Neurotropin alleviates Alzheimer's disease pathology by inhibiting FUS-mediated Calhm2 transcription, blocking the Calhm2/EFhd2 interaction, to improve mitochondrial dysfunction-associated microglia polarization [0.03%]
神经生长因子通过抑制FUS介导的Calhm2转录,阻断Calhm2/EFhd2相互作用改善线粒体功能异常相关的小胶质细胞极化以缓解阿尔茨海默病病理表型
Yuanlu Huang,Fusheng Wei,Xiaoe Cheng et al.
Yuanlu Huang et al.
Neurotropin, a non-protein extract widely used for the treatment of neuropathic pain, has recently been reported to protect against ischemic brain injury, enhance remyelination in demyelinating diseases, and ameliorate neuroinflammation and...
Exploring the pathway of a social network in promoting the individual performance of core members of social organizations caring for the elderly: A moderated mediation model of social support and self-efficacy [0.03%]
社会支持和自我效能的调节中介模型:探究社交网络促进老年关怀社会组织核心成员个体绩效的路径效应
Xin Zheng,Sanyuan Hao,Ziwen Xu et al.
Xin Zheng et al.
The high performance of core members of social organizations (SOs) caring for the elderly can enhance the quality of management and services, thereby improving the life satisfaction of older adults residing there. However, the factors influ...
Human resources in long-term care for older adults in China: Challenges amid population aging [0.03%]
中国老年人长期护理人力资源的挑战:人口老龄化的背景下
Nadida Aximu,Bahegu Yimingniyazi,Dapeng Lin et al.
Nadida Aximu et al.
Against the backdrop of accelerating global population aging, China is undergoing significant demographic shifts. Its population aged 60 and above has reached 264 million, projected to account for 40% of the total population by the mid-21st...
Therapeutic strategies in traditional Chinese medicine for premature ovarian failure: Modulation of oxidative stress and autophagy-apoptosis via the AMPK/mTOR pathway [0.03%]
中医治疗早发性卵巢衰竭的策略研究:AMPK/mTOR信号通路调控氧化应激及自噬-凋亡的作用机制
Wenli Cao,Siling Liu,Leifang Zhang et al.
Wenli Cao et al.
Premature ovarian failure (POF), also referred to as premature ovarian insufficiency (POI), is a multifactorial reproductive endocrine disorder characterized by amenorrhea, infertility, hypoestrogenism, and elevated gonadotropin levels befo...
Chinese expert consensus on the combined use of antiviral drugs for novel coronavirus infection [0.03%]
新型冠状病毒肺炎抗病毒药物联合应用专家共识
Guangbin Chen,Jing Yuan,Yue Wei et al.
Guangbin Chen et al.
The persistent mutation of the novel coronavirus (SARS-CoV-2) not only remains a threat to human health but also continues to challenge existing antiviral therapeutic strategies. In current clinical practice, the resistance of novel coronav...
Expert consensus on combination antiviral therapy for high-risk COVID-19 patients: A timely call to action [0.03%]
高风险新冠病毒感染患者抗病毒治疗专家共识及时呼吁
Guangbin Chen,Hongzhou Lu
Guangbin Chen
On May 5, 2023, the WHO declared that the COVID-19 pandemic no longer constitutes a public health emergency of international concern (PHEIC), but SARS-CoV-2 continues to spread and evolve on a global scale. The WHO reported that COVID-19 st...
APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications [0.03%]
载脂蛋白ε4通过重编程小胶质细胞脂质代谢促进阿尔茨海默病的发病机制及治疗策略
Jiajie Chen,Shuoyan Zhao,Yingying Zhou et al.
Jiajie Chen et al.
The apolipoprotein E ε4 (APOE ε4) allele, the strongest genetic risk factor for late-onset Alzheimer's disease (AD), induces cell-type-specific disturbances in brain lipid metabolism. Although impacting astrocytes and neurons, its most pr...
Anatomical study of the caudate lobe of the liver on hepatic casts and the dawn of isolated caudate lobectomy [0.03%]
肝铸型标本肝尾状叶解剖学研究及孤立性尾状叶切除的起源
Yoshihiro Sakamoto,Masaharu Kogure,Satoru Seo et al.
Yoshihiro Sakamoto et al.
Surgical resection of the caudate lobe of the liver remains the final hurdle for liver surgeons, not only in open hepatectomy but also in recent minimally invasive hepatectomy. In the dawn of liver surgery, Prof. Kumon made hepatic casts an...
Chinese multicenter expert consensus on the diagnosis and treatment of hilar cholangiocarcinoma: 2025 edition [0.03%]
中国肝门部胆管癌诊断和治疗专家共识(2025版)
Sulai Liu,Jinqiong Jiang,Qian Jian et al.
Sulai Liu et al.
Hilar cholangiocarcinoma (hCCA) is a malignant tumor originating from the epithelial cells of the bile ducts, and it is characterized by an aggressive nature, complex surgical management, high mortality, and poor prognosis. Despite recent a...
Chikungunya's global rebound and Asia's growing vulnerability: Implications for integrated vector control and pandemic preparedness [0.03%]
回归与亚洲脆弱性的增加:整合媒介控制和大流行准备的启示
Jing Ni,Zhifang Li,Xiaowei Hu et al.
Jing Ni et al.
Chikungunya fever is a mosquito-borne disease caused by an RNA virus of the Alphavirus genus and is characterized by fever and severe joint pain. The disease is primarily transmitted by Aedes aegypti and Ae. albopictus mosquitoes. Since its...