Adriamycin-induced nephropathy models: elucidating CKD pathophysiology and advancing therapeutic strategies [0.03%]
阿霉素肾病模型：阐明CKD发病机制及推进治疗策略
Masaki Watanabe,Hayato R Takimoto,Nobuya Sasaki
Masaki Watanabe
The Adriamycin-induced nephropathy (AN) model plays a crucial role in advancing our understanding of and research on chronic kidney disease (CKD). This review outlines methodologies for generating AN models in mice and rats, discusses their...
Morphological analysis of autophagy in axonal degeneration in gracile axonal dystrophy mice [0.03%]
颗粒齿索轴突营养不良小鼠中自噬在轴突变性中的形态分析
Yusuke Tokuhara,Shinichiro Ukon,Shohei Watanabe et al.
Yusuke Tokuhara et al.
Gracile axonal dystrophy (gad) mutant mice present with autosomal recessive inherited sensory ataxia in the early stages, followed by age-dependent motor ataxia. This phenotype is caused by a mutation in the ubiquitin carboxyl-terminal hydr...
Transcriptomics and metabolomics analysis of the pathogenesis of a novel hyperlipidemia-susceptible rat strain [0.03%]
新的易发高脂血症大鼠品系发病机制的转录组和代谢组分析
Xiufeng Ai,Qian Zhang,Quanxin Ma et al.
Xiufeng Ai et al.
To investigate the pathogenesis of hyperlipidemia in Wistar-SD Hypercholesterolemia (WSHc) rats and clarify the genetic and biological characteristics. Six 7-8-week-old WSHc rats were fed a high-fat diet (HFD), and another six were fed ordi...
High-frequency ultrasound for assessing the renal characteristics of spontaneous type 2 diabetes mellitus db/db mice [0.03%]
高频超声用于评估自发性2型糖尿病db/db小鼠肾脏特点的方法研究
Jiazhi Cao,Hao Feng,Lutong Li et al.
Jiazhi Cao et al.
There are few ultrasonographic studies on the spontaneous T2DM db/db mouse. Our objective was to dynamically investigate and assess renal morphological and hemodynamic changes in spontaneous type 2 diabetes mellitus db/db mice through high-...
Enhancing the neural differentiation capabilities of genetically asymmetric mouse F1 hybrid embryonic stem cell lines [0.03%]
增强基因遗传不对称的小鼠F1杂合胚胎干细胞的神经分化能力
Ayaka Saito,Hidemasa Kato,Hidenori Kiyosawa
Ayaka Saito
Allele-specific, monoallelic expression in diploid organisms represents an extreme case of allelic imbalance resulting from incompatibility between cis- and trans-elements. Due to haploinsufficiency, such monoallelic expression can lead to ...
Identification of gene mutations associated with the phenotype of short-limb mice emerging from a foundation colony of severely immunodeficient mice [0.03%]
利用重度免疫缺陷小鼠品系建立的基础群中出现的短肢表型定位和鉴定致病基因突变
Yui Kaneko,Kayo Tomiyama,Masahiko Yasuda et al.
Yui Kaneko et al.
Here, we report the identification of causative genes for limb-shortening in individuals repeatedly found in a population of severely immunodeficient NOG mice maintained via sibling mating. First, we conducted a pedigree survey to determine...
Melinjo (Gnetum gnemon L.) seed extract for treatment of sleep/wake fragmentation in diet-induced obese mice [0.03%]
采用梅林جو(Gnetum gnemon L.)种子提取物治疗饮食诱导的肥胖小鼠睡眠/觉醒片段化问题的研究
Mao Sato,Chiaki Sugiura,Nobuaki Okumura et al.
Mao Sato et al.
Dietary supplementation with melinjo (Gnetum gnemon L.) seed extract (MSE) has been an integral part of an anti-obesity therapeutic regimen. To examine the relationship between anti-obesity and sleep, we explored the effect of MSE on sleep ...
Endothelial GATA3 is involved in coagulofibrinolytic homeostasis during endotoxin sepsis [0.03%]
内皮细胞GATA3参与内毒素脓毒症中的凝溶纤维蛋白原稳态过程
Moyuru Hayashi,Shin&#x;ya Ohmori,Yoshiko Kawai et al.
Moyuru Hayashi et al.
Sepsis-induced acute lung injury represents a significant threat to human health and is frequently associated with pulmonary thrombosis due to dysregulation of the coagulofibrinolytic system. Plasmin, the major protease that degrades fibrin...
Xiaoqi Chang,Jiping Gao,Junting Yang et al.
Xiaoqi Chang et al.
Hamsters are valuable rodent models that are distinct from mice and rats. Currently, the main hamster species used for experimental research are the Syrian golden hamster and Chinese hamster, in addition to hamster species from other countr...
Optimization of inhaled anesthesia for Octodon degus using electroencephalography [0.03%]
基于脑电图优化Degu(Octodon degu)的吸入式麻醉
Yuki Ikai,Goro A Nagura-Kato,Shinsuke H Sakamoto et al.
Yuki Ikai et al.
Physiological responses to inhaled anesthetics vary among species. Therefore, a precise anesthetic technique is important for each individual species. In this study, we focused on the degu (Octodon degus), a small herbivorous rodent. Degus ...