Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model [0.03%]
雄性小鼠应激后的感官接触影响雌性小鼠旁观者应激模型中的社会行为反应
Yuhei Yajima,Aki Takahashi,Atsushi Toyoda
Yuhei Yajima
Depression affects females more than males, with responses to antidepressants also exhibiting a distinct difference between sexes. Stress models in rodents have predominantly been developed for males, and their application in females remain...
Akari Yamauchi,Sachiyo Enju,Kanako Sone et al.
Akari Yamauchi et al.
Mammalian hibernation is an adaptive strategy for surviving harsh cold seasons and food scarcity by suppressing the metabolic rate and thermogenesis. The Syrian hamster (Mesocricetus auratus) (hereafter termed as hamsters), a small mammalia...
Activation of autophagy through Sirt1/AMPK/mTOR mediates the protective effects of fraxin against insulin resistance and steatosis in rats [0.03%]
通过Sirt1/AMPK/mTOR激活自噬介导了远志酸抗胰岛素抵抗和脂肪变性的保护作用： rat研究
Yang Li,Xinchang Feng,Lingpeng Zheng
Yang Li
Insulin resistance (IR) and hepatic steatosis are key pathological features of type 2 diabetes mellitus (T2DM). Fraxin, a natural flavonoid with potential metabolic regulatory properties, has been proposed to modulate metabolic disorders. T...
Comparative study of renal filtration barrier structure and key gene expression between Lepus yarkandensis and Oryctolagus cuniculus [0.03%]
两种兔类肾滤过屏障结构及关键基因表达的比较研究
Siquan Liao,Dandan Peng,Bing Chao et al.
Siquan Liao et al.
The Lepus yarkandensis (L. yarkandensis) is an endemic species inhabiting the arid ecosystem of the Tarim Basin, characterized by extreme dryness and scarce water resources. In contrast, Oryctolagus cuniculus (O. cuniculus) is adapted to te...
Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and Phf24-null rat [0.03%]
PHF24蛋白对自发性全面强直阵挛性抽搐模型脑形态的双向调节作用：Noda自发性癫痫大鼠（NER）与Phf24敲除小鼠
Yuki Numakura,Miyuu Tanaka,Takeshi Izawa et al.
Yuki Numakura et al.
Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in int...
Repeated surgical oocyte collection from severe immunodeficient NOG mice after repeated superovulation with inhibin antiserum and eCG [0.03%]
抗抑制素血清和促超数排卵处理后严重免疫缺陷型NOG小鼠的多次取卵实验研究
Kumiko Takezawa,Motohito Goto,Kanako Oda et al.
Kumiko Takezawa et al.
Repeated surgical oocyte collection in mice enables the harvest of multiple cohorts of eggs from a single female, thereby reducing the need for animal use. Traditionally, oocyte collection for the mouse requires euthanasia, and only two seq...
Effects of sex hormones on the development of diabetes and pancreatic islet gene expression in obese type 2 diabetes model ZFDM rat [0.03%]
性激素对肥胖型2型糖尿病模型ZFDM大鼠糖尿病发展及胰岛基因表达的影响
Norihide Yokoi,Saki Shigenaka,Chiaki Nakata et al.
Norihide Yokoi et al.
Sex differences have been observed in the onset of type 2 diabetes, with men being more likely to develop the disease than women. There is a clear sex difference in the development of diabetes in obese type 2 diabetes model ZFDM rats, with ...
PacBio long-read amplicon sequencing of dog leukocyte antigen genes at full-length level in beagle dogs [0.03%]
利用贝灵顿梗犬全长扩增子 PacBio 长读长测序研究狗白细胞抗原基因
Hiroya Konno,Jiro Miyamae,Rei Kajitani et al.
Hiroya Konno et al.
The major histocompatibility complex (MHC) plays a critical role in individual immune responses and susceptibility to various conditions, including autoimmune diseases and drug reactions. In dogs, the canine MHC (dog leukocyte antigen, DLA)...
Asahi Haijima,Hirohiko Imai,Natsuki Matsushita et al.
Asahi Haijima et al.
The Cre-loxP system has been widely used in neuroscience for spatial and temporal control of gene expression. Although it is considered a powerful genetic tool, increasing evidence suggests that the Cre recombinase itself, without targeting...
Menstrual cycles, lifespan, and anti-Müllerian hormone in cynomolgus monkeys [0.03%]
食蟹猴的月经周期、寿命和抗穆勒管激素水平关系研究
Akie Takebayashi,Shunichiro Tsuji,Tadashi Sankai et al.
Akie Takebayashi et al.
The cynomolgus monkey (Macaca fascicularis) is an important experimental animal; however, its menstrual patterns, lifespan, and age-related changes in anti-Müllerian hormone (AMH) levels remain poorly characterized. This study aimed to ana...