The APP Score: A simple serum biomarker model to enhance prognostic prediction in hepatocellular carcinoma [0.03%]
一种简单的血清生物标志物模型，可增强对肝细胞癌预后预测的能力：APP评分
Jinyu Zhang,Qionglan Wu,Jinhua Zeng et al.
Jinyu Zhang et al.
The prognosis for patients with hepatocellular carcinoma (HCC) depends on tumor stage and remnant liver function. However, it often includes tumor morphology, which is usually assessed with imaging studies or pathologic analysis, leading to...
Development and validation of a machine-learning model to predict lymph node metastasis of intrahepatic cholangiocarcinoma: A retrospective cohort study [0.03%]
肝内胆管癌淋巴结转移的机器学习模型的开发和验证：一项回顾性队列研究
Shizheng Mi,Guoteng Qiu,Zhihong Zhang et al.
Shizheng Mi et al.
Lymph node metastasis in intrahepatic cholangiocarcinoma significantly impacts overall survival, emphasizing the need for a predictive model. This study involved patients who underwent curative liver resection between different time periods...
Imaging of pulmonary cryptococcosis with consolidations or diffuse infiltrates suggests longer clinical treatment in non-HIV patients [0.03%]
影像检查显示肺隐球菌病伴实质变或双侧弥漫性浸润提示非艾滋病患者需更长的临床治疗时间
Yi Su,Yao Zhang,Qingqing Wang et al.
Yi Su et al.
This article was to summarize the clinical features and treatment course in patients with pulmonary cryptococcal infections with different imaging manifestations and to analyse the relevant factors. Categorical variables are described in th...
Sorafenib combined with TACE improves survival in patients with hepatocellular carcinoma with vascular invasion [0.03%]
索拉非尼联合TACE治疗血管侵袭性肝细胞癌患者可提高生存率
Zhiqiang Han,Ruyu Han,Yimeng Wang et al.
Zhiqiang Han et al.
Sorafenib is a recommended first-line therapy for advanced hepatocellular carcinoma (HCC). However, when used as monotherapy in patients in advanced stages, the prognosis remains suboptimal. This study aimed to evaluate the impact of transc...
Management of non-alcoholic fatty liver disease-associated hepatocellular carcinoma [0.03%]
非酒精性脂肪性肝病相关肝细胞癌的管理
Peijun Xu,Maoyun Liu,Miao Liu et al.
Peijun Xu et al.
In recent years, with the decline in HBV and HCV infections, there has been a corresponding reduction in both the morbidity and mortality of virus-associated HCC. Nevertheless, rising living standards, coupled with the increasing prevalence...
Strengthening medical facility responses to respiratory infectious diseases: Global trends, challenges, and innovations post-COVID-19 [0.03%]
新冠肺炎后呼吸系统传染病时代加强医疗机构应对能力：全球趋势、挑战与创新举措
Xiaohe Li,Bing Han,Yafan Chen et al.
Xiaohe Li et al.
Respiratory infectious diseases have long been a serious public health problem. This study explores the significance of respiratory infectious disease prevention and control systems worldwide, particularly during and after the COVID-19 pand...
FNDC5/Irisin mitigates high glucose-induced neurotoxicity in HT22 cell via ferroptosis [0.03%]
FNDC5/irisin通过铁死亡缓解高糖诱导的HT22细胞神经毒性
Lingling Yang,Xiaohan Zhou,Tian Heng et al.
Lingling Yang et al.
Diabetes-induced neuropathy represents a major etiology of dementia, highlighting an urgent need for the development of effective therapeutic interventions. In this study, we explored the role of fibronectin type III domain containing 5 (FN...
mFOLFOX-HAIC+lenvatinib+PD-1 inhibitors versus GC/GS/GEMOX chemotherapy as a first line therapy for advanced biliary tract cancer: A single-center retrospective cohort study [0.03%]
一项单中心回顾性队列研究：mFOLFOX-HAIC+lenvatinib+PD-1抑制剂与吉西他滨/顺铂、吉西他滨/丝裂霉素和吉西他滨联合奥沙利铂一线治疗晚期胆道癌的比较
Zhipeng Sun,Hai Xu,Lei Yang et al.
Zhipeng Sun et al.
Biliary tract tumors (BTC) account for about 3% of all digestive system tumors, with rising incidence and limited treatment options, particularly for advanced stages, underscoring the need for innovative therapies. This retrospective cohort...
Blocking progression from intervenable mild cognitive impairment to irreversible dementia, what can we do? [0.03%]
可干预的轻度认知障碍进展为不可逆性痴呆，我们能做些什么？
Yaohan Peng,Peipei Song,Takashi Karako et al.
Yaohan Peng et al.
With the rapid growth of the elderly population, dementia has become a global challenge that governments must address. Given the incurable nature of dementia, rehabilitation interventions starting in the mild cognitive impairment (MCI) stag...
Exploring the multiple therapeutic mechanisms and challenges of mesenchymal stem cell-derived exosomes in Alzheimer's disease [0.03%]
探究间充质干细胞衍生的外泌体在阿尔茨海默病中多种治疗机制和挑战
Ya-Nan Ma,Xiqi Hu,Kenji Karako et al.
Ya-Nan Ma et al.
Alzheimer's disease (AD) is a severe neurodegenerative disorder, and the current treatment options are limited. Mesenchymal stem cell-derived exosomes (MSC-Exos) have garnered significant attention due to their unique biological properties,...