Acot1 overexpression alleviates heart failure by inhibiting oxidative stress and cardiomyocyte apoptosis through the Keap1-Nrf2 pathway [0.03%] ACOT1过表达通过Keap1-Nrf2途径抑制氧化应激和心肌细胞凋亡从而改善心力衰竭
Xiaolu Hou,Guoling Hu,Heling Wang et al. Xiaolu Hou et al.
Heart failure (HF) is a clinical syndrome related to multiple causes, including oxidative stress. Acyl-CoA thioesterase 1 (Acot1) is an enzyme in fatty acids metabolism, but it remains unclear in HF. Transverse aortic coarctation induced HF...
Dual-route medetomidine-alfaxalone-butorphanol anesthesia: a refined protocol for balanced anesthesia in male rabbits [0.03%] 用于雄兔平衡麻醉的双通路美托咪啶-阿法罗唑-丁丙诺啡麻醉方案：一种精炼的方法
Risa Iwanaga,Munekatsu Ita,Kanako Sumi et al. Risa Iwanaga et al.
Injectable anesthesia is widely used in laboratory animals because of its ease of administration and minimal equipment requirements. However, it necessitates careful monitoring as well as thermal and oxygen support. This study evaluated the...
Reference intervals for hematologic and biochemical values in cynomolgus monkeys from different breeding populations in China [0.03%] 源于中国不同实验动物繁育单位食蟹猴血液及生化指标参考区间研究
Shuyan Wang,Yongtao Liu,Caiyun Li et al. Shuyan Wang et al.
The cynomolgus monkey is the most widely used models in non-clinical studies. As factors like age, gender, and breeding province may affect hematologic and serum biochemical parameters, it is important to establish base values of these para...
A novel early onset spinocerebellar ataxia 13 BAC mouse model with cerebellar atrophy, tremor, and ataxic gait [0.03%] 一种新的早发性脊髓小脑共济失调13 BAC小鼠模型，具有小脑萎缩、震颤和共济失调步态的特点
Junxiang Yin,Jerelyn A Nick,Swati Khare et al. Junxiang Yin et al.
Spinocerebellar ataxia 13 (SCA13) is an autosomal dominant neurological disorder caused by mutations in KCNC3. Our previous studies revealed that KCNC3 (Potassium Voltage-Gated Channel Subfamily C Member 3)mutation R423H results in an early...
TFRC knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis [0.03%] TFRC敲低通过抑制心肌细胞铁死亡和心脏纤维化来减轻心房颤动
Yufei Zhan,Yang Zhou,Chi Zhang et al. Yufei Zhan et al.
Atrial fibrillation (AF) is a common arrhythmia in clinical. Its most important pathophysiological factor is atrial fibrosis. Transferrin receptor (TFRC) promotes ferroptosis by facilitating iron uptake. Its role in AF is unknown. TFRC expr...
The usefulness of HbA1c measurement in diabetic mouse models using various devices [0.03%] 各种设备在糖尿病小鼠模型中测量糖化血红蛋白(HbA1c)的意义
Kohya Miyazaki,Aisha Yokoi,Hiroyuki Inoue et al. Kohya Miyazaki et al.
In most cases, the diagnosis of diabetes in animal models is based solely on blood glucose levels. While hemoglobin A1c (HbA1c) is widely used in the diagnosis of diabetes in humans, it is rarely measured in mice in diabetes research. This ...
Intestinal epithelial cell-specific restoration of Nrf2 gene in whole-body-knockout mice ameliorates acute colitis [0.03%] 肠道上皮细胞特异性Nrf2基因的恢复可缓解全身敲除小鼠急性结肠炎症状
Tatsuhiro Sato,Keii To,Fumika Sakurai et al. Tatsuhiro Sato et al.
Unbalanced redox homeostasis leads to the production of reactive oxygen species and exacerbates inflammatory bowel disease. To investigate the role of the transcription factor Nrf2, a major antioxidative stress sensor, in intestinal epithel...
Diverse Cre recombinase expression pattern in Albumin-Cre driver rats [0.03%] 斑点鼠品系Albumin-Cre启动子杂合率偏低及Cre重组酶表达模式多样问题研究
Saeko Ishida,Keiko Taguchi,Ryuya Iida et al. Saeko Ishida et al.
Rats (Rattus norvegicus) have been widely utilized as model animals due to their physiological characteristics, making them suitable for surgical and long-term studies. They have played a crucial role in biomedical research, complementing s...
Disruption of intestinal barrier and dysbiosis of gut microbiota in an experimental rhesus macaque model with 6-year diabetes mellitus [0.03%] 肠道屏障功能障碍和糖尿病恒河猴模型肠道菌群紊乱六年研究
Xiangyu Fu,Xiang Ren,Maoyuan Zhao et al. Xiangyu Fu et al.
This study aims to clarify the disruption of gut barrier and dysbiosis of the microbiota in an experimental macaque model with 6-year diabetes mellitus (DM), and provide evidence for the application of therapeutic strategies targeting the h...
Royal jelly reduced non-rapid eye movement sleep fragmentation and restored sleep stability in diet-induced obese mice [0.03%] royal jelly减少非快速眼动睡眠的片段化并恢复饮食诱导的肥胖小鼠的睡眠稳定性
Chiaki Sugiura,Mao Sato,Shun Tanaka et al. Chiaki Sugiura et al.
Royal jelly (RJ) is recognized due to its high nutritional value and potential health benefits. Previous research showed that RJ supplementation decreased fat accumulation, resulting in weight loss and improvements in hyperglycemia and insu...