Biosynthesis of antibiotics with sulfonamide and azaindane moieties [0.03%]
具有磺酰胺和氮杂吲哚结构的抗生素生物合成机制研究
Takayoshi Awakawa
Takayoshi Awakawa
As research into the biosynthesis of natural products has matured, the biosynthetic pathways of common skeletons have been identified one after another, and attention is now being focused on research into the biosynthetic machineries of com...
Terramide A: a novel ironophore targeting Acinetobacter baumannii with mechanistic insights into bacterial iron deprivation [0.03%]
特里胺酰胺A：一种针对鲍曼不动杆菌的新型铁载体，并对其细菌缺铁机制进行了探讨
Hanxiang Jiang,Jiangfeng Qi,Jiwen Wang et al.
Hanxiang Jiang et al.
Acetobacter baumannii poses escalating clinical challenges due to its exceptional adaptability, demanding innovative antimicrobial strategies. This study pioneers an investigation into the antibacterial efficacy and molecular mechanism of T...
Kodai Machida,Shotaro Noseda,Seraya Miki et al.
Kodai Machida et al.
Sporogen-AO1, a sporulation-promoting substance of Aspergillus oryzae was found to be a nonspecific translation inhibitor during screening of 22400 compounds. Sporogen-AO1 inhibited protein synthesis in cell-free protein synthesis (CFPS) sy...
Bioactive hydrogenated azaphilones from acid-tolerant fungus Penicillium purpureum OUCMDZ-019 [0.03%]
耐酸青霉菌(OUCMDZ-019)中的生物活性氢化氮芬酮
Chengfeng Hou,Yuqing Wang,Xiangling Meng et al.
Chengfeng Hou et al.
Two new hydrogenated azaphilones (1 and 2), together with the known azaphilone (3) were isolated from the red soil-derived acid-tolerant fungus Penicillium purpureum OUCMDZ-019 by OSMAC (one strain many compounds) strategy. Their structures...
Correction: New potentiators of amphotericin B activity, shodoamides A to C produced by Pseudophialophora sp. BF-0158 [0.03%]
修正：Pseudophialophora 属BF-0158 strain 产生的新型两面针胺类化合物（Shodoamide A到C）可增强两性霉素B的活性
Akiho Yagi,Masahiro Kashima,Hiroyuki Ishijima et al.
Akiho Yagi et al.
Published Erratum
The Journal of antibiotics. 2025 Mar 13. DOI:10.1038/s41429-025-00814-x 2025
Epiconone, one novel cyclohexenone from endophytic fungi Epicoccum sp. 1-042 [0.03%]
内生真菌Epicoccum sp. 1-042的一个新颖的环己烯酮类化合物——epiconone
Shanshan Chang,Xinyue Huang,Meng Liu et al.
Shanshan Chang et al.
Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet. Bioassay-guided isolation from Epicoccum sp. 1-042 yielded a novel cycl...
The thiodiketopiperazine derivatives shovelmycin A-B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001 [0.03%]
冷泉来源的链霉菌Streptomyces olivaceus HDN22-001中的硫代二酮哌嗪衍生物shovelmycin A-B和ansamycin衍生物divergolide X
Chen Li,Jiangli Cheng,Ruojin Liu et al.
Chen Li et al.
Three new compounds including two thiodiketopiperazine derivatives shovelmycins A-B (1-2), and one ansamycin derivative divergolide X (3) were isolated and identified from the culture extract of Streptomyces olivaceus HDN22-001, a marine ac...
The secondary metabolites of the alga-derived fungus Aspergillus niveoglaucus КММ 4176 and their antimicrobial and antibiofilm activities [0.03%]
来源于藻类的曲霉Aspergillus niveoglaucus КММ 4176的次级代谢物及其抗微生物和抗生物膜活性
Nadezhda P Shlyk,Ekaterina A Yurchenko,Elena V Leshchenko et al.
Nadezhda P Shlyk et al.
Marine alga-derived fungal strain КММ 4176 was identified as Aspergillus niveoglaucus based on ITS region BenA, CaM and RPB2 gene sequence analysis. The anthraquinone derivatives emodin anthrone (1) and 4-hydroxyemodin anthrone (2), chro...
Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii [0.03%]
来自蝎毒的蓝色苯醌对优先病原菌鲍曼不动杆的耐药株具有杀菌活性
Ramses Gallegos-Monterrosa,Jimena I Cid-Uribe,Gustavo Delgado-Prudencio et al.
Ramses Gallegos-Monterrosa et al.
Antibiotic-resistant bacteria pose a significant global health threat, particularly pathogens resistant to last-resort antibiotics, such as those listed as priority pathogens by the World Health Organization. Addressing this challenge requi...
Streptomyces tabacisoli sp. nov, isolated from the rhizosphere soil of Nicotiana tabacum [0.03%]
烟草根际土壤中一新种链霉菌streptomycestabacisoli
Kaiqin Li,Hao Zhang,Ying Qian et al.
Kaiqin Li et al.
Strain HUAS MG91T, a novel actinobacterium, was isolated from the rhizosphere soil of Nicotiana tabacum collected from Changde City, China. This strain could form short, rod-shaped spores with a smooth surface and Rectiflexibles spore chain...