Litchficin, a germination inhibitory acyloin from a halophilic Gram-positive bacterium of the genus Litchfieldia [0.03%]
来源于盐嗜性芽孢杆菌属李氏菌的抑制发芽的acyloin类化合物litchficin
Md Mehebub Al Raji,Naoya Oku,Agus Trianto et al.
Md Mehebub Al Raji et al.
Litchficin (1), a new acyloin, and three known metabolites, N-succinylanthranilic acid (2), kurasoin A (3), and soraphinol B (4), were isolated from a coral-derived halophilic Gram-positive bacterium, Litchfieldia sp. TUR-22. Compounds 1-4 ...
Olorofim, a potential novel drug candidate against Helicobacter pylori infection [0.03%]
抗幽门螺旋杆菌感染的新型候选药物奥洛夫芬诱导抗菌活性的分子机制研究
Saba Ghaffari,Maryam Esmaeili,Marjan Mohammadi
Saba Ghaffari
Helicobacter pylori infection is widely prevalent and can lead to peptic ulcer disease and gastric cancer. Treatment is challenged by a growing rate of antibiotic resistance. In this study, we evaluated the efficacy of olorofim (F901318), a...
Antibacterial effects of BB-Cl-Amidine against multidrug-resistant Gram-positive pathogens via membrane disruption [0.03%]
膜破坏抗菌剂BB-Cl-Amidine对抗多重耐药革兰氏阳性菌的效果
Zhenfeng Wang,Junhua Ma,Jintuan Lin et al.
Zhenfeng Wang et al.
The escalating prevalence of multidrug-resistant (MDR) gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and linezolid-resistant Enterococcus faecalis, highlights the critical demand for new antibacterial ...
Two novel cytotoxic pyrrole-2,5-dione xylogonone acids A and B isolated from the fungus Xylogone Sphaerospora [0.03%]
来源于真菌Xylogone sphaerospora的两种新型细胞毒性吡咯-2,5-二酮类化合物xylogonone酸A和B
Xiao Ren,Pengran Cao,Jingtong Zhu et al.
Xiao Ren et al.
Two previously unreported compounds, designated pyrrole-2, 5-dione xylogonone acids A (1) and B (2), were isolated from the ascomycete fungus Xylogone Sphaerospora. These metabolites feature a rare, highly functionalized pyrrole-2,5-dione. ...
Correction: Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera [0.03%]
更正：从油茶树叶中分离得到的链霉菌新种——白山茶小单孢子菌（Streptomyces albidocamelliae sp. nov.）
Pei-Lan Long,Jia-Xing Liu,Yan Xiao et al.
Pei-Lan Long et al.
Published Erratum
The Journal of antibiotics. 2025 Oct 3. DOI:10.1038/s41429-025-00867-y 2025
Correction: Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera [0.03%]
更正：从油茶树叶中分离得到的链霉菌新种——Camellia oleifera streptomyces albidocamelliae sp. nov.
Pei-Lan Long,Jia-Xing Liu,Yan Xiao et al.
Pei-Lan Long et al.
Published Erratum
The Journal of antibiotics. 2025 Oct 3. DOI:10.1038/s41429-025-00867-y 2025
Richard E Lee,Minoru Yoshida
Richard E Lee
Linfuranone F, a PPARγ-agonistic furanone-containing polyketide, from a rare actinomycete Sphaerimonospora sp [0.03%]
来自罕见放线菌Sphaerimonosporaspp.的新型PPARγ激动剂并四苯内酯类化合物LinfuranoneF
Desy Wulan Triningsih,Nobuyasu Matsuura,Hisayuki Komaki et al.
Desy Wulan Triningsih et al.
Linfuranone F (1), a new furanone-containing polyketide, was isolated from the culture extract of an actinomycete of the genus Sphaerimonospora along with three known linfuranones B (2), C (3), and D (4). Compound 1 was established as a 6,7...
Genomic and chemical profiling of Botryosphaeria dothidea: cryptic biosynthetic gene clusters and secondary metabolites in agarwood formation [0.03%]
Botryosphaeria dothidea的基因组和化学分析：沉香形成过程中隐藏的次级代谢产物及生物合成基因簇
Xiao-Yan Duan,Dong-Bao Hu,Hataichanok Pandith et al.
Xiao-Yan Duan et al.
This study first integrates genomic and chemical analyses of Botryosphaeria dothidea isolated from Aquilaria sinensis to investigate its role in agarwood formation. Whole-genome sequencing revealed a 44.33 Mb assembly encoding 69 biosynthet...
Antimicrobial activity of triphenylphosphonium (TPP) conjugates of alkynyl-substituted nucleic bases and their analogues [0.03%]
含叠氮取代核苷类似物的三苯基磷
Olga V Andreeva,Alexandra D Voloshina,Anna P Lyubina et al.
Olga V Andreeva et al.
Twenty triphenylphosphonium (TPP) conjugates in which 1-alkynyl-substituted nucleic bases (uracil, thymine) and their analogues (6-methyluracil, quinazoline-2,4-dione) were connected to the TPP cation via an octyl or decyl linker were synth...