Kyriacos C Nicolaou,Stephan Rigol
Kyriacos C Nicolaou
The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes. And yet despite our powerful arsenal of we...
Effect of the meropenem MIC on the killing activity of meropenem and polymyxin B in combination against KPC-producing Klebsiella pneumoniae [0.03%]
美罗培南MIC值对联合多粘菌素B杀灭携带KPC酶肺炎克雷伯菌的活性影响
Brandon Kulengowski,Jeffrey J Campion,David J Feola et al.
Brandon Kulengowski et al.
A 2,4'-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp [0.03%]
一种具有蛋白酪氨酸磷酸酶1B抑制活性的新的2，4’-联接四羟基查耳酮二聚体化合物
Henki Rotinsulu,Hiroyuki Yamazaki,Tomohito Miura et al.
Henki Rotinsulu et al.
Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity [0.03%]
一种新型具有较低肾毒性的氨基糖苷类抗生素--2-羟基arbekacin的发现
Yoshiaki Takahashi,Eijiro Umemura,Yoshihiko Kobayashi et al.
Yoshiaki Takahashi et al.
Coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation [0.03%]
肉豆蔻-苯并咪唑杂化物作为抗菌剂的研究合成及生物活性研究
L Ravithej Singh,Srinivasa Rao Avula,Sneha Raj et al.
L Ravithej Singh et al.
Molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. A novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad...
A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids [0.03%]
ACE环结构的C19倍半萜类生物碱的三组分偶联合成方法学研究
Kosuke Minagawa,Daisuke Urabe,Masayuki Inoue
Kosuke Minagawa
C19-diterpene alkaloids are a class of alkaloids with pharmacologically important activities having an intricately fused hexacyclic ABCDEF-ring system. Here we report expeditious assembly of the ACE-ring substructure 4a by applying a three-...
Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2-p53 complex formation [0.03%]
抗菌磺胺类药物清除潜在的卡波西肉瘤疱疹病毒并破坏MDM2-p53复合物形成
Fabrizio Angius,Enrica Piras,Sabrina Uda et al.
Fabrizio Angius et al.
Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8, is the causative agent of Kaposi sarcoma; this malignant angiosarcoma is usually treated with conventional antitumor agents that can control disease evolution, but do not...
Comparative Study
The Journal of antibiotics. 2017 Aug;70(9):962-966. DOI:10.1038/ja.2017.67 2017
Albiducins A and B, salicylaldehyde antibiotics from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus [0.03%]
来自与灰芽子菌Hymenoscyphus albidus相关腐生真菌的水杨醛抗生素Albiducin A和B
Sandra Halecker,Frank Surup,Halvor Solheim et al.
Sandra Halecker et al.
The salicylidene acylhydrazide INP0341 attenuates Pseudomonas aeruginosa virulence in vitro and in vivo [0.03%]
一种水杨醛缩胺类化合物INP0341通过抑制铜绿假单胞菌毒力而发挥体内外抗菌活性
Pia Uusitalo,Ulrik Hägglund,Elin Rhöös et al.
Pia Uusitalo et al.
Pseudomonas aeruginosa is an opportunistic pathogen that can be very hard to treat because of high resistance to different antibiotics and alternative treatment regimens are greatly needed. An alternative or a complement to traditional anti...
D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus [0.03%]
D-环丝氨酸可增强万古霉素对高万古霉素耐药金黄色葡萄球菌的作用
Fumiaki Tabuchi,Yasuhiko Matsumoto,Masaki Ishii et al.
Fumiaki Tabuchi et al.
Vancomycin is a widely used clinical drug to treat for infection by methicillin-resistant Staphylococcus aureus. Some patients show a weak response to vancomycin treatment. We previously reported that β-lactams increase the susceptibility ...
Comparative Study
The Journal of antibiotics. 2017 Jul;70(8):907-910. DOI:10.1038/ja.2017.56 2017