[Charcot-Marie-Tooth Disease: Historical Evolution and Present Understanding] [0.03%]
[charcot-marie-tooth病的前世今生]
Chikashi Yano,Hiroshi Takashima
Chikashi Yano
Charcot-Marie-Tooth disease is a hereditary motor and sensory neuropathy characterized by progressive distal muscle weakness, atrophy, and sensory impairment. In this article, we review the original reports published in 1886 by Charcot, Mar...
[Success and Failure during Three Centuries of Charcot's Clinical Neuropathology: From Amyotrophic Lateral Sclerosis to Functional Neurological Disorders] [0.03%]
【查科临床神经病理学三百年：从肌萎缩侧索硬化到功能性神经系统疾病】
Toshiki Uchihara
Toshiki Uchihara
Clinical neuropathology was advanced by Charcot at la Salpêtrière Hospital in the 19th century. The lower and upper motor signs of amyotrophic lateral sclerosis were corroborated at autopsy by degeneration of the anterior horns and latera...
[Significance of Amyloid Plaque Removal in Alzheimer's Disease Treatment: Development of Amyloid β-Targeting Antibody Drugs Based on the Amyloid Cascade Hypothesis] [0.03%]
基于淀粉样级联假说的阿尔茨海默病治疗领域抗体药物研发：淀粉样蛋白斑清除的意义及抗β淀粉样蛋白药物开发进展
Hisatomo Kowa,Shoichiro Sato,Eriko Kamiki et al.
Hisatomo Kowa et al.
In a hyper-aging society, taking measures against dementia, especially against dementia due to Alzheimer's disease, which accounts for about two thirds of dementia cases, is an important task socially and economically. Forty years have pass...
Keisuke Suzuki,Hiroaki Fujita,Ryoma Takahashi et al.
Keisuke Suzuki et al.
Narcolepsy is a major central disorder of hypersomnolence that causes excessive daytime sleepiness (EDS), cataplexy, sleep paralysis and hypnagogic hallucinations due to impairment of the orexinergic system. Symptomatic narcolepsy is charac...
Taisuke Ono,Takashi Kanbayashi
Taisuke Ono
Narcolepsy is primarily characterized by excessive daytime sleepiness, which is the cardinal symptom. Additional associated symptoms include cataplexy, sleep paralysis, hypnagogic hallucinations, and nocturnal sleep fragmentation. Narcoleps...
[Restless Legs Syndrome] [0.03%]
不宁腿综合征
Yoshio Tsuboi
Yoshio Tsuboi
Restless leg syndrome (RLS) is a sensorimotor disorder characterized by unpleasant sensations in the lower limbs and an urge to move them, which often results in insomnia or difficulty in maintaining sleep. Although RLS is less prevalent in...
Takashi Nomura
Takashi Nomura
Parasomnia is an undesirable physical phenomena that occurs during sleep and is classified into three groups: non-rapid eye movement (REM), REM, and other parasomnias. Non-REM parasomnias that occur during non-REM sleep include wakefulness ...
Noriko Nishikawa
Noriko Nishikawa
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a parasomnia characterized by dream-enacting behaviors caused by the loss of muscle atonia during REM sleep. It is widely recognized as a prodromal phase of α-synucleinopa...
Hideaki Nakayama
Hideaki Nakayama
Multiple system atrophy (MSA) is a sporadic, progressive neurodegenerative disease that affects multiple systems, including the Parkinsonian and cerebellar systems. It is commonly associated with obstructive and central sleep apnea, sleep-r...
Yasuhisa Akaiwa,Tomoyuki Miyamoto
Yasuhisa Akaiwa
Obstructive sleep apnea (OSA) and cerebrovascular disease (CVD) have a bidirectional relationship. OSA serves as an independent risk factor for stroke, and a prior meta-analysis has demonstrated a 2.24-fold increased risk for stroke develop...