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Comparison of the characteristics of non-alcoholic fatty liver disease in Leprem1hwl and Leprdb/db mice [0.03%] lepprem1-hW/l和Leprdb/db小鼠非酒精性脂肪肝的特征比较
Seungwoo Lee,Jae-Hong Min,Myoung Jun Kim et al. Seungwoo Lee et al.
The Lepr gene encodes a receptor for leptin, a hormone instrumental in the regulation of appetite and metabolism. Mutations in the Lepr gene impair leptin signaling, leading to metabolic dysfunctions and facilitating the development of non-...
Himeka Hayashi,Hirotaka Sakamoto Himeka Hayashi
The ratio of the second and fourth digits (2D:4D) is a morphological marker reflecting fetal exposure to sex steroid hormones. This ratio exhibits sexual dimorphism, with males typically showing a significantly lower ratio than females, whi...
Luminescent mouse model of endometriosis: three-dimensional morphology of lesions and cytokine profiles [0.03%] 发光的小鼠子宫内膜异位症模型：病灶的三维形态和细胞因子谱型
Nanda Yuli Rahmawati,Tra Thi Huong Dinh,Tomona Oikawa et al. Nanda Yuli Rahmawati et al.
The pathophysiology of endometriosis remains incompletely understood, necessitating the development of effective animal models for research. We generated and characterized a luminescent endometriosis mouse model utilizing luminescent B6-CAG...
Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice [0.03%] 非经典的翻译起始因子缺失会影响小鼠围产期心脏功能
Takehiro Asai,Ryota Tochinai,Yoshiharu Tsuru et al. Takehiro Asai et al.
Translation regulation is crucial for cellular homeostasis. Recent studies have demonstrated that, in addition to the conventional AUG start codon, eukaryotic mRNA can also possess non-canonical start codons. These non-canonical start codon...
Acot1 overexpression alleviates heart failure by inhibiting oxidative stress and cardiomyocyte apoptosis through the Keap1-Nrf2 pathway [0.03%] ACOT1过表达通过Keap1-Nrf2途径抑制氧化应激和心肌细胞凋亡从而改善心力衰竭
Xiaolu Hou,Guoling Hu,Heling Wang et al. Xiaolu Hou et al.
Heart failure (HF) is a clinical syndrome related to multiple causes, including oxidative stress. Acyl-CoA thioesterase 1 (Acot1) is an enzyme in fatty acids metabolism, but it remains unclear in HF. Transverse aortic coarctation induced HF...
Dual-route medetomidine-alfaxalone-butorphanol anesthesia: a refined protocol for balanced anesthesia in male rabbits [0.03%] 用于雄兔平衡麻醉的双通路美托咪啶-阿法罗唑-丁丙诺啡麻醉方案：一种精炼的方法
Risa Iwanaga,Munekatsu Ita,Kanako Sumi et al. Risa Iwanaga et al.
Injectable anesthesia is widely used in laboratory animals because of its ease of administration and minimal equipment requirements. However, it necessitates careful monitoring as well as thermal and oxygen support. This study evaluated the...
Reference intervals for hematologic and biochemical values in cynomolgus monkeys from different breeding populations in China [0.03%] 源于中国不同实验动物繁育单位食蟹猴血液及生化指标参考区间研究
Shuyan Wang,Yongtao Liu,Caiyun Li et al. Shuyan Wang et al.
The cynomolgus monkey is the most widely used models in non-clinical studies. As factors like age, gender, and breeding province may affect hematologic and serum biochemical parameters, it is important to establish base values of these para...
A novel early onset spinocerebellar ataxia 13 BAC mouse model with cerebellar atrophy, tremor, and ataxic gait [0.03%] 一种新的早发性脊髓小脑共济失调13 BAC小鼠模型，具有小脑萎缩、震颤和共济失调步态的特点
Junxiang Yin,Jerelyn A Nick,Swati Khare et al. Junxiang Yin et al.
Spinocerebellar ataxia 13 (SCA13) is an autosomal dominant neurological disorder caused by mutations in KCNC3. Our previous studies revealed that KCNC3 (Potassium Voltage-Gated Channel Subfamily C Member 3)mutation R423H results in an early...
TFRC knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis [0.03%] TFRC敲低通过抑制心肌细胞铁死亡和心脏纤维化来减轻心房颤动
Yufei Zhan,Yang Zhou,Chi Zhang et al. Yufei Zhan et al.
Atrial fibrillation (AF) is a common arrhythmia in clinical. Its most important pathophysiological factor is atrial fibrosis. Transferrin receptor (TFRC) promotes ferroptosis by facilitating iron uptake. Its role in AF is unknown. TFRC expr...
The usefulness of HbA1c measurement in diabetic mouse models using various devices [0.03%] 各种设备在糖尿病小鼠模型中测量糖化血红蛋白(HbA1c)的意义
Kohya Miyazaki,Aisha Yokoi,Hiroyuki Inoue et al. Kohya Miyazaki et al.
In most cases, the diagnosis of diabetes in animal models is based solely on blood glucose levels. While hemoglobin A1c (HbA1c) is widely used in the diagnosis of diabetes in humans, it is rarely measured in mice in diabetes research. This ...