From organ replacement to functional restoration: A paradigm shift in liver failure therapy [0.03%]
从器官替代到功能恢复：肝衰竭治疗的范式转换
Yuanzhe Liu,Tong Jiang,Cong Ren et al.
Yuanzhe Liu et al.
Liver transplantation has long been the definitive treatment for end-stage liver diseases, and yet its clinical use remains constrained by donor shortages, surgical risks, and the burden of lifelong immunosuppression. Emerging regenerative ...
PRXL2B facilitates the progression of hepatocellular carcinoma and the therapeutic efficacy of oncolytic adenovirus H101 through the PI3K/AKT/PD-L1 axis [0.03%]
PRXL2B通过PI3K/AKT/PD-L1轴促进肝细胞癌的进展和溶瘤腺病毒H101的治疗效果
Ziqi Zhang,Hongli Chen,Yangming Liu et al.
Ziqi Zhang et al.
Oncolytic adenovirus H101 has shown antitumor activity in hepatocellular carcinoma (HCC), but the molecular determinants of treatment response remain unclear. In this study, a Hepa1-6 subcutaneous tumor model was established in C57BL/6 mice...
Comparative safety and efficacy of BIC/FTC/TAF versus DTG+3TC in antiretroviral treatment-naive patients with HIV as first-line regimens: A real-world cohort study [0.03%]
一线治疗方案中用于HIV初治患者BIC/FTC/TAF与DTG+3TC的疗效及安全性比较：一项真实世界队列研究
Liqin Sun,Yuxin Jiang,Stephane Isnard et al.
Liqin Sun et al.
While bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir plus lamivudine (DTG+3TC) are first-line regimens for treatment-naive people with HIV (PWH), long-term real-world head-to-head comparisons of their metabol...
Pathways to embed digital health technologies and their governance mechanisms in Long-Term Care Insurance Systems: A comparative review of Japan, South Korea, and China [0.03%]
数字化健康技术及其治理机制嵌入长期护理保险系统的路径与模式——以日本、韩国和中国为例的比较分析
Yuhan Cheng,Yue Han,Li Wang et al.
Yuhan Cheng et al.
Rapid population aging is increasing demand for long-term care (LTC), prompting many countries to institutionalize financing and service provision through long-term care insurance (LTCI). Digital health technologies are increasingly embedde...
Liver transplantation in Japan: Achievements, limitations, and future perspectives [0.03%]
日本的肝脏移植：成就、局限与未来展望
Yasuhiko Sugawara
Yasuhiko Sugawara
Liver cirrhosis (LC) represents a substantial and growing global health burden, driving high mortality through liver failure and hepatocellular carcinoma (HCC), for which liver transplantation (LT) remains the only definitive and life-savin...
Biallelic inactivation of EXT1 in patient-derived iPSCs confirms the "Two-hit" hypothesis in hereditary multiple osteochondromas [0.03%]
患者诱导多能干细胞中的EXT1双等位基因失活证实了遗传性多发骨软骨瘤的“两次打击”假说
Yali Yang,Zhenzhong Han,Guowei Li et al.
Yali Yang et al.
Hereditary Multiple Osteochondromas (HMO) is a rare autosomal dominant skeletal disorder caused by heterozygous loss-of-function mutations in EXT1 or EXT2, which encode glycosyltransferases essential for heparan sulfate (HS) biosynthesis. W...
Modeling of the hepatitis B virus life cycle and the efficacy of antivirals in human iPSC-derived hepatic organoids [0.03%]
基于人类iPSC的肝器官类器官的乙型肝炎病毒生命周期建模及抗病毒药物疗效评价
Tanbin Liu,Junming Xu,Xiaoni Chen et al.
Tanbin Liu et al.
Hepatitis B virus (HBV) infection remains a major global health burden, affecting approximately 296 million people worldwide, and yet progress in mechanistic studies and development of antivirals has been limited by the lack of physiologica...
Characteristics and management of constitutional indocyanine green excretory defect [0.03%]
体质性吲哚菁绿排泄缺陷的特征与管理
Jiaao Wang,Ziqi Hou,Jun Ji et al.
Jiaao Wang et al.
Indocyanine green (ICG) test is a popular and widely implied assessment of hepatic functional reserve (HFR) due to its safety and efficiency. However, as the application of ICG expanded, an exceedingly rare disorder, the constitutional ICG ...
Allele-specific effects of distinct SLC26A4 variants on cochlear function and transcriptomic programs in compound heterozygous models [0.03%]
SLC26A4不同复合杂合变异对听力功能及转录组程序的等位基因特异性影响
Yue Li,Yiding Yu,Yan Zhao et al.
Yue Li et al.
SLC26A4 is a major causative gene for hereditary hearing loss, its mutation spectrum shows pronounced population specificity. In Chinese populations, patients predominantly carry biallelic mutations, and compound heterozygous genotypes are ...
The orchestrated network of skin photoaging: From intercellular crosstalk to molecular signaling [0.03%]
皮肤光老化的作用网络：从细胞间串话到分子信号转导
Bingmin Li,Cong Ren,Lixia Zhang et al.
Bingmin Li et al.
Photoaging is a distinct form of pathological skin aging driven primarily by chronic ultraviolet (UV) radiation, which clinically manifests as wrinkles, dyspigmentation, and loss of elasticity. Although core molecular events induced by UV-s...