Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058 [0.03%]
由FKI-8058 Apiospora产生新的pramanicin类似物——Virgaricins C和D
So-Ichiro Kimura,Yoshihiro Watanabe,Yudai Mikasa et al.
So-Ichiro Kimura et al.
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical deri...
Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086 [0.03%]
来自海洋诺卡式菌株HDN154086的抗菌p-三联苯和α-吡喃衍生物
Luning Zhou,Yimin Chang,Shengkuan Yang et al.
Luning Zhou et al.
Assisted by OSMAC strategy, one new p-terphenyl and two new α‑pyrone derivates, namely nocarterphenyl I (1) and nocardiopyrone D-E (2-3), were obtained and characterized from the marine sediment-derived actinomycete Nocardiopsis sp. HDN15...
Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity [0.03%]
红天层肽衍生物的合成及其作为两性霉素B活性增强子的生物活性评价
Kenichiro Nagai,Keisuke Kobayashi,Ryosuke Miyake et al.
Kenichiro Nagai et al.
Nectriatide 1a, a naturally occurring cyclic tetrapeptide, has been reported to a potentiator of amphotericin B (AmB) activity. In order to elucidate its structure-activity relationships, we synthesized nectriatide derivatives with differen...
Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid [0.03%]
含有吡咯烷酸的新三肽素C类似物三肽素Cpip的前体定向生物合成及其生物活性
Hideki Hashizume,Ryuichi Sawa,Yumiko Kubota et al.
Hideki Hashizume et al.
Tripropeptin C, a non-ribosomal cyclic lipopeptide containing three proline residues, exhibits excellent efficacy in the mouse-methicillin-resistant Staphylococcus aureus septicemia model. Since tripropeptins contain L-prolyl-D-proline and,...
Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts [0.03%]
基于质谱指导从Setosphaeria rostrata培养介质的乙酸乙酯提取物中分离硫代二酮哌嗪及其对TNF-α诱导的人皮肤成纤维细胞抗皮肤老化的影响
Haeun Kwon,Hee Woon Ann,Sojung Park et al.
Haeun Kwon et al.
Using mass spectrometry (MS)-guided isolation methods, a new thiodiketopiperazine derivative (1) and exserohilone (2) were isolated from an EtOAc-extract of Setosphaeria rostrata culture medium. The chemical structure of the new compound wa...
The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model [0.03%]
TunR2（一种链霉毒素衍生物）在体内海马分枝杆菌斑马鱼感染模型中展现出强大的低毒抗生素性能
Hannah J T Nonarath,Michael A Jackson,Renee M Penoske et al.
Hannah J T Nonarath et al.
Tunicamycins (TUN) are well-defined, Streptomyces-derived natural products that inhibit protein N-glycosylation in eukaryotes, and by a conserved mechanism also block bacterial cell wall biosynthesis. TUN inhibits the polyprenylphosphate-N-...
Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis [0.03%]
以PRRP为中心轴的高治疗指数抗菌肽的设计、生物特性和抗菌机制
Shuang Yu,Boyan Jia,Ying Zhang et al.
Shuang Yu et al.
As the important components of biological innate immunity, antimicrobial peptides (AMPs) were found in a variety of organisms including insects, plants, animals, bacteria, fungi, etc. However, high hemolytic activity, high toxicity, and poo...
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity [0.03%]
半合成及结构活性关系研究产生低细胞毒性的抗菌vicenistatin衍生物
Jun Li,Zhenye Yang,Chuanling Shi et al.
Jun Li et al.
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In this study, to further explore the potential of 1 as candidates of antibacterial drug development, 4'-N-demethyl vice...
Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499 [0.03%]
深海真菌Scedosporium apiospermum FKJ-0499产生的酪醇茋及其新类似物对耳念珠菌临床分离株的抗真菌谱研究
Haruki Azami,Yoshihiro Watanabe,Kazunari Sakai et al.
Haruki Azami et al.
A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2...
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13 [0.03%]
来自放线菌Kitasatospora putterlickiae 10-13的新型抗生素生物合成前体precezomycin
Di Mao,Pengwei Yu,Naoya Shinzato et al.
Di Mao et al.
A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinomycete Kitasatospora putterlickiae 10-13. The planar structure was determined by 1D/2D NMR and HR(ESI)MS data analyses,...