Biosynthesis of macrolactam antibiotics with β-amino acid polyketide starter units [0.03%]
以β-氨基酸聚酮化合物起始单元的巨抗生素生物合成
Fumitaka Kudo
Fumitaka Kudo
Macrolactam antibiotics incorporating β-amino acid polyketide starter units, isolated primarily from Actinomycetes species, show significant biological activities. This review provides a detailed analysis into the biosynthetic studies of v...
Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793 [0.03%]
由放线菌JCM 4793产生的具有细胞毒活性的戊二酰亚胺类聚酮类化合物
Lin-Fang Tang,Wu-Lai Jihuo,Pei-Dong Shi et al.
Lin-Fang Tang et al.
Glutarimide-containing polyketides usually exhibit anti-fungi activity, which was well exampled by cycloheximide. In our work, three new polyketide structures, 12-amidestreptimidone (1), 12-carboxylstreptimidone (2) and 3-(5S,8R)-(2-amino-2...
Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp [0.03%]
一种新的来源于Talaromyces种丝状真菌的ALA-连接聚酮类化合物的分离鉴定及其抗病毒活性研究
Nozomi Mosu,Mitsuki Yasukochi,Shogo Nakajima et al.
Nozomi Mosu et al.
Antiviral agents are highly sought after. In this study, a novel alkylated decalin-type polyketide, alaspelunin, was isolated from the culture broth of the fungus Talaromyces speluncarum FMR 16671, and its structure was determined using spe...
Streptomyces chengbuensis sp. nov., isolated from the rhizosphere soil of Cathaya argyrophylla [0.03%]
解聚糖链霉菌新型链霉菌种模式菌株保藏号CGMCC No.10472英文名Streptomyces chengbuensis sp. nov.
Yaxi Zheng,Ping Mo,Chenxi Li et al.
Yaxi Zheng et al.
Strain HUAS CB01T was a novel actinobacterium which was isolated from the rhizosphere soil of Cathaya argyrophylla, Chengbu Miao Autonomous County of Hunan Province, China. The strain formed well-growing substrate mycelium, diffusible pigme...
Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor [0.03%]
糖环素L的逆氮杂迈克尔反应机制研究：确定2-氨基-4-甲基苯酚为有效的迈克尔受体保护工具
Shan Lu,Lingling Ren,Di Mao et al.
Shan Lu et al.
Saccharothriolide L (1), a derivative of saccharothriolides (STLs) produced by the rare actinomycete Saccharotrix sp. A1506, was synthesized through the precursor-directed in situ synthesis (PDSS) method. The structure of 1 was determined b...
Silkworm model of bacterial infection facilitates the identification of lysocin E, a potent, ultra-rapid bactericidal antibiotic [0.03%]
家蚕模型细菌感染促进lysocin E的鉴定：一种强有力的超快杀菌抗生素
Hiroshi Hamamoto
Hiroshi Hamamoto
The development of novel antimicrobial agents is required to solve the problem of antimicrobial resistance. We established a quantitative method for evaluating the therapeutic efficacy of antimicrobial agents in a silkworm bacterial infecti...
The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612 [0.03%]
一株深海芽孢杆菌BacillushaloduransKDM612的次级代谢产物经生物转化后生成新的瑟瑞紫酮糖苷类化合物
Ryota Okamura,Katsuki Kikuchi,Akito Taniguchi et al.
Ryota Okamura et al.
Seriniquinone was isolated as a melanoma-selective anti-cancer agent from a culture broth of the marine-derived bacterium Serinicoccus marinus CNJ927 in 2014. It targets the unique small protein, dermcidin, which affects the drug resistance...
Antidermatophyte activity and PK/PD of ME1111 in a guinea pig model of tinea corporis [0.03%]
ME1111治疗须毛癣菌感染的体内抑真菌活性及药代动力学/药效学研究
Naomi Takei-Masuda,Yu Nagira,Natsuki Kubota-Ishida et al.
Naomi Takei-Masuda et al.
Onychomycosis, a superficial fungal infection of the nails, is prevalent in many areas of the world. Topical agents for onychomycosis need to reach the subungual layer and nail bed to exert antifungal activity in the presence of keratin, th...
Correction: New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602 [0.03%]
订正：来源于Embleya菌株的新石松次番松素B和C与共产生的化合物L-156结合后可协同增强抗耐甲氧西林金黄色葡萄球菌活性
Hideki Hashizume,Shigeko Harada,Ryuichi Sawa et al.
Hideki Hashizume et al.
Published Erratum
The Journal of antibiotics. 2024 Jul;77(7):475. DOI:10.1038/s41429-024-00722-6 2024
Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21 [0.03%]
来源于致病有肋球柱霉的新环状二肽半胱胺酰亚麻酸A和B及其生物合成基因簇
Keisuke Kobayashi,Rio Tejima,Kenichiro Nagai et al.
Keisuke Kobayashi et al.
Two new cyclic dipeptides, paranazzamides A (1) and B (2) containing a C7-prenylated tryptophan, were isolated from a culture broth of snake fungal disease-isolate Paranannizziopsis sp. UH-21. This is the first report on the new secondary m...