Nicardipine co-administered with medetomidine-midazolam-butorphanol anesthesia attenuates post-anesthetic hypothermia in rats [0.03%]
Takeru Sasaki,Masaki Watanabe,Eisuke Hishida et al.
Takeru Sasaki et al.
Medetomidine-midazolam-butorphanol (MMB) anesthesia is widely used in laboratory rodents but is frequently accompanied by peri- and post-anesthetic hypothermia. This study examined whether co-administration of nicardipine could attenuate hy...
Honghe Fujie lotion ameliorates pregnancy-associated vulvovaginal candidiasis in mice by inhibiting the activation of NLRP3 inflammasome [0.03%]
红花复捷搽剂通过抑制NLRP3炎性小体活化改善小鼠妊娠相关外阴阴道念珠菌病
Ying Wang,Yiqun Jiang,Simao Shi et al.
Ying Wang et al.
Vulvovaginal candidiasis, a common infection of the female reproductive tract, poses heightened risks when occurring during pregnancy (pVVC). Although Honghe Fujie lotion (HFL), a traditional Chinese medicine, is clinically used for mycotic...
Neuroprotective effect of safflower yellow in mice with cerebral ischemia reperfusion injury [0.03%]
藏红花黄色素对脑缺血再灌注损伤小鼠的神经保护作用
Wachiryah Thong-Asa,Chaloemchai Aunkeaw,Panutda Prongfa
Wachiryah Thong-Asa
Safflower yellow (SY), a bioactive compound from Carthamus tinctorius L., possesses potent antioxidant and anti-inflammatory properties and may exert protective effects on vulnerable brain regions during acute global ischemia. Therefore, th...
Effects of plant flavonoids and selenium on pancreatic hormones and glucose homeostasis in autoimmune thyroiditis [0.03%]
植物黄酮和硒对自身免疫性甲状腺炎胰岛素和葡萄糖稳态的影响
Khasan Kayumov,Lubov Kuchkarova,Dilnoza Romanova et al.
Khasan Kayumov et al.
Autoimmune thyroiditis (AIT) is a systemic autoimmune disorder that extends beyond thyroid dysfunction and is associated with disturbances in pancreatic endocrine secretion and glucose metabolism. The present study aimed to evaluate the eff...
Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model [0.03%]
雄性小鼠应激后的感官接触影响雌性小鼠旁观者应激模型中的社会行为反应
Yuhei Yajima,Aki Takahashi,Atsushi Toyoda
Yuhei Yajima
Depression affects females more than males, with responses to antidepressants also exhibiting a distinct difference between sexes. Stress models in rodents have predominantly been developed for males, and their application in females remain...
Akari Yamauchi,Sachiyo Enju,Kanako Sone et al.
Akari Yamauchi et al.
Mammalian hibernation is an adaptive strategy for surviving harsh cold seasons and food scarcity by suppressing the metabolic rate and thermogenesis. The Syrian hamster (Mesocricetus auratus) (hereafter termed as hamsters), a small mammalia...
Activation of autophagy through Sirt1/AMPK/mTOR mediates the protective effects of fraxin against insulin resistance and steatosis in rats [0.03%]
通过Sirt1/AMPK/mTOR激活自噬介导了远志酸抗胰岛素抵抗和脂肪变性的保护作用： rat研究
Yang Li,Xinchang Feng,Lingpeng Zheng
Yang Li
Insulin resistance (IR) and hepatic steatosis are key pathological features of type 2 diabetes mellitus (T2DM). Fraxin, a natural flavonoid with potential metabolic regulatory properties, has been proposed to modulate metabolic disorders. T...
Comparative study of renal filtration barrier structure and key gene expression between Lepus yarkandensis and Oryctolagus cuniculus [0.03%]
两种兔类肾滤过屏障结构及关键基因表达的比较研究
Siquan Liao,Dandan Peng,Bing Chao et al.
Siquan Liao et al.
The Lepus yarkandensis (L. yarkandensis) is an endemic species inhabiting the arid ecosystem of the Tarim Basin, characterized by extreme dryness and scarce water resources. In contrast, Oryctolagus cuniculus (O. cuniculus) is adapted to te...
Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and Phf24-null rat [0.03%]
PHF24蛋白对自发性全面强直阵挛性抽搐模型脑形态的双向调节作用：Noda自发性癫痫大鼠（NER）与Phf24敲除小鼠
Yuki Numakura,Miyuu Tanaka,Takeshi Izawa et al.
Yuki Numakura et al.
Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in int...
Repeated surgical oocyte collection from severe immunodeficient NOG mice after repeated superovulation with inhibin antiserum and eCG [0.03%]
抗抑制素血清和促超数排卵处理后严重免疫缺陷型NOG小鼠的多次取卵实验研究
Kumiko Takezawa,Motohito Goto,Kanako Oda et al.
Kumiko Takezawa et al.
Repeated surgical oocyte collection in mice enables the harvest of multiple cohorts of eggs from a single female, thereby reducing the need for animal use. Traditionally, oocyte collection for the mouse requires euthanasia, and only two seq...