Structure-activity relationship studies of ME1111, a novel antifungal agent for topical treatment of onychomycosis [0.03%]
甲襞真菌病治疗的新型抗真菌剂ME1111的构效关系研究
Naomi Takei-Masuda,Maiko Iida,Makoto Ohyama et al.
Naomi Takei-Masuda et al.
Onychomycosis is a prevalent disease in many areas of the world, affecting approximately 5.5% of the global population. Among several subtypes of onychomycosis, distal-lateral-subungual onychomycosis is the most common, and topical onychomy...
Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems [0.03%]
基于蚕活体筛选系统的新抗菌药物（AMR）的发现及其作用于抗菌活性调节因子模式的研究
Fumiaki Tabuchi,Kazuhiro Mikami,Masanobu Miyauchi et al.
Fumiaki Tabuchi et al.
Global concerns about drug-resistant bacteria have underscored the need for new antimicrobial drugs. Emerging strategies in drug discovery include considering the third factors that influence drug activity. These factors include host-derive...
Antimicrobial activity of α/β hybrid peptides incorporating tBu-β3,3Ac6c against methicillin-resistant Staphylococcus aureus [0.03%]
含tBu-β3,3Ac6c的α/β杂合肽对耐甲氧西林金黄色葡萄球菌的抗菌活性
Aminur Rahman Sarkar,Jyoti Kumari,Arti Rathore et al.
Aminur Rahman Sarkar et al.
The incorporation of β-amino acids into peptides is a promising approach to develop proteolytically stable therapeutic agents. Short α/β hybrid peptides containing tBu-β3,3Ac6cː H2N-Lys-tBu-β3,3Ac6c-PEA, P1; H2N-Orn-tBu-β3,3Ac6c-PEA,...
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6 [0.03%]
来源于地衣芽孢杆菌MM794L-181F6的新的噻唑肽类抗生素茋氨霉素
Yasuhiro Takehana,Hideyuki Muramatsu,Masaki Hatano et al.
Yasuhiro Takehana et al.
A new bioactive substance was identified from a leaf-litter actinomycete strain by screening for antibacterial activity against Neisseria gonorrhoeae. The thiazolyl peptide antibiotic, named thiazoplanomicin, was isolated from the secondary...
Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222 [0.03%]
来源于海洋真菌Simplicilliumsp. SCSIO 41222的新肽Sinulariapeptide F
Yan-Chun He,Meng-Qin Wang,Qing-Qing Tie et al.
Yan-Chun He et al.
One new compound named sinulariapeptide F (1) together with one known butyrolactone (2) and seven known peptides (3-9) were isolated from the fungus Simplicillium sp. SCSIO 41222. Their structures and absolute configurations were establishe...
Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge [0.03%]
芽子链霉菌阪东亚种新型伯尼南霉素产生放线菌海绵来源细菌分类学研究
Miku Takahashi,Kanata Hoshino,Moriyuki Hamada et al.
Miku Takahashi et al.
While screening for antibiotics in a marine sample, we discovered a berninamycin C-producing actinomycete, designated YSPA8T, isolated from a sponge. A polyphasic approach was used to determine the taxonomic position of the strain. Strain Y...
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes [0.03%]
金黄色葡萄球菌耐利福霉素的产生机制：突变、修饰和基因获取
Wenjing Yang,Taoran Chen,Qi Zhou et al.
Wenjing Yang et al.
Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the formation of the initiation complex. Oxazolidinone antimicrobial drugs represent the last line of defense in treating Sta...
Alexander D H Kingdon,Holly V Adcock,Eleni-Marina Kasimati et al.
Alexander D H Kingdon et al.
Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuberculosis infections. The complex treatment regimen required to treat tuberculosis and growing rates of drug resistance,...
Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins [0.03%]
关于3',6'-取代光神菌素的合成及抗菌活性的更正：分子细菌学杂誌10.1002/bmb.1869的研究论文
Suresh Dharuman,Gregory A Phelps,Christine M Dunn et al.
Suresh Dharuman et al.
Published Erratum
The Journal of antibiotics. 2024 Oct 11. DOI:10.1038/s41429-024-00777-5 2024
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase [0.03%]
巴弗一号菌Aspergillus insuetus BF-1613产生的角鲨烯序三萜酯类化合物及其作为卵泡刺激素的竞争性抑制剂的作用机制研究
Elyza Aiman Azizah Nur,Keisuke Kobayashi,Rio Tejima et al.
Elyza Aiman Azizah Nur et al.
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses...