[Immune Cells and Proteins Associated with Disease Progression in Amyotrophic Lateral Sclerosis: New Insights from Multiomics Analyses] [0.03%]
肌萎缩侧索硬化病程进展相关的免疫细胞和蛋白质：多组学分析的新见解
Koji Fujita,Naoko Matsui,Yuishin Izumi
Koji Fujita
Disease progression in amyotrophic lateral sclerosis shows substantial individual variability, and immune mechanisms have attracted attention as underlying factors. Immune profiles associated with disease progression were identified using c...
Kazuo Kitagawa
Kazuo Kitagawa
The major conditions requiring nursing care in the elderly are stroke and dementia. At institutions certified by the Brain Dock Society, individuals receive not only brain MRI and MRA but also cognitive assessments and carotid ultrasound ex...
Kenji Tagai,Takahiko Tokuda
Kenji Tagai
Blood biomarkers represent a major breakthrough in the early diagnosis of Alzheimer's disease (AD). Plasma p-tau217/Aβ42 ratio demonstrates diagnostic accuracy comparable to PET and CSF examinations, leading to FDA approval of the first bl...
[Cognitive Screening for Dementia Using Simple Neuropsychological Tests: New Developments through Digital Technology] [0.03%]
简易神经心理测验筛查认知障碍的新进展——数字化技术的应用
Shigeki Yamaguchi
Shigeki Yamaguchi
With the rapid aging population, the prevalence of dementia and mild cognitive impairment is increasing and is estimated to be >10 million by 2025 in Japan. The emergence of anti-amyloid β-antibody therapies has heightened the importance o...
Ajinkya Deepa Deepak Anjikar,Athira Padinharayil,Junpei Naito et al.
Ajinkya Deepa Deepak Anjikar et al.
Cerebral White Matter Lesions (CWMLs) contribute to normal human behavioral and memory impairments, leading to life-threatening diseases and disorders. Quantitative assessment is crucial to enable accurate microstructural diagnosis and to m...
Susumu Mori
Susumu Mori
This review clarifies the concept of dementia screening and examines its current status and challenges. Screening differs from diagnostic assessment in that it serves as an entry point for early detection and preventive intervention. Curren...
Hidekazu Tomimoto
Hidekazu Tomimoto
Recent progress of highly sensitive detection methods including digital cognitive test and AI-assisted imaging have increasingly innovated early detection of Alzheimer's disease. Moreover, blood biomarkers such as p-tau217 and MTBR-tau243, ...
[Brain Screening for Occupational Drivers: Current Practices and Future Directions] [0.03%]
职业司机脑部筛查：现状与未来方向
Akio Morita
Akio Morita
While the Industrial Safety and Health Act mandates the maintenance of workers' health, more than 100 health-related accidents involving commercial vehicles occur annually. The primary causes of these accidents include cerebrovascular, card...
[Brain Dock Guidelines and the Treatment of Asymptomatic Lesions: Criteria and Approaches] [0.03%]
[脑底异常血管网征诊疗指南和无症状性病变的治疗：标准与策略]
Michiyasu Suzuki
Michiyasu Suzuki
Asymptomatic brain lesions, such as lacunar infarction, perivascular spaces, cerebral white matter lesions, and cerebral microbleeds, neck ultrasonography, magnetic resonance imaging, atrial fibrillation, dyslipidemia, and diabetes should b...
Masafumi Ihara
Masafumi Ihara
Asymptomatic carotid or intracranial arterial stenosis, silent brain infarction, cerebral white matter lesions, and cerebral microbleeds are well-established predictors of stroke. When these findings are detected through brain screening pro...