Evaluation of a mixture of medetomidine, alfaxalone and butorphanol as an alternative drug for euthanasia in mice [0.03%]
评估-medetomidine、alfaxalone和butorphanol-作为小鼠安乐死替代药物的效果
Megumi Kiyoto,Kenta Nakano,Yukiyoshi Watai et al.
Megumi Kiyoto et al.
Euthanasia agents should induce a rapid and painless loss of consciousness, followed by cardiopulmonary arrest and subsequent brain death. Injectable drugs such as pentobarbital sodium are commonly used for laboratory rodents due to their q...
The protective effects of retinoic acid-induced protein 14 on ischemia/reperfusion-induced myocardial apoptosis involves over-autophagy repression [0.03%]
视黄酸诱导基因蛋白14对心肌缺血再灌注损伤的保护作用涉及过度自噬抑制作用
Junjie Xu,Lei Zhang,Peng Zhang et al.
Junjie Xu et al.
Uncontrolled activation of autophagy following ischemia/reperfusion (I/R) injury leads to cell death. The superfamily of ankyrin repeat proteins (N-Ank protein) was reported to be involved in autophagy regulation and cardiac protection. Bio...
Effect of gamma-ray exposure on the genome-editing efficiency of improved genome-editing via oviductal nucleic acids delivery (i-GONAD) [0.03%]
γ射线辐照对输卵管递送优化基因编辑（i-GONAD）效率影响的研究
Anarkhuu Bold-Erdene,Kento Miura,Norimasa Yamasaki et al.
Anarkhuu Bold-Erdene et al.
DNA double-strand breaks (DSBs) are among the most hazardous cellular damages, potentially leading to cell death or oncogenesis if unrepaired. Genome editing methods, such as the CRISPR/Cas9 system, induce DSBs and utilize these repair path...
Comparison of the characteristics of non-alcoholic fatty liver disease in Leprem1hwl and Leprdb/db mice [0.03%]
lepprem1-hW/l和Leprdb/db小鼠非酒精性脂肪肝的特征比较
Seungwoo Lee,Jae-Hong Min,Myoung Jun Kim et al.
Seungwoo Lee et al.
The Lepr gene encodes a receptor for leptin, a hormone instrumental in the regulation of appetite and metabolism. Mutations in the Lepr gene impair leptin signaling, leading to metabolic dysfunctions and facilitating the development of non-...
Himeka Hayashi,Hirotaka Sakamoto
Himeka Hayashi
The ratio of the second and fourth digits (2D:4D) is a morphological marker reflecting fetal exposure to sex steroid hormones. This ratio exhibits sexual dimorphism, with males typically showing a significantly lower ratio than females, whi...
Luminescent mouse model of endometriosis: three-dimensional morphology of lesions and cytokine profiles [0.03%]
发光的小鼠子宫内膜异位症模型：病灶的三维形态和细胞因子谱型
Nanda Yuli Rahmawati,Tra Thi Huong Dinh,Tomona Oikawa et al.
Nanda Yuli Rahmawati et al.
The pathophysiology of endometriosis remains incompletely understood, necessitating the development of effective animal models for research. We generated and characterized a luminescent endometriosis mouse model utilizing luminescent B6-CAG...
Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice [0.03%]
非经典的翻译起始因子缺失会影响小鼠围产期心脏功能
Takehiro Asai,Ryota Tochinai,Yoshiharu Tsuru et al.
Takehiro Asai et al.
Translation regulation is crucial for cellular homeostasis. Recent studies have demonstrated that, in addition to the conventional AUG start codon, eukaryotic mRNA can also possess non-canonical start codons. These non-canonical start codon...
Acot1 overexpression alleviates heart failure by inhibiting oxidative stress and cardiomyocyte apoptosis through the Keap1-Nrf2 pathway [0.03%]
ACOT1过表达通过Keap1-Nrf2途径抑制氧化应激和心肌细胞凋亡从而改善心力衰竭
Xiaolu Hou,Guoling Hu,Heling Wang et al.
Xiaolu Hou et al.
Heart failure (HF) is a clinical syndrome related to multiple causes, including oxidative stress. Acyl-CoA thioesterase 1 (Acot1) is an enzyme in fatty acids metabolism, but it remains unclear in HF. Transverse aortic coarctation induced HF...
Dual-route medetomidine-alfaxalone-butorphanol anesthesia: a refined protocol for balanced anesthesia in male rabbits [0.03%]
用于雄兔平衡麻醉的双通路美托咪啶-阿法罗唑-丁丙诺啡麻醉方案：一种精炼的方法
Risa Iwanaga,Munekatsu Ita,Kanako Sumi et al.
Risa Iwanaga et al.
Injectable anesthesia is widely used in laboratory animals because of its ease of administration and minimal equipment requirements. However, it necessitates careful monitoring as well as thermal and oxygen support. This study evaluated the...