Repeated surgical oocyte collection from severe immunodeficient NOG mice after repeated superovulation with inhibin antiserum and eCG [0.03%]
抗抑制素血清和促超数排卵处理后严重免疫缺陷型NOG小鼠的多次取卵实验研究
Kumiko Takezawa,Motohito Goto,Kanako Oda et al.
Kumiko Takezawa et al.
Repeated surgical oocyte collection in mice enables the harvest of multiple cohorts of eggs from a single female, thereby reducing the need for animal use. Traditionally, oocyte collection for the mouse requires euthanasia, and only two seq...
Effects of sex hormones on the development of diabetes and pancreatic islet gene expression in obese type 2 diabetes model ZFDM rat [0.03%]
性激素对肥胖型2型糖尿病模型ZFDM大鼠糖尿病发展及胰岛基因表达的影响
Norihide Yokoi,Saki Shigenaka,Chiaki Nakata et al.
Norihide Yokoi et al.
Sex differences have been observed in the onset of type 2 diabetes, with men being more likely to develop the disease than women. There is a clear sex difference in the development of diabetes in obese type 2 diabetes model ZFDM rats, with ...
PacBio long-read amplicon sequencing of dog leukocyte antigen genes at full-length level in beagle dogs [0.03%]
利用贝灵顿梗犬全长扩增子 PacBio 长读长测序研究狗白细胞抗原基因
Hiroya Konno,Jiro Miyamae,Rei Kajitani et al.
Hiroya Konno et al.
The major histocompatibility complex (MHC) plays a critical role in individual immune responses and susceptibility to various conditions, including autoimmune diseases and drug reactions. In dogs, the canine MHC (dog leukocyte antigen, DLA)...
Asahi Haijima,Hirohiko Imai,Natsuki Matsushita et al.
Asahi Haijima et al.
The Cre-loxP system has been widely used in neuroscience for spatial and temporal control of gene expression. Although it is considered a powerful genetic tool, increasing evidence suggests that the Cre recombinase itself, without targeting...
Menstrual cycles, lifespan, and anti-Müllerian hormone in cynomolgus monkeys [0.03%]
食蟹猴的月经周期、寿命和抗穆勒管激素水平关系研究
Akie Takebayashi,Shunichiro Tsuji,Tadashi Sankai et al.
Akie Takebayashi et al.
The cynomolgus monkey (Macaca fascicularis) is an important experimental animal; however, its menstrual patterns, lifespan, and age-related changes in anti-Müllerian hormone (AMH) levels remain poorly characterized. This study aimed to ana...
Exposure to xylene early in life induces memory abnormalities of adult male mice [0.03%]
生命早期接触甲苯可致雄性小鼠成年后学习记忆异常
Hirokatsu Saito,Kousuke Suga,Koji Fujihara et al.
Hirokatsu Saito et al.
Xylene, an aromatic hydrocarbon, is widely used as a solvent in industries, such as printing and rubber and leather manufacturing. Despite the significant industrial benefits of xylene, there are increasing concerns about its environmental ...
RNF10 is atherosclerosis protective and modulates macrophage polarization [0.03%]
RNF10具有防治动脉粥样硬化作用并调控巨噬细胞极化
Ke-Xin Zhao,Shu-Xu Jin,Ming-Hao Li
Ke-Xin Zhao
Macrophages can develop into pro-inflammatory M1-like macrophages and anti-inflammatory M2-like macrophages when stimulated by distinct internal environment. Dynamic changes of the two kinds of macrophages play key roles in atherosclerosis ...
A nonsense mutation in the Mocos gene induces xanthinuria, obstructive nephropathy, and anemia in rats [0.03%]
Mocos基因的移码突变诱导大鼠产生核黄素代谢缺陷、阻塞性肾病和贫血症
Mao Urasaki,Kana Nagasaka,Minori Kido et al.
Mao Urasaki et al.
Xanthinuria type II is a rare hereditary disorder caused by mutations in the MOCOS gene, leading to dual deficiency of xanthine dehydrogenase and aldehyde oxidase. To establish a robust animal model for this condition, we generated Mocos kn...
Neu5Ac promotes high-fat diet-induced progression of atherosclerosis in Apoe-deficient mice [0.03%]
Neu5Ac促进Apoe缺陷小鼠高脂饮食诱导的动脉粥样硬化的发展
Dong Huang,Chengyong Yin,Di Wang
Dong Huang
Atherosclerosis (AS) is a chronic inflammatory disorder underlying most cardiovascular events. Sialic acid (SIA), a terminal metabolite of glycolipid catabolism, modulates vascular injury, but its role in endothelial dysfunction remains unc...
Hematologic and biochemical changes associated with age and strain in aged B6 mice breeding in the National Center of Geriatrics and Gerontology [0.03%]
中国老龄科学研究中心小鼠老化研究中与年龄和品系有关的血液及生化变化的研究
Julio A Almunia,Yoshiko Munesue,Noboru Ogiso et al.
Julio A Almunia et al.
At the National Center of Geriatric and Gerontology (NCGG), aged mice and rats are used in research on aging and the treatment and prevention of gerontological diseases. Some of the most commonly used mouse strains in our center and general...