Cycloimidamicins, Novel natural lead compounds for translation inhibition in Pseudomonas aeruginosa [0.03%]
新的环酰胺类次级代谢产物通过抑制翻译发挥抗绿脓杆菌活性
Yoshimasa Ishizaki,Maya Umekita,Rie Arisaka et al.
Yoshimasa Ishizaki et al.
Pseudomonas aeruginosa is one of the most concerning pathogenic bacteria. We screened antibiotics using a highly drug-sensitive P. aeruginosa strain and an oligotrophic medium, and successfully isolated novel antibiotics, namely cycloimidam...
A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921 [0.03%]
由真菌Synnemellisiasp.FKR-0921产生的一种新型芳香族化合物
Arisu Tahara,Kazuki Tani,Miyu Wakatsuki et al.
Arisu Tahara et al.
The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The st...
When less is more: shortening the Lpp protein leads to increased vancomycin resistance in Escherichia coli [0.03%]
量少作用大：在大肠杆菌中缩短Lpp蛋白可以增强万古霉素抗性
Hannah Wykes,Vuong Van Hung Le,Catrina Olivera et al.
Hannah Wykes et al.
Vancomycin is a naturally occurring cell-wall-targeting glycopeptide antibiotic. Due to the low potency of this antibiotic against Gram-negative pathogens, such as Escherichia coli, there is a limited knowledge about interactions between va...
Pullusurfactins A‒C, new biosurfactants produced by Aureobasidium pullulans A11231-1-58 from Chrysanthemum boreale Makino [0.03%]
来源于小黄花的产胶型隐球菌A11231-1-58产生的新型生物表面活性剂pullusurfactins A‒C
Jong-Shik Kim,Dae-Won Ki,In-Kyoung Lee et al.
Jong-Shik Kim et al.
Biosurfactants have found widespread use across multiple industrial fields, including medicine, food, cosmetics, detergents, pulp, and paper, as well as the degradation of oil and fat. The culture broth of Aureobasidium pullulans A11231-1-5...
Correction: New piericidin rhamnosides as potentiators of amphotericin B activity against Candida albicans produced by actinomycete strain TMPU-A0287 [0.03%]
订正：产生新型球紫堇素鼠李糖苷提高TMPU-A0287链霉菌对光滑念珠菌活性的两性霉素B抗生素
Akiho Yagi,Yuga Yamaguchi,Keiko Kawasaki et al.
Akiho Yagi et al.
Published Erratum
The Journal of antibiotics. 2023 Nov;76(11):689. DOI:10.1038/s41429-023-00654-7 2023
Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae [0.03%]
来自Herpotrichiellaceae菌株的抗疟药环状五肽 Sheptide A
Robert A Shepherd,Cody E Earp,Kristof B Cank et al.
Robert A Shepherd et al.
As part of ongoing efforts to isolate biologically active fungal metabolites, a cyclic pentapeptide, sheptide A (1), was discovered from strain MSX53339 (Herpotrichiellaceae). The structure and sequence of 1 were determined primarily by ana...
Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8 [0.03%]
由产自海洋的链霉菌新型22元内酰胺类大环抗生素哈尼霉素生成菌KM77-8产生的一种哈尼霉素成分
Moeka Uemura,Keisuke Kobayashi,Noriko Sato et al.
Moeka Uemura et al.
A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a n...
Botryorhodines K and L, two new cytotoxic depsidones from a fungus of the genus Arcopilus [0.03%]
来自弧皮伞属真菌的两个新的细胞毒性的 depsidones 类化合物BOTRYORHODINES K和L
Zhiwei Zhang,Yiwei Ge,Yasuko In et al.
Zhiwei Zhang et al.
Botryorhodines K (1) and L (2), two new depsidone derivatives, along with one known metabolite, 4-O-demethylbarbatic acid (3), were isolated from the culture extract of a fungus of the genus Arcopilus. The structures of 1‒3 were determined...
Aspects for development of novel antibacterial medicines using a vitamin D3 decomposition product in Helicobacter pylori infection [0.03%]
用于Helicobacter pylori感染的新型抗生素维生素D3分解产物的发展方面
Kiyofumi Wanibuchi,Kouichi Hosoda,Avarzed Amgalanbaatar et al.
Kiyofumi Wanibuchi et al.
A previous study by our group demonstrated that a vitamin D3 decomposition product (VDP1) acts as the selective bactericidal substance on Helicobacter pylori. VDP1 is an indene compound modified with a carbonyl and an alkyl. The alkyl of VD...
Antibiotic stewardship programs should include disinfectants and biocides [0.03%]
抗生素管理项目应纳入消毒剂和生物杀菌剂
Prabhavathi Fernandes
Prabhavathi Fernandes