Tensin2 deficiency transiently accelerates early-phase regenerative myofiber growth following cardiotoxin-induced injury in mice [0.03%]
Tenascin-2缺乏可瞬时加速卡毒素诱导损伤小鼠再生早期肌纤维生长
Marina Miyaki,Yusuke Komiya,Minori Nakada et al.
Marina Miyaki et al.
Tensin2 (TNS2) is a focal adhesion-associated protein that can negatively regulate insulin/insulin-like growth factor 1 (IGF-1) signaling, but its role in skeletal muscle regeneration remains unclear. To address this, we analyzed a TNS2-rel...
Artesunate ameliorates experimental colitis by suppressing intestinal inflammation and modulating the gut microbiota [0.03%]
Arte sunshine粉改善实验性结肠炎：通过抑制肠道炎症和调节肠道菌群实现
Haiyang Sun,Rujiao Jiang,Jingjing Jing et al.
Haiyang Sun et al.
Artesunate (ART) is a semi-synthetic derivative of artemisinin with well-established antimalarial activity. In this study, we demonstrate that ART treatment markedly attenuates disease severity in dextran sulfate sodium (DSS)-induced coliti...
AltEx-BE: a tool for designing splice-site-targeting gRNAs for base editing-mediated exon skipping with exon-level annotations in diverse experimental animals [0.03%]
AltEx-BE：一个针对实验动物外显子水平设计靶向剪接位点的gRNA工具
Kinari Matsumoto,Akihiro Kuno,Seiya Mizuno
Kinari Matsumoto
Pre-mRNA splicing is a conserved post-transcriptional regulatory process in eukaryotes, and mis-splicing is associated with numerous diseases. Therefore, experimentally induced exon skipping provides an important strategy for exon-level ana...
Resveratrol alleviates endometriosis via restoration of hypoxic milieu and inhibition of autoantibody deposition [0.03%]
白藜芦醇通过恢复缺氧微环境和抑制自身抗体沉积来缓解子宫内膜异位症
Yi Luo,Mio Kobayashi,Di Zhang et al.
Yi Luo et al.
Endometriosis, a chronic disease that affects about 10% of women of reproductive age, is characterized by severe pain and growth of endometrium-like tissues outside the uteri. Although several theories have been advanced for the cause of en...
Diacerein alleviates endometrial fibrosis in an intrauterine adhesion model via ferroptosis inhibition [0.03%]
二氯化茋通过抑制铁死亡改善宫腔粘连模型中的子宫内膜纤维化
Cong Shi,Jianhua Sun,Jumin Niu
Cong Shi
Intrauterine adhesion (IUA) is a significant contributor to uterine infertility, primarily characterized by endometrial fibrosis. Although diacerein exhibits anti-inflammatory and anti-fibrotic properties, its therapeutic potential in IUA r...
Keratinocyte-specific STAT3 knockout attenuates imiquimod-induced psoriasiform phenotype in mice [0.03%]
小鼠角质形成细胞特异性STAT3基因敲除削弱了咪喹莫德诱导的银屑病表型
Limin Li,Cai Zhang,Lu Chen et al.
Limin Li et al.
Signal transducer and activator of transcription 3 (STAT3) is critical in psoriasis, but keratinocyte-derived STAT3 remains unclear. This study investigated the effect of keratinocyte-specific STAT3 knockout on imiquimod (IMQ)-induced psori...
Nicardipine co-administered with medetomidine-midazolam-butorphanol anesthesia attenuates post-anesthetic hypothermia in rats [0.03%]
尼卡地平与美托咪定-咪达唑仑-布托菲诺麻醉联合使用可减轻大鼠术后低体温症
Takeru Sasaki,Masaki Watanabe,Eisuke Hishida et al.
Takeru Sasaki et al.
Medetomidine-midazolam-butorphanol (MMB) anesthesia is widely used in laboratory rodents but is frequently accompanied by peri- and post-anesthetic hypothermia. This study examined whether co-administration of nicardipine could attenuate hy...
Honghe Fujie lotion ameliorates pregnancy-associated vulvovaginal candidiasis in mice by inhibiting the activation of NLRP3 inflammasome [0.03%]
红花复捷搽剂通过抑制NLRP3炎性小体活化改善小鼠妊娠相关外阴阴道念珠菌病
Ying Wang,Yiqun Jiang,Simao Shi et al.
Ying Wang et al.
Vulvovaginal candidiasis, a common infection of the female reproductive tract, poses heightened risks when occurring during pregnancy (pVVC). Although Honghe Fujie lotion (HFL), a traditional Chinese medicine, is clinically used for mycotic...
Neuroprotective effect of safflower yellow in mice with cerebral ischemia reperfusion injury [0.03%]
藏红花黄色素对脑缺血再灌注损伤小鼠的神经保护作用
Wachiryah Thong-Asa,Chaloemchai Aunkeaw,Panutda Prongfa
Wachiryah Thong-Asa
Safflower yellow (SY), a bioactive compound from Carthamus tinctorius L., possesses potent antioxidant and anti-inflammatory properties and may exert protective effects on vulnerable brain regions during acute global ischemia. Therefore, th...
Effects of plant flavonoids and selenium on pancreatic hormones and glucose homeostasis in autoimmune thyroiditis [0.03%]
植物黄酮和硒对自身免疫性甲状腺炎胰岛素和葡萄糖稳态的影响
Khasan Kayumov,Lubov Kuchkarova,Dilnoza Romanova et al.
Khasan Kayumov et al.
Autoimmune thyroiditis (AIT) is a systemic autoimmune disorder that extends beyond thyroid dysfunction and is associated with disturbances in pancreatic endocrine secretion and glucose metabolism. The present study aimed to evaluate the eff...