Ikuko Takahashi-Iwata
Ikuko Takahashi-Iwata
Tuberculous meningitis is a condition in which Mycobacterium tuberculosis affects the central nervous system. Although it does not present particularly distinctive symptoms, it often diverges from the classic signs seen in other forms of me...
[Spinal Epidural Abscess] [0.03%]
脊柱硬膜外脓肿
Shiori Takahashi,Takashi Kanda
Shiori Takahashi
Spinal epidural abscess is an urgent condition that begins with neck and lower back pain, rapidly progressing to severe neurological symptoms, such as limb weakness and paraplegia. Prompt treatment is required; however, clinical signs and M...
[Brain Abscess] [0.03%]
[脑脓肿]
Yoshihisa Kawano,Taketoshi Maehara
Yoshihisa Kawano
Brain abscess is a potentially life-threatening intracranial infection progressing from localized cerebritis to an encapsulated cavity. Infection routes are classified into contiguous spread from adjacent infectious foci, hematogenous disse...
[Acute Subdural Empyema] [0.03%]
急性亚急性硬膜下脓肿
Ryosuke Hanaya
Ryosuke Hanaya
Acute subdural empyema is a severe intracranial infection characterized by purulent accumulation between the dura mater and the arachnoid. It commonly affects children and young adults, typically as a complication of sinusitis, otitis media...
Fumitaka Kono,Takeshi Matushige,Shunji Hasegawa
Fumitaka Kono
Bacterial meningitis in children is a critical emergency, and the lack of rapid diagnosis and treatment can result in a poor prognosis. Although routine immunization has lowered the incidence of bacterial meningitis and there have been adva...
[Bacterial Meningitis] [0.03%]
细菌性脑膜炎
Hideto Nakajima
Hideto Nakajima
Bacterial meningitis is a neurological emergency that requires immediate diagnosis and treatment. In adults, Streptococcus pneumoniae is the most common causative pathogen, and Listeria monocytogenes should also be considered in patients ag...
Satoshi Kamei
Satoshi Kamei
In the therapeutic management of neurological infections, corticosteroids play a selective adjunctive role and can be administered in combination with antibiotics or antivirals, depending on the pathological conditions. In adults with bacte...
Hiroyuki Murai
Hiroyuki Murai
Although sanitary conditions in Japan are generally favorable, pathogens may be introduced by patients who acquire the infections overseas. Dengue fever has a high global incidence, with nearly 200 cases occurring annually in Japan. Most of...
Fumitaka Shimizu
Fumitaka Shimizu
Central nervous system (CNS) infections are serious and potentially life-threatening complications in patients with immunodeficiency. Predisposing conditions include organ transplant, hematopoietic stem cell transplantation, Human Immunodef...
[Antibiotic Penetration into the Central Nervous System: Decoding the Blood: Brain Barrier and Antibiotics through "Structure" to Inform Therapeutic Strategy] [0.03%]
抗生素穿透中枢神经系统屏障的结构基础及策略优化
Yukio Takeshita
Yukio Takeshita
Clinical outcomes of central nervous system (CNS) infections are determined by not only pathogen coverage but also whether an antibiotic can cross the blood-brain barrier (BBB) to achieve sufficient exposure at the target site. The BBB is a...