The dual role of TRPA1 in dextran sulfate sodium (DSS)-induced murine colitis: Suppression alleviates acute inflammation but exacerbates subacute disease [0.03%]
TRPA1在葡聚糖硫酸钠诱导的小鼠结肠炎中的双刃剑作用：TRPA1抑制减轻急性炎症但加重亚急性期疾病症状
Fangzhou Dou,Jing Li,Daoran Lu et al.
Fangzhou Dou et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options. Transient receptor potential ankyrin 1 (TRPA1) has been implicated in inflammation and pain, but its role in UC remains a subject of debate. The...
Hearing impairment in Parkinson's disease models: Possible relation with changes in cochlear efferent fibers [0.03%]
帕金森病模型中的听力损害：耳蜗传出纤维变化的可能关系
Hao Zhao,Shijun Peng,Rui Zhao et al.
Hao Zhao et al.
Hearing impairments, as a prevalent and debilitating non-motor symptom of Parkinson's disease (PD), remain unclear in mechanisms. In this work, we established PD mouse and rat models by using 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MP...
Effect of Yiqi Bushen Shugan Huoxue Decoction on impaired endometrial receptivity associated with ovarian stimulation: A clinical trial, modular pharmacology, molecular docking, and experiment-based study [0.03%]
益气补肾疏肝活血汤对辅助生殖促排卵后子宫内膜容受性下降的影响：临床试验、模块化药理学、分子对接及实验研究
Xinyao Pan,Qing Qi,Jing Wang et al.
Xinyao Pan et al.
Endometrial receptivity plays a critical role in pregnancy, while controlled ovarian hyperstimulation (COH) - widely used for infertile patients - could impair endometrial receptivity and subsequent pregnancy outcomes. This study aims to ex...
Are artificial retinas merely an approach to recover sight, or are they a tool of augmented reality beyond natural eyes in blind people? [0.03%]
仿生视网膜是恢复盲人视力的工具，还是超越自然眼睛的增强现实手段？
Zijia Zhao,Tetsuya Asakawa
Zijia Zhao
Implantable artificial retinas have been a considerable technology to help blind people recover their sight. This topic has attracted increasing attention from both patients and clinicians because of the refractory nature of degenerative re...
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging [0.03%]
炎症衰老轴：生理性和IBD相关性加速的肠道衰老之间的相同和不同的机制
Lichao Yang,Zhixian Jiang,Qi Sun et al.
Lichao Yang et al.
Inflammatory bowel disease (IBD) and physiological gut aging present with overlapping clinical features, including impaired barrier functioning, decreased nutrient absorption, and intestinal frailty. Emerging evidence indicates that even yo...
Research on precision treatment of pancreatic cancer targeted by antibody-drug conjugates [0.03%]
抗体药物偶联物靶向精准治疗胰腺癌的研究
Xinyue Liu,Weishuai Liu,Chao Wu et al.
Xinyue Liu et al.
Pancreatic cancer, and especially pancreatic ductal adenocarcinoma (PDAC), is extremely difficult to treat due to early asymptomatic stage, molecular heterogeneity, and resistance to conventional treatments, with a 5-year survival rate of l...
Transformation of healthcare models and creation of integrated care systems in an aging society: A comparative perspective of the Netherlands, Japan, and China [0.03%]
老龄化社会下的医疗模式转型与整合型卫生体系构建——荷兰、日本和中国的比较视角
Ren Chen,Wei Tang
Ren Chen
Faced with the global challenges of population aging and a surge in dementia cases, healthcare models worldwide are undergoing profound transformation. The Netherlands' "dementia villages" concept simulates living environments, with their a...
Dementia strategies in an aging society: Policies, care, and global insights from the Japanese experience [0.03%]
老龄化社会中的痴呆症战略：来自日本经验的政策、护理和全球见解
Yi Deng,Ya-Nan Ma,Katsuya Yamauchi et al.
Yi Deng et al.
Aging of the population has become a critical challenge globally. The proportion of individuals age 60 years and older is projected to increase from 12% in 2015 to 22% by 2050, representing more than 2.1 billion older adults globally. This ...
Integrative methylation and transcriptomic analysis reveals key genes linking cellular senescence and metabolic reprogramming in colorectal liver metastasis [0.03%]
整合甲基化和转录组分析揭示关键基因连接结直肠癌肝转移中细胞衰老与代谢重编程
Xiaochen Ma,Lu Chen,Chenhe Yi et al.
Xiaochen Ma et al.
Colorectal liver metastasis (CRLM) remains lethal, and the convergence of cellular senescence with metabolic reprogramming via epigenomic rewiring is poorly understood. We integrated genome-wide DNA methylation and RNA-seq data from 10 pair...
Chinese expert consensus on the combined use of antiviral drugs for influenza [0.03%]
中国流感抗病毒药物治疗规范专家共识
Jing Yuan,Haimei Zhang,Rongrong Zou et al.
Jing Yuan et al.
Influenza is an acute respiratory infectious disease caused by influenza viruses, and it poses a serious threat to global public health. High-risk groups include the elderly, infants and young children, pregnant women, and patients with chr...