Genomic and chemical profiling of Botryosphaeria dothidea: cryptic biosynthetic gene clusters and secondary metabolites in agarwood formation [0.03%]
Botryosphaeria dothidea的基因组和化学分析：沉香形成过程中隐藏的次级代谢产物及生物合成基因簇
Xiao-Yan Duan,Dong-Bao Hu,Hataichanok Pandith et al.
Xiao-Yan Duan et al.
This study first integrates genomic and chemical analyses of Botryosphaeria dothidea isolated from Aquilaria sinensis to investigate its role in agarwood formation. Whole-genome sequencing revealed a 44.33 Mb assembly encoding 69 biosynthet...
Antimicrobial activity of triphenylphosphonium (TPP) conjugates of alkynyl-substituted nucleic bases and their analogues [0.03%]
含叠氮取代核苷类似物的三苯基磷
Olga V Andreeva,Alexandra D Voloshina,Anna P Lyubina et al.
Olga V Andreeva et al.
Twenty triphenylphosphonium (TPP) conjugates in which 1-alkynyl-substituted nucleic bases (uracil, thymine) and their analogues (6-methyluracil, quinazoline-2,4-dione) were connected to the TPP cation via an octyl or decyl linker were synth...
The mechanisms of antibiotic resistance and drug resistance transmission of Klebsiella pneumoniae [0.03%]
肺炎克雷伯菌抗生素和药物耐药性机制及耐药传播研究进展
Shuai Zheng,Shuang Li,Duo Zhang et al.
Shuai Zheng et al.
Klebsiella pneumoniae is a ubiquitous Gram-negative pathogen in clinical settings, responsible for pulmonary infections, urinary tract infections, septicemia, and other severe diseases.Over recent years, widespread use of aminoglycosides, q...
Amycolatopsis cyclosori sp. nov., isolated from the rhizosphere soil of Cyclosorus parasiticus [0.03%]
芽孢杆菌科环里白苞菌素亚属新种 Amycolatopsis cyclosori 的分类学描述
Ya-Zi Chen,Rong-Jian Gao,Ming-Yue Li et al.
Ya-Zi Chen et al.
A novel actinomycete strain, cg5T, was isolated from the rhizosphere soil of Cyclosorus parasiticus, collected from Xiangtan City, Hunan province, China. Strain cg5T contained meso-diaminopimelic acid as a diagnostic amino acid. Whole-cell ...
Strategic design of a multi-tier database for class A β-lactamase BlaC variants of M. tuberculosis: advancing the fight against antibacterial resistance [0.03%]
分层数据库的策略设计：针对结核分支杆菌A类β-内酰胺酶BlaC变异体的抗细菌耐药性斗争中的应用与发展
K C Ananth Kumar,Adwaita Nair,Shreya Sharma et al.
K C Ananth Kumar et al.
The escalating rise of antimicrobial resistance (AMR) casts a grave shadow over global public health, making once manageable infections increasingly difficult to treat. Despite advancements in combination chemotherapy for multidrug-resistan...
A new glycosylated derivative of rausuquinone with cytotoxic activity from Streptomyces sp. HU061-2 [0.03%]
一种具细胞毒性的链霉菌HU061-2代谢产物拉索酮糖苷及其制备方法和应用
Ping-Ting Qian,Zhen-Yu Wang,Xiao-He Jia et al.
Ping-Ting Qian et al.
A new glycosylated derivative of rausuquinone, rausuquinonoside (1), was isolated from the Tai Lake sediment-derived actinomycete, Streptomyces sp. HU061-2. The structure of 1 was determined by 1D, 2D NMR, MS spectral analysis and the compa...
Mutactimycins H-J, antimycobacterial anthracyclines, from a thermophilic actinomycete of the genus Gandjariella [0.03%]
来源于热嗜杆菌属Gandjariella的抗分枝杆菌类蒽环素类抗生素mutactimycins H-J
Desy Wulan Triningsih,Satsuki Kimachi,Fitria Ningsih et al.
Desy Wulan Triningsih et al.
Chemical studies of Gandjariella species from geothermal soil led to the isolation of three new glycosylated anthracyclines, mutactimycins H-J (1-3), along with known mutactimycin E (4). The structures of 1-3 were elucidated by combination ...
Gold nanoparticles functionalised with vancomycin enhance antibacterial activity and inhibit Streptococcus pneumoniae adherence and invasion in alveolar cells [0.03%]
表面修饰万古霉素的金纳米颗粒可增强抗菌活性并抑制肺炎链球菌黏附和侵袭肺泡细胞
Edgar Augusto Ortiz-Benitez,Diego Jeovani Huerta-Flores,Norma Velázquez-Guadarrama et al.
Edgar Augusto Ortiz-Benitez et al.
Streptococcus pneumoniae (S. pneumoniae) is a leading cause of respiratory infections, with increasing antibiotic resistance posing a major challenge. While gold nanoparticles (AuNPs) functionalised with antibiotics have been explored, thei...
Streptomyces cyclosori sp. nov., a novel actinobacterium from the rhizosphere soil of Cyclosorus parasiticus (L.) Farw [0.03%]
芽孢柄杆菌新种 Streptomyces cyclosori sp. nov. ，分离自铁线蕨 Cyclosorus parasiticus （ L .） Farw 的根际土壤
Rongjian Gao,Yazi Chen,Yan Xiao et al.
Rongjian Gao et al.
A novel actinobacterium strain cg36T, from the rhizosphere of Cyclosorus parasiticus, was subjected to a polyphasic taxonomic study. 16S rRNA gene sequence analysis showed that strain cg36T shared the highest 16S rRNA gene sequence similari...
Kaempferol inhibits lipid accumulation in alcoholic fatty liver disease through PRMT-1-mediated arginine methylation of SCD1 [0.03%]
芸香苷通过PRMT1介导的精氨酸甲基化抑制SCD1在酒精性脂肪肝病中的作用
Jiahui Li,Zheng Zhou,Qiaoling Zhou
Jiahui Li
Alcoholic fatty liver disease (AFLD) is a type of liver damage caused by excessive alcohol consumption. Kaempferol (Kae) has been shown to have good anti-cancer effects. This study aimed to investigate the effect and the mechanism of Kae on...