[Myasthenia Gravis Treated with Zilucoplan Prior to Extended Transsternal Thymectomy for the Prevention of Myasthenic Crisis: A Case Report] [0.03%]
[zilucoplan治疗胸骨全切扩大胸腺切除术前重症肌无力1例报告]
Nanami Yamanaka,Masaya Honda,So Kanda et al.
Nanami Yamanaka et al.
A 50year-old female was diagnosed with myasthenia gravis (MG) following aspiration pneumonia. Despite treatment with prednisolone (5mg/day) and intravenous immunoglobulin (IVIg), the bulbar palsy persisted. Additionally, chest CT revealed f...
[Donanemab, an Amyloid β-targeting Antibody for Early Symptomatic Alzheimer's Disease: Summary of Clinical Study Results] [0.03%]
针对阿尔茨海默病早期症状性患者的淀粉样蛋白β抗体多奈马宗临床研究结果概要
Shoichiro Sato,Atsushi Iwata,Kenji Ishii et al.
Shoichiro Sato et al.
Alzheimer's disease is an age-related neurodegenerative disorder, and is considered to contribute to dementia in 60%-70% of individuals with dementia. In recent years, a series of amyloid β protein (Aβ)-targeting antibodies that act direc...
[Neural Circuits of Saccadic Eye Movements: Insights into Active Vision] [0.03%]
主动视感知的神经环路：眼跳运动的研究进展
Mayu Takahashi
Mayu Takahashi
This article deals with the neural circuits involved in the generation and suppression of saccadic eye movements. Voluntary eye movements are known to be organized in two-dimensional horizontal and vertical coordinate system, whereas the ve...
[Aphantasia: A Cognitive Condition Characterized by the Absence of Voluntary Mental Imagery] [0.03%]
[无力想象症：一种以自愿性心理意象缺失为特征的认知条件]
Shun Kudo
Shun Kudo
"Aphantasia" refers to the inability to create voluntary mental images. Most studies have assessed aphantasia using questionnaires; however, recently, there have been attempts to quantify aphantasia using objective measures such as pupillar...
Takashi Kurashige
Takashi Kurashige
Sporadic late-onset nemaline myopathy (SLONM) is distinct from congenital nemaline myopathies, which are associated with genetic abnormalities. There are many cases of SLONM with M-proteinemia, but treatment response and life expectancy are...
Michiaki Koga
Michiaki Koga
M-protein and neuropathy are highly prevalent and often coincide without causal relationships. However, some M-proteins induce neuropathies, which are diverse and require a multifaceted approach to investigate M protein characteristics, neu...
Ryota Sato,Takashi Kanda
Ryota Sato
Anti-myelin-associated glycoprotein neuropathy is now recognized as a distinct clinicopathological entity. Since its initial description over 40 years ago, substantial advances have been made in elucidating its pathogenic mechanisms, standa...
[POEMS Syndrome] [0.03%]
诗症综合征
Tomoki Suichi,Sonoko Misawa
Tomoki Suichi
POEMS syndrome is a systemic disease characterized by monoclonal plasma cell proliferation and the overproduction of the vascular endothelial growth factor. Japanese researchers have made significant contributions to the establishment of di...
[AL Amyloidosis] [0.03%]
[淀粉样变性病]
Toshihiro Ide,Haruki Koike
Toshihiro Ide
AL amyloidosis is a systemic disease caused by misfolded immunoglobulin light chains deposited as amyloid fibrils in multiple organs. Peripheral neuropathy, which often presents with sensory dissociation and autonomic dysfunction, is a key ...
Takamitsu Watanabe
Takamitsu Watanabe
Autism spectrum disorder is characterized by socio-communicative traits and cognitive inflexibility. Here, we present a series of findings indicating that autistic neural rigidity is a key neural mechanism underpinning for both social and n...