Galyna P Volynets,Olga S Iungin,Olga I Gudzera et al.
Galyna P Volynets et al.
Staphylococcus aureus is one of the most common nosocomial biofilm-forming pathogens worldwide that has developed resistance mechanisms against majority of the antibiotics. Therefore, the search of novel antistaphylococcal agents with unexp...
Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06 [0.03%]
HU02-06菌株的两个新的芳香tenvermectins类化合物
Hui Zhang,Zhen-Yu Wang,Huan Qi et al.
Hui Zhang et al.
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were established by extensive spectroscop...
Inhibition of the ATP synthase increases sensitivity of Escherichia coli carrying mcr-1 to polymyxin B [0.03%]
ATP合成酶抑制作用通过增加多黏菌素B对携带mcr-1基因的大肠杆菌的敏感性来发挥抗菌作用
Zheng Fan,Zhoufei Li,Tongtong Fu et al.
Zheng Fan et al.
Bacterial infections caused by multidrug-resistant (MDR) gram-negative strains carrying the mobile colistin resistance gene mcr-1 are serious threats to world public health due to the lack of effective treatments. Inhibition of the ATP synt...
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27 [0.03%]
头孢他啶通过增加细胞p27水平抑制细胞增殖
Tingting Zhang,Caixia Qiao,Yunshan Yang et al.
Tingting Zhang et al.
The development of new therapeutic uses for existing drugs is important for the treatment of some diseases. Cephalosporin antibiotics stand as the most extensively utilized antibiotics in clinical practice, effectively combating bacterial i...
Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins [0.03%]
3',6-二取代斯必替霉素的合成及其抗菌活性
Suresh Dharuman,Gregory A Phelps,Christine M Dunn et al.
Suresh Dharuman et al.
Spectinomycin is an aminocyclitol antibiotic with a unique ribosomal binding site. Prior synthetic modifications of spectinomycin have enhanced potency and antibacterial spectrum through addition at the 6'-position to produce trospectomycin...
Suresh K Mondal,Sk Aftabul Alam,Gourisankar Roymahapatra et al.
Suresh K Mondal et al.
Antibiotic resistant is the major concern in public health to control the infectious diseases. MRSA (Methicillin-resistant Staphylococcus aureus) is a significant concern in healthcare settings due to its resistance to many antibiotics, inc...
Reversal of carbapenem resistance in Pseudomonas aeruginosa by camelid single domain antibody fragment (VHH) against the C4-dicarboxylate transporter [0.03%]
骆驼单域抗体片段(VHH)片段对抗Pseudomonas aeruginosa C4-二羧基转运蛋白以逆转其碳青霉烯类耐药性
Anil Kumar Nagraj,Manjiri Shukla,Mansi Kulkarni et al.
Anil Kumar Nagraj et al.
Antimicrobial resistance is emerging as the new healthcare crisis necessitating the development of newer classes of drugs using non-traditional approaches. Pseudomonas aeruginosa, one of the most common pathogens involved in nosocomial infe...
From inside to outside: exploring extracellular antimicrobial histone-derived peptides as multi-talented molecules [0.03%]
从内到外：探究抗菌组蛋白衍生的胞外多肽分子的多种功能
Carolina Muñoz-Camargo,Juan C Cruz
Carolina Muñoz-Camargo
The emergence of bacterial resistance to antibiotics poses a global health threat, necessitating innovative solutions. The contemporary challenge lies in bacterial resistance, impacting morbidity, mortality, and global economies. Antimicrob...
Oznur Caliskan-Aydogan,Chloe Zaborney Kline,Evangelyn C Alocilja
Oznur Caliskan-Aydogan
Characterizing the physiological response of bacterial cells to antibiotics is crucial for designing diagnostic techniques, treatment choices, and drug development. While bacterial cells at sublethal doses of antibiotics are commonly charac...
Structure revision of tricholomenyn B, an antimitotic geranylcyclohexenone rediscovered as a bitter and antibacterial substance, from a basidiomycete Tricholoma japonicum (Shiro-shimeji) [0.03%]
来源于伞菌(tricholoma japonicum)的抗有丝分裂成分tricholomenyn B结构重排及苦味和抗菌活性研究
Md Julkar Nime,Yuna Oguri,Naoya Oku et al.
Md Julkar Nime et al.
Tricholomenyn B, an antimitotic geranylcyclohexenone originally discovered from a basidiomycete Tricholoma acerbum, was isolated as a bitter and antibacterial constituent from fruiting bodies of T. japonicum. Careful comparison of NMR, MS, ...