Anti-microbial efficacy of L-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection [0.03%]
L-谷氨酰胺酶（EC 3.5.1.2）对抗多重耐药绿脓杆菌感染的抗菌效果研究
Likaa H Mahdi,Buthenia A Hasoon,Ghassan M Sulaiman et al.
Likaa H Mahdi et al.
The aims of this study were isolation-purification and characterization of L-glutaminase from L. gasseri BRLHM clinical isolates and investigation of its efficiency as an antimicrobial agent against multidrug-resistant P. aeruginosa. The MI...
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7 [0.03%]
海洋链霉菌新倍他拉唑衍生物抗菌乙肝病毒成分分子杂环化物 катенулопиризомицины, 新的抗乙肝病毒化合物, 来源于罕见放线菌属链霉菌物种 MM782L-181F7
Manabu Yamasaki,Ryuichi Sawa,Hideyuki Muramatsu et al.
Manabu Yamasaki et al.
Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections. To improve the treatment efficacy, novel therapeutic agents, especially those with different mechanisms of action, ne...
Retraction Note: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium [0.03%]
撤回 notice: 喹诺酮类药物类衍生物的分子对接模拟、类药性评价及药代动力学研究针对副溶血弧菌DNA促旋酶与拓扑异构酶 IV
Philip John Ameji,Adamu Uzairu,Gideon Adamu Shallangwa et al.
Philip John Ameji et al.
Retraction of Publication
The Journal of antibiotics. 2024 Feb;77(2):128. DOI:10.1038/s41429-023-00684-1 2024
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells [0.03%]
两种新的腺肽B和C可抑制胰腺癌细胞的球状体形成
Daisuke Tatsuda,Masahide Amemiya,Chisato Nosaka et al.
Daisuke Tatsuda et al.
Cancer remains one of the leading causes of death worldwide, particularly pancreatic cancer being lethal because of its aggressiveness and lack of early detection methods. A factor that contributes to malignancy are cancer stem cell-like ch...
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1 [0.03%]
评估A环羟基亚氨三萜类化合物作为SARS-CoV-2刺突假病毒和流感H1N1的抑制剂的效果
Oxana Kazakova,Xinyuan Ma,Elena Tretyakova et al.
Oxana Kazakova et al.
A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and...
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target [0.03%]
染色质修饰蛋白4C(CHMP4C)作为潜在的乳腺癌治疗靶点影响乳腺癌细胞增殖和多柔比星抗性
Xiaoyan Jin,Jian Wang,Zhengyi Wang et al.
Xiaoyan Jin et al.
Breast cancer (BCa) is one of the common malignancies among women. Doxorubicin (Dox), a type of anthracycline anti-tumor drug, is a first-line chemotherapy drug for BCa. It is badly needed to effectively reverse BCa resistance to Dox and im...
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551 [0.03%]
来自内生真菌Pestalotiopsis trachicarpicola SC-J551的生物活性ambuic酸同类物
Fanyu Dong,Zhiming Jiang,Ping Wu et al.
Fanyu Dong et al.
New ambuic acid derivatives, pestallic acids R-V (1-5), together with ambuic acid (6), were isolated from the endophytic fungus Pestalotiopsis trachicarpicola SC-J551 derived from the fern Blechnum orientale L., of which compound 2, being r...
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784 [0.03%]
来自Kitasatospora sp. LS1784阻断铜绿假单胞菌感染的铁载体的鉴定
Baosong Chen,Yue Wang,Feng Xie et al.
Baosong Chen et al.
Siderophores are low-molecular-mass, high-affinity chelators of Fe3+ ions that are critical for the survival of bacteria in ferric deficient environment. Exogenous siderophores are potential bacteriostat by disrupting the iron-uptake proces...
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation [0.03%]
Notch激活剂环孢酸原酸通过活化钙调神经磷酸酶诱导HL-60细胞凋亡
Shiina Suzuki,Shun Saito,Yuki Narushima et al.
Shiina Suzuki et al.
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F (1) and G (2), and cyclopiazonic acid (CPA) (3) as Notch activators. Pulicatin F (1) and (±)-pulicatin G were synthe...
Correction: Antibiotics in the clinical pipeline as of December 2022 [0.03%]
纠正：2022年12月临床抗生素pipeline中的抗生素
Mark S Butler,Ian R Henderson,Robert J Capon et al.
Mark S Butler et al.
Published Erratum
The Journal of antibiotics. 2024 Jan;77(1):71. DOI:10.1038/s41429-023-00671-6 2024