatosis is diss...
Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma via the miRNA-4474-3P-ALOX-15 and EMT axes [0.03%]
肝星状细胞源外泌体携带的环状circWDR25通过miR-4474-3P-ALOX-15及EMT轴促进肝癌进展
Lei Liu,Rui Liao,Zhongjun Wu et al.
Lei Liu et al.
Recently, the emerging role of circular RNAs (circRNAs) in tumor development and progression has been a topic of great interest. Nevertheless, the effects of hepatic stellate cell (HSC)-derived exosomes in hepatocellular carcinoma (HCC) rem...
Xiaoning Liu,Zheng Zhu,Qiqi Miao et al.
Xiaoning Liu et al.
Since the end of June 2022, there has been a dramatic increase in the number of monkeypox cases worldwide. Given the potential spread of this epidemic, WHO has declared the monkeypox epidemic a global public health emergency. In the face of...
Heparin therapy in COVID-19: Call for randomized controlled trials (RCTs) [0.03%]
呼吁开展随机对照试验(RCT)，探讨COVID-19的肝素治疗
Tingting Fang,Xianyang Pan,Ju Huang et al.
Tingting Fang et al.
Coronavirus disease 2019 (COVID-19) is associated with increases in abnormal coagulation, and particularly D-dimer (D-D) levels. Heparin therapy has been recommended as pharmacologic thromboprophylaxis in patients hospitalized with COVID-19...
Fang Zhao,Yun He,Hongzhou Lu
Fang Zhao
Two cases of the deadly Marburgvirus were reported in Ghana, which might be a new global virus alert following COVID-19 and novel monkeypox. Thus far, there is no vaccine or treatment for Marburg virus disease, which is a disease with a mor...
Ting Li,Tetsuya Asakawa,Hui Liu et al.
Ting Li et al.
COVID-19 has been a topic of interest since a pandemic struck in 2019. The morbidity of influenza tended to decrease due to the measures to prevent COVID-19. Indeed, influenza seems to be "ignored" in this era of COVID-19. However, influenz...