Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis [0.03%]
幽门螺旋杆菌鞭毛电机与肽聚糖相关脂蛋白的相互作用及初步晶体学分析
Xiaotian Zhou,Mohammad M Rahman,Sharmin Q Bonny et al.
Xiaotian Zhou et al.
The bacterial flagellar motor is a molecular nanomachine, the assembly and regulation of which requires many accessory proteins. Their identity, structure and function are often discovered through characterisation of mutants with impaired m...
Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs [0.03%]
一种新的胆固醇标签介导的蛋白质药物跨膜传输系统及其应用
Pengfei Zhao,Shuo Song,Zhuojun He et al.
Pengfei Zhao et al.
The main technological difficulties of developing an intracellular (transmembrane) transport system for protein drugs lie in two points: i) overcoming the barriers in the cellular membrane, and ii) loading enough protein drugs, and particul...
Immunity debt: Hospitals need to be prepared in advance for multiple respiratory diseases that tend to co-occur [0.03%]
免疫负债：医院需提前为呼吸道传染病做好准备
Ting Li,Cordia Chu,Biying Wei et al.
Ting Li et al.
As SARS-CoV-2 transitions from a pandemic to an endemic presence, a significant rise in respiratory diseases such as influenza and Mycoplasma pneumonia is challenging healthcare systems weakened by the impact of COVID-19. This commentary ex...
The immune response of hepatocellular carcinoma after locoregional and systemic therapies: The available combination option for immunotherapy [0.03%]
经局部区域和全身治疗后的肝细胞癌免疫应答：可用于免疫疗法的现有组合选项
Yuxin Duan,Hua Zhang,Tao Tan et al.
Yuxin Duan et al.
Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune environment that produces an immune response to various locoregional treatments (LRTs), which in turn affects the effectiveness of immunotherapy. Although LRTs ...
The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma [0.03%]
铜死亡相关共表达核心基因在巴雷特食管和食管腺癌中的功能及免疫作用研究
Kailin Lin,Ke Hu,Qiwen Chen et al.
Kailin Lin et al.
Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC), with approximately 3-5% of patients developing EAC. Cuproptosis is a kind of programmed cell death phenomenon discovered in recent years, which is related...
Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study [0.03%]
肌减少症与心血管和脑血管疾病风险的关联：两样本孟德尔随机化研究
Qifeng Ou,Ding Pan
Qifeng Ou
Based on the association between sarcopenia and the risk of developing cardio-cerebrovascular disease (CCVD) established by a meta-analysis by Fang et al.(Biosci Trends. 2023; 17:293-301), we have used Mendelian randomization (MR) analysis ...
Meta-Analysis
Bioscience trends. 2023 Nov 18;17(5):413-414. DOI:10.5582/bst.2023.01246 2023
Improving the accessibility of health care for internal migrants in China: Achieving the aim of equalization [0.03%]
提高中国境内流动人口医疗卫生服务可及性：均等化目标的实现路径分析
Dan Zhao,Chengchao Zhou
Dan Zhao
Although equitable access to healthcare is considered key to the health of internal migrants, more concerted efforts are needed to improve the accessibility of healthcare in low- and middle-income countries. The software CiteSpace was used ...
Call for special attention to the caregiver burden of patients with drug-resistant tuberculosis in low- and middle-income countries [0.03%]
呼吁关注低收入和中等收入国家耐药结核病患者照护者的负担问题
Shuqi Wu,Hailin Zhang,Yi Wang et al.
Shuqi Wu et al.
The tuberculosis (TB)-related caregiver burden (CB), and particularly the multidrug and extensively drug-resistant tuberculosis (M/XDR-TB)-related CB, is not rare in caregivers caring for TB patients, especially when a family member is the ...
The prognostic nutritional index and tumor pathological characteristics predict the prognosis of elderly patients with early-stage hepatocellular carcinoma after surgery [0.03%]
术前营养指数和肿瘤病理特征可预测老年早期肝细胞癌患者术后预后风险
Yafei Hu,Yulong Cai,Wenjie Ma et al.
Yafei Hu et al.
The elderly comprises over one-third of hepatocellular carcinoma (HCC) patients, however, they are not adequately represented in prognostic studies. The study aims to determine the prognostic significance of the preoperative prognostic nutr...
Genome-wide identification of mammalian cell-cycle invariant and mitotic-specific macroH2A1 domains [0.03%]
哺乳动物细胞周期不变和有丝分裂特异性macroH2A1区域的全基因组鉴定
Le Zhang,Bishan Ye,Zeqian Xu et al.
Le Zhang et al.
The histone variant macroH2A has been found to play important regulatory roles in genomic processes, especially in regulating transcriptomes. However, whether macroH2A nucleosomes are retained on mitotic chromosomes to enable maintenance of...