Griseolutein T from Streptomyces seoulensis, newly identified via combined-culture with Tsukamurella pulmonis, as an efficacious therapeutic agent against multidrug-resistant bacteria [0.03%]
通过与Tsukamurella pulmonis共培养新发现的链霉菌素seoulensis产生的灰黄霉素T对多药耐药细菌具有有效的治疗作用
Sung-Jin Kawai,Shumpei Asamizu,Hiroaki Suzuki et al.
Sung-Jin Kawai et al.
Bacterial interactions can affect the production of secondary metabolites and, therefore, provide a promising approach to exploring new microbial compounds. In this study, we screened actinomycetes isolated from Hegura Island, Ishikawa Pref...
Evieann Cardoza,Darsh Vira,Advait Rao et al.
Evieann Cardoza et al.
Stressors like translational inhibitors stall protein synthesis and produce a response specific to temperature extremes. Yet, little is known about the expression of temperature-related proteins, particularly the cold shock proteins (Csps),...
Alicia M Gutiérrez-Mauricio,Juan Valentín Trujillo-Paez,Luis Alberto Trejo-Martinez et al.
Alicia M Gutiérrez-Mauricio et al.
Tuberculosis (TB) is a contagious infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). It is transmitted through small particles in the air (
Isolation and structure determination of streptospherins B-F, novel cancer stem cell inhibitors, produced by Streptomyces sp. KUSC-240 [0.03%]
链霉菌KUSC-240产生的新型癌症干细胞抑制剂streptospherin B-F的分离及结构鉴定
Morihiro Shibasaki,Hiroaki Ikeda,Ami Mimura et al.
Morihiro Shibasaki et al.
Streptospherin A (1), which has pentasubstituted benzene and tetrahydropyran moieties, was recently isolated in our laboratory from Streptomyces sp. KUSC-240 as a novel inhibitor of cancer stem cell (CSC) sphere formation. Given the potenti...
Study about fluostatins: efficient preparation of fluostatin A and discovery of fluostatin derivatives from Streptomyces sp. TA-3391 [0.03%]
关于fluostatins的研究：TA-3391产链霉菌中高效合成化合物fluostatin A及其衍生物发现
Shigehiro Tohyama,Seiji Nukui,Masaki Hatano et al.
Shigehiro Tohyama et al.
Fluostatins are a class of compounds having four unique ring systems. They were originally isolated as dipeptidyl peptidase III (DPP3) inhibitors, and various derivatives and activities have been reported. In this study, fluostatin A, which...
Correction: Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model [0.03%]
有关左氟沙星浓度对空心纤维感染模型中肺炎链球菌的评价的更正通知
Haruka Nakagawa Kamura,Tetsuo Yamaguchi,Toshihiro Kasama et al.
Haruka Nakagawa Kamura et al.
Published Erratum
The Journal of antibiotics. 2025 Jun 16. DOI:10.1038/s41429-025-00837-4 2025
Rare distribution of butenolide-type signaling molecules among Streptomyces strains and functional importance as inducing factors for secondary metabolite production in Streptomyces rochei 7434AN4 [0.03%]
土霉素产生菌链霉菌ROCHEI 7434AN4中布泰内酸型信号分子的分布及诱导活性研究
Asahi Hirata,Miho Sumiyoshi,Hazuki Fujita et al.
Asahi Hirata et al.
Streptomyces rochei 7434AN4 produces two structurally unrelated polyketide antibiotics, lankacidin (LC) and lankamycin (LM), and their biosynthesis is tightly controlled by 2,3-disubstituted butenolide-type signaling molecules SRB1 and SRB2...
Micrococcins from Peribacillus sp. KDM594; efficacy against vancomycin-resistant enterococci and drug metabolism in a silkworm model [0.03%]
KDM594分枝杆菌微球菌素的产生及其对耐万古霉素肠球菌的有效性以及蚕模型中的药物代谢研究
Akiho Yagi,Mayu Sato,Katsuki Kikuchi et al.
Akiho Yagi et al.
The screening of antibiotics derived from microbial resources to combat vancomycin-resistant enterococci (VRE) revealed that a culture of marine-derived Peribacillus sp. KDM594 exhibited significant therapeutic efficacy in an infected in vi...
New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82 [0.03%]
由深海可可毛霉菌LW82分离得到的新型抗菌并四苯醇类化合物
Yu Tu,Jinxin Zhang,Lei Cai et al.
Yu Tu et al.
Two new butanolides asperbutanolides A (1) and B (2), and a new fatty acid derivative omphalotol C (3), along with 5 known compounds were isolated from the ethyl acetate (EtOAc) crude extract of the deep-sea-derived fungus Aspergillus tabac...
Ólafur S Andrésson,Douglas E Berg,Patrice Courvalin et al.
Ólafur S Andrésson et al.