Takahiro Shimizu,Noboru Mizushima
Takahiro Shimizu
Autophagy is an essential degradation mechanism that maintains intracellular homeostasis. In recent years, an increasing number of cases with mutations in autophagy-related genes, such as ATG7, have been reported. These findings highlight t...
Yohei Mukai
Yohei Mukai
Postural abnormalities are relatively common in Parkinson's disease (PD), affecting roughly 20-30% of patients. These abnormalities include camptocormia, Pisa syndrome, and dropped head syndrome, but the mechanisms of these abnormalities re...
Masayuki Miyamoto
Masayuki Miyamoto
Insomnia, one of the non-motor symptoms of Parkinson's disease (PD), affects approximately 80% of patients with advanced-stage PD. In such cases, it is necessary to evaluate and treat the condition with the understanding that various factor...
Kenichi Kashihara
Kenichi Kashihara
Patients with Parkinson's disease (PD) often develop hypersexuality. Hypersexuality occurs in impulse control disorders (ICD), which are caused by dopamine replacement therapy. Hypersexuality becomes a burden for patients, their spouses, an...
Masato Asahina
Masato Asahina
Orthostatic hypotension (OH) is a major problem in patients with Parkinson's disease (PD), necessitating careful management by neurologists. Furthermore, understanding the relationship between OH and other non-motor symptoms provides valuab...
Taku Hatano,Hikaru Kamo
Taku Hatano
Falls represent critical clinical events in older people, leading to functional decline, fractures, and deterioration in their ability to perform activities of daily living and decreased cognitive abilities, resulting in a bedridden state. ...
[Psychiatric Symptoms in Parkinson's Disease: Epidemiology, Pathophysiology, and Therapeutic Strategies] [0.03%]
帕金森病的精神症状：流行病学、病理生理及治疗策略
Hiroyuki Takenaka,Toru Baba,Atsushi Takeda
Hiroyuki Takenaka
Although traditionally classified as a movement disorder due to nigrostriatal dopamine loss, Parkinson's disease also manifests a wide range of psychiatric symptoms across the disease course from prodromal phase to advanced stages. These ps...
Yoshiyuki Nishio
Yoshiyuki Nishio
The timing of dementia onset in patients with Parkinson's disease varies significantly. Predictors of the early development of dementia include postural instability, gait disturbance, REM sleep behavior disorder, and visuo-spatial impairmen...
[Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Challenges of Standard Treatments and Prospects for New Therapies] [0.03%]
慢性炎症性脱髓鞘多发神经病：常规治疗的挑战及新的治疗方法展望
Satoshi Kuwabara,Nozomu Tanaka,Koichi Tsuda et al.
Satoshi Kuwabara et al.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy and patients suffer from muscle weakness and impaired quality of life. Current standard treatments for CIDP include immunoglobulin, corticoste...
Akihiro Yugeta
Akihiro Yugeta
Deep brain stimulation (DBS) has been a common treatment for Parkinson's disease, tremors, and dystonia since its approval in Japan for movement disorders in 2000. In the EU and USA, DBS has been studied as a therapeutic option for depressi...