How do RNA binding proteins trigger liquid-liquid phase separation in human health and diseases? [0.03%]
RNA结合蛋白如何在人类健康和疾病中引发液-液相分离？
Ying Huai,Wenjing Mao,Xuehao Wang et al.
Ying Huai et al.
RNA-binding proteins (RBPs) lie at the center of post-transcriptional regulation and protein synthesis, adding complexity to RNA life cycle. RBPs also participate in the formation of membrane-less organelles (MLOs) via undergoing liquid-liq...
Thrombin cleaves recombinant soluble thrombomodulin into a lectin-like domain fragment and a fragment with protein C-activating cofactor activity [0.03%]
凝血酶将重组可溶性血栓调节蛋白裂解为类似凝集素的结构域片段和具有蛋白C激活共因子活性的片段
Hirota Yokoyama,Koichiro Tateishi,Yurie Baba et al.
Hirota Yokoyama et al.
Thrombomodulin (TM) is a transmembrane protein that plays an important role in regulating the coagulation system by acting as a cofactor for thrombin in protein C activation. Additionally, TM is involved in inflammation. Previous studies ha...
Song Chen,Xiaolei Gu,Long Qi et al.
Song Chen et al.
On June 24, 2022, the US Supreme Court overturned Roe v. Wade, which marked a further restriction on women's abortion rights in the US. It has sparked a wide range of societal reactions around the world. Women in different countries enjoy d...
Timing of parathyroidectomy for kidney transplant patients with secondary hyperparathyroidism: A practical overview [0.03%]
肾移植患者继发性甲状旁腺功能亢进的手术时机：实用概述
Bin Wang,Wei Li,Qiang Wang et al.
Bin Wang et al.
Kidney transplantation remains the best treatment for patients with end-stage kidney disease, and it could partially mitigate systemic disorders of mineral and bone metabolism caused by secondary hyperparathyroidism. However, persistent hyp...
Contemporary oral anticoagulant therapy of patients with atrial fibrillation in China: Status, obstacles, and strategies for improvement [0.03%]
中国房颤患者口服抗凝治疗现状、挑战与改进策略
Luxiang Shang,Yujiao Zhang,Yang Zhao et al.
Luxiang Shang et al.
Atrial fibrillation (AF) and subsequent stroke and death have become major public health problems in China. Oral anticoagulant (OAC) forms the backbone of prevention of AF-related stroke. However, the quality of OAC use in AF patients in Ch...
Liquid-liquid phase separation: A new perspective to understanding aging and pathogenesis [0.03%]
液-液相分离：理解衰老和疾病发病机制的新视角
Jufeng Xia
Jufeng Xia
Mounting evidence has suggested that phase separation, and especially liquid-liquid phase separation (LLPS), underlies the formation of membraneless organelles, which are supramolecular assemblies of proteins and RNA molecules in cells. The...
Epigenetic modification of Kiss1 gene expression in the AVPV is essential for female reproductive aging [0.03%]
吻激素基因在AVPV表观遗传修饰对雌性生殖衰老的作用
Ruoxi Dai,Wen Xu,Wei Chen et al.
Ruoxi Dai et al.
Female reproductive senescence is heralded by hypothalamus region-specific changes in the transcription of genes such as Kiss1 under estradiol (E2) positive feedback, associated with luteinizing hormone (LH) surge dysfunction and reproducti...
Updated information regarding acute severe hepatitis of unknown origin in children: Viewpoints of and insights from pediatricians [0.03%]
儿童原因不明急性严重肝炎的更新信息：儿科医生的观点和见解
Liping Pan,Lulu Sun,Tetsuya Asakawa et al.
Liping Pan et al.
Recently, the morbidity of acute severe hepatitis of unknown origin in children (SHIC) has tended to decrease, but this condition should not be ignored because of its uncertain but severe nature. The current study briefly summarizes updated...
Current status and perspectives of non-coding RNA and phase separation interactions [0.03%]
非编码RNA与液-液相分离的现状及展望
Yue Gao,Chunhui Liu,Tiange Wu et al.
Yue Gao et al.
Phase separation refers to a phenomenon in which different components of a cell collide and fuse with each other to form droplets such that some components are encapsulated within the droplet and some are blocked outside. It is prevalent in...
A brief summary regarding the roles of interleukin-11 in neurological diseases [0.03%]
解读白细胞介素-11在神经疾病中作用机制的研究进展
Marat Airapetov,Sergei Eresko,Polina Ignatova et al.
Marat Airapetov et al.
Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like stromal cells of the bone marrow, but there has recently been an increased interest in the cytokine. Understanding the physiological roles of cytokines will allow their use as ...