Non-invasive individual identification of adult Pleurodeles waltl using Deep Learning [0.03%]
基于深度学习的成人肋腹滑体 lizard(Pleurodeles waltl)非侵入性个体识别
Kosuke Kagamiyama,Naofumi Saiki,Kosuke Takaya et al.
Kosuke Kagamiyama et al.
Reliable individual identification is essential for long-term tracking and reproducible laboratory animal studies. In amphibians, invasive marking methods like tags and dye injections can cause welfare concerns and may be unreliable because...
The peroneal muscular atrophy mousehas aberrant projection of spinal motor axons to the gluteal region [0.03%]
腓骨肌萎缩症小鼠的脊髓运动轴突向臀部区域的投射异常
Kazuko Keino-Masu,Yuta Mitani,Takuya Okada et al.
Kazuko Keino-Masu et al.
The peroneal muscular atrophy (pma) mouse shows congenital clubfoot due to atrophy of the peroneal muscles caused by lack of peroneal nerve innervation. Although it was reported that the peroneal nerve was absent in pma embryos, specific an...
Loss of TMC7 causes male infertility with disrupted spermiogenesis in mice [0.03%]
TMC7缺失导致小鼠精子形成障碍和雄性不育
Yumiao Qiu,Yuki Hiradate,Chen Pan et al.
Yumiao Qiu et al.
Spermatogenesis is a highly ordered developmental process that occurs in the seminiferous tubules and involves mitotic proliferation of spermatogonial stem cells, meiotic division of spermatocytes, and post-meiotic spermiogenesis, ultimatel...
Involvement of CD72 in membranoproliferative glomerulonephritis induced by Plasmodium chabaudi AS infection in NC/Jic mice [0.03%]
疟原虫感染小鼠系膜增生性肾炎与CD72有关
Yuki Miyasaka,Shunsuke Fujii,Yuko Shibata et al.
Yuki Miyasaka et al.
NC/Jic mice infected with the rodent malaria parasite Plasmodium chabaudi AS (P. chabaudi AS) develop membranoproliferative glomerulonephritis (MPGN), a Type III hypersensitivity reaction. MRL/MpJ-lpr/lpr (MRL/lpr) mice, a murine model of s...
Changes in microbial prevalence in mice within Japanese academic animal facilities between 2011 and 2024 [0.03%]
日本学术动物设施内小鼠微生物菌株流行率在2011年至2024年的变化
Hanako Morita,Mai Tanaka,Yurina Tomiyama et al.
Hanako Morita et al.
The microbiological quality of laboratory animals evolves along with changes in the research environment. To identify recent trends in modern Japanese research facilities, this study analyzed longitudinal contamination data for 16 major pat...
T cell transfer into immunodeficient mice uncovers a paralytic phenotype beyond colitis [0.03%]
向免疫缺陷型小鼠中转移T细胞揭示了结肠炎之外的瘫痪表型
Rumi Katsumoto,Shin Ebihara
Rumi Katsumoto
Adoptive transfer of CD45RBhigh T cells into immunodeficient mice is a well-established model for inducing colitis. Here, we report for the first time that a subset of these mice unexpectedly developed paralysis, a phenotype resembling expe...
A viral FLIP protein, E8, exogenously-expressed in the mesenchymal lineage of mice leads to bone malformations, lipoatrophy, and muscular atrophy [0.03%]
一种病毒FLIP蛋白E8在小鼠间质系中异位表达导致骨畸形、脂营养不良和肌萎缩
Kazuhiro Sakamaki,Nobuyuki Yajima,Yasumasa Okazaki et al.
Kazuhiro Sakamaki et al.
The equine herpes virus 2, E8 protein is a member of the viral FLIP family, and as such, it is a potent inhibitor of death receptor-induced apoptosis in cultured cells. To extend our study of the effects of E8 to animals, we generated a mou...
Topical administration of testosterone ameliorates atopic dermatitis of KFRS4 rats [0.03%]
睾酮局部给药可改善KFRS4小鼠湿疹症状
Kenta Hayashi,Kana Nagasaka,Haruki Kitazume et al.
Kenta Hayashi et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder influenced by genetic, environmental, and immunological factors, and its prevalence shows notable sex‑associated differences. KFRS4 rats spontaneously develop AD‑like dermatit...